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Nrg3 Gene Detail
Summary
  • Symbol
    Nrg3
  • Name
    neuregulin 3
  • Synonyms
    ska
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097165
    NCBI Gene: 18183
  • Alliance
    genome feature page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:38090909-39195045 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 22.18 cM, cytoband B
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    34022 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097165
 protein coding gene Chr14:38086093-39195045 (-)
129S1/SvImJ ENSMUSG00200037093
 protein coding gene Chr14:29974034-31078375 (-)
A/J ENSMUSG00195011945
 protein coding gene Chr14:30998045-32102466 (-)
AKR/J ENSMUSG00220033855
 protein coding gene Chr14:30144804-31249051 (-)
BALB/cJ ENSMUSG00180026435
 protein coding gene Chr14:30082455-31186826 (-)
C3H/HeJ ENSMUSG00175036828
 protein coding gene Chr14:30153839-31263266 (-)
C57BL/6NJ ENSMUSG00215031250
 protein coding gene Chr14:30395335-31499686 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019136
 protein coding gene Chr14:30458104-31553367 (-)
CAST/EiJ ENSTCUG00005021709
 protein coding gene Chr14:30176450-31249037 (-)
CBA/J ENSMUSG00210039220
 protein coding gene Chr14:30400326-31514279 (-)
DBA/2J ENSMUSG00185014350
 protein coding gene Chr14:34640994-35747630 (-)
FVB/NJ ENSMUSG00205015616
 protein coding gene Chr14:30270828-31376754 (-)
JF1/MsJ ENSUMUG00000032655
 protein coding gene Chr14:41961363-43054313 (-)
LP/J ENSMUSG00230037406
 protein coding gene Chr14:41967136-43065432 (-)
NOD/ShiLtJ ENSMUSG00190018299
 protein coding gene Chr14:30449772-31562197 (-)
NZO/HlLtJ ENSMUSG00225041708
 protein coding gene Chr14:36270375-37368753 (-)
PWK/PhJ ENSLUMG00010022234
 protein coding gene Chr14:18512668-19589708 (-)
SPRET/EiJ ENSMSPG00010002598
 protein coding gene Chr14:32192885-33277202 (-)
WSB/EiJ ENSIUOG00005011262
 protein coding gene Chr14:30237251-31335118 (-)



Homology
more
  • Human Ortholog
    NRG3, neuregulin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NRG3, neuregulin 3
  • Synonyms
    HRG3, pro-NRG3
  • Links
    NCBI Gene ID: 10718
    UniProt: P56975

  • Chr Location
    10q23.1; chr10:81875194-82987179 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nrg3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in abnormal, genetic background specific, mammary gland development. Male mice homozygous for a knock-out allele show novelty-induced hyperactivity, decreased prepulse inhibition, and impaired cued conditioning behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    69
  • cDNA Data
    8
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041014 Ensembl Gene Model | MGI Sequence Detail 1104137 C57BL/6J ±  kb
    transcript ENSMUST00000166968 Ensembl | MGI Sequence Detail 4011 Not Applicable  
    polypeptide ENSMUSP00000136884 Ensembl | MGI Sequence Detail 713 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 2
      cDNA 9
      Primer pair 4
      Other 8
      Antibodies 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1354957
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 12
      Phenotypes 16
    • Earliest
      J:42826 Zhang D, et al., Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9562-7
    • Latest
      J:357284 Lo Giudice Q, et al., Developmental emergence of first- and higher-order thalamic neuron molecular identities. Development. 2024 Sep 15;151(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory