Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NRG3
  • Mouse genes Nrg3
  • Rat genes
  • Zfish genes nrg3b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nrg3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0045499	chemorepellent activity	Nrg3	IDA		Mouse	PMID:22376909
Molecular Function	GO:0005515	protein binding	Nrg3	IPI	UniProtKB:Q15303	Mouse	PMID:9275162
Molecular Function	GO:0048018	receptor ligand activity	NRG3	IDA		Human	PMID:12466964
Molecular Function	GO:0048018	receptor ligand activity	Nrg3	IPI	UniProtKB:Q15303	Mouse	PMID:9275162
Molecular Function	GO:0048018	receptor ligand activity	Nrg3	IPI	UniProtKB:Q15303	Mouse	PMID:12466964
Cellular Component	GO:0005615	extracellular space	NRG3	IDA		Human	PMID:12466964
Cellular Component	GO:0005615	extracellular space	Nrg3	IPI	UniProtKB:Q15303	Mouse	PMID:9275162
Cellular Component	GO:0005615	extracellular space	Nrg3	IDA		Mouse	PMID:30049711
Cellular Component	GO:0098978	glutamatergic synapse	NRG3	IDA		Human	PMID:29114105
Cellular Component	GO:0098978	glutamatergic synapse	NRG3	IMP		Human	PMID:29114105
Cellular Component	GO:0098978	glutamatergic synapse	Nrg3	IMP		Mouse	PMID:30049711
Cellular Component	GO:0098978	glutamatergic synapse	Nrg3	IDA		Mouse	PMID:30049711
Cellular Component	GO:0045202	synapse	Nrg3	IMP		Mouse	PMID:33320083
Cellular Component	GO:0045202	synapse	Nrg3	IDA		Mouse	PMID:33320083
Biological Process	GO:0021842	chemorepulsion involved in interneuron migration from the subpallium to the cortex	Nrg3	IMP		Mouse	PMID:22376909
Biological Process	GO:0038130	ERBB4 signaling pathway	NRG3	IDA		Human	PMID:12466964
Biological Process	GO:0038130	ERBB4 signaling pathway	Nrg3	IPI	UniProtKB:Q15303	Mouse	PMID:9275162
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	Nrg3	IPI	UniProtKB:Q15303	Mouse	PMID:9275162
Biological Process	GO:0038138	ERBB4-ERBB4 signaling pathway	Nrg3	IPI	UniProtKB:Q15303	Mouse	PMID:12466964
Biological Process	GO:0035556	intracellular signal transduction	Nrg3	IDA		Mouse	PMID:9275162
Biological Process	GO:0030879	mammary gland development	Nrg3	IDA		Mouse	PMID:16140987
Biological Process	GO:0030879	mammary gland development	Nrg3	IMP	MGI:MGI:1889610	Mouse	PMID:16140987
Biological Process	GO:0060596	mammary placode formation	Nrg3	IMP	MGI:MGI:1889610	Mouse	PMID:10723730
Biological Process	GO:0050804	modulation of chemical synaptic transmission	NRG3	IDA		Human	PMID:29114105
Biological Process	GO:0050804	modulation of chemical synaptic transmission	NRG3	IMP		Human	PMID:29114105
Biological Process	GO:2001223	negative regulation of neuron migration	Nrg3	IDA		Mouse	PMID:22376909
Biological Process	GO:0007389	pattern specification process	Nrg3	IMP	MGI:MGI:1889610	Mouse	PMID:10723730
Biological Process	GO:0007416	synapse assembly	Nrg3	IDA		Mouse	PMID:30049711
Biological Process	GO:0007416	synapse assembly	Nrg3	IMP		Mouse	PMID:30049711

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern