Nucb2
Gene Detail

Symbol Name ID

Nucb2 nucleobindin 2 MGI:1858179

Synonyms

Calnuc, NEFA, nesfatin-1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

61.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:116504374-116540584 bp, + strand From Ensembl annotation of GRCm38   36211 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Nucb2 ± 2 cM)

Gene Tree: Nucb2

Human ortholog

NUCB2 nucleobindin 2 NCBI Gene ID 4925
Human Synonyms: NEFA
Human Chr11:17298286-17353070 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)
 

Homozygous mutation of this gene results in decreased heart rate and increased serum alkaline phosphatase levels.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cellular calcium ion homeostasis
Component	cytoplasm, endoplasmic reticulum, ...
Function	calcium ion binding, DNA binding, ...

External Resources: FuncBase

Expression

cDNA source data(67)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(67) cDNA(67)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030659 (Evidence)
Entrez Gene	53322 (Evidence)
UniGene	9901
DFCI	TC1578440
DoTS	DT.111017420, DT.491071
NIA Mouse Gene Index	U008668
Consensus CDS Project	CCDS40100.1, CCDS52372.1
International Mouse Knockout Project Status	Nucb2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030659	Ensembl Gene Model | MGI Sequence Detail	36211	C57BL/6J
transcript	ENSMUST00000032895	Ensembl | MGI Sequence Detail	1680	Not Applicable
polypeptide	ENSMUSP00000032895	Ensembl | MGI Sequence Detail	420	Not Applicable

All sequences(26) RefSeq(3) UniProt(3)

Polymorphisms

SNPs(151 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002048	Calcium-binding EF-hand
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR018249	EF-HAND 2
InterPro	IPR011992	EF-hand-like domain
Protein Ontology	PR:000011480	nucleobindin-2

References

(Earliest) J:63800 Taniguchi N, et al., The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm. J Biol Chem. 2000 Oct 13;275(41):31674-81
(Latest) J:192163 Gotoh K, et al., Nesfatin-1, corticotropin-releasing hormone, thyrotropin-releasing hormone, and neuronal histamine interact in the hypothalamus to regulate feeding behavior. J Neurochem. 2013 Jan;124(1):90-9
All references(35)

Other accession IDs

MGI:2142012