About   Help   FAQ
Nrg3 Gene Detail
Summary
  • Symbol
    Nrg3
  • Name
    neuregulin 3
  • Synonyms
    ska
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097165
    NCBI Gene: 18183
  • Gene Overview
    MyGene.info: NRG3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:38368952-39473088 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 22.18 cM, cytoband B
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5224 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097165
protein coding gene Chr14:38365102-39473088 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021190
protein coding gene Chr14:31903339-33070188 (-)
A/J MGP_AJ_G0021138
protein coding gene Chr14:30608850-31718942 (-)
AKR/J MGP_AKRJ_G0021115
protein coding gene Chr14:31948478-33086278 (-)
BALB/cJ MGP_BALBcJ_G0021142
protein coding gene Chr14:30835531-31965474 (-)
C3H/HeJ MGP_C3HHeJ_G0020925
protein coding gene Chr14:31861442-33021240 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021574
protein coding gene Chr14:33077655-34289805 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019136
protein coding gene Chr14:30458104-31553367 (-)
CAST/EiJ MGP_CASTEiJ_G0020450
protein coding gene Chr14:31715318-32853926 (-)
CBA/J MGP_CBAJ_G0020891
protein coding gene Chr14:34301815-35573286 (-)
DBA/2J MGP_DBA2J_G0021014
protein coding gene Chr14:30618956-31737314 (-)
FVB/NJ MGP_FVBNJ_G0020998
protein coding gene Chr14:30594737-31686593 (-)
LP/J MGP_LPJ_G0021083
protein coding gene Chr14:32161881-33292298 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021024
protein coding gene Chr14:33625461-35011720 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021607
protein coding gene Chr14:31782131-32941645 (-)
PWK/PhJ MGP_PWKPhJ_G0020198
protein coding gene Chr14:30148964-31259831 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020022
protein coding gene Chr14:31381619-32543216 (-)
WSB/EiJ MGP_WSBEiJ_G0020505
protein coding gene Chr14:31852316-33016330 (-)



Homology
more
  • Human Ortholog
    NRG3, neuregulin 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NRG3, neuregulin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HRG3, pro-NRG3
  • Links
    NCBI Gene ID: 10718
    neXtProt AC: NX_P56975
    UniProt: P56975

  • Chr Location
    10q23.1; chr10:81875298-82989979 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    2 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene result in abnormal, genetic background specific, mammary gland development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041014 Ensembl Gene Model | MGI Sequence Detail 1104137 C57BL/6J ±  kb
    transcript ENSMUST00000166968 Ensembl | MGI Sequence Detail 4011 Not Applicable  
    polypeptide ENSMUSP00000136884 Ensembl | MGI Sequence Detail 713 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 2
      cDNA 7
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1354957
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 14
      Gene Ontology 8
      Phenotypes 6
    • Earliest
      J:42826 Zhang D, et al., Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9562-7
    • Latest
      J:263064 Elliott KH, et al., A novel role for cilia-dependent sonic hedgehog signaling during submandibular gland development. Dev Dyn. 2018 Jun;247(6):818-831

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory