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Nucb2
Gene Detail
Symbol

Name
ID
Nucb2
nucleobindin 2
MGI:1858179
Synonyms
Calnuc, NEFA, nesfatin-1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
61.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:116504369-116540554 bp, + strand
From VEGA annotation of GRCm38

  36186 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3676  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Nucb2

Human
homologs
Human Homolog NUCB2, nucleobindin 2
NCBI Gene ID 4925
neXtProt AC  NX_P80303
Human Synonyms  HEL-S-109, NEFA
Human Chr (Location)  11p15.1; chr11:17260337-17349963 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in decreased heart rate and increased serum alkaline phosphatase levels.
 
Interactions
Nucb2 interacts with 45 markers (Mir24-1, Mir24-2, Mir99a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cellular calcium ion homeostasis
Component cell, cytoplasm, ...
Function calcium ion binding, DNA binding, ...
External Resources: FuncBase
Expression
cDNA source data(66)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(66) cDNA(66)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000043201 (Evidence)
Ensembl Gene ModelENSMUSG00000030659 (Evidence)
Entrez Gene53322 (Evidence)
UniGene9901
DFCITC1578440
DoTSDT.111017420, DT.491071
NIA Mouse Gene IndexU008668
Consensus CDS ProjectCCDS40100.1, CCDS52372.1
International Mouse Knockout Project StatusNucb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043201 VEGA Gene Model | MGI Sequence Detail 36186 C57BL/6J ±  kb
transcript OTTMUST00000113295 VEGA | MGI Sequence Detail 1655 Not Applicable 
polypeptide OTTMUSP00000063387 VEGA | MGI Sequence Detail 420 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(15) UniProt(7)
Polymorphisms
SNPs within 2kb(277 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
Protein Ontology PR:000011480 nucleobindin-2
References
(Earliest) J:63800 Taniguchi N, et al., The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm. J Biol Chem. 2000 Oct 13;275(41):31674-81
(Latest) J:192163 Gotoh K, et al., Nesfatin-1, corticotropin-releasing hormone, thyrotropin-releasing hormone, and neuronal histamine interact in the hypothalamus to regulate feeding behavior. J Neurochem. 2013 Jan;124(1):90-9
All references(36)
Other
accession IDs
MGI:2142012

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory