Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NPHS1
  • Mouse genes Nphs1
  • Rat genes Nphs1
  • Zfish genes nphs1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nphs1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0051393	alpha-actinin binding	Nphs1	IPI	RGD:61816	Rat	PMID:15331416|RGD:1600864
Molecular Function	GO:0017022	myosin binding	NPHS1	IPI	UniProtKB:O00159	Human	PMID:21402783
Molecular Function	GO:0005515	protein binding	NPHS1	IPI	UniProtKB:P16333	Human	PMID:16525419
Molecular Function	GO:0005515	protein binding	NPHS1	IPI	UniProtKB:B1Q236	Human	PMID:21858180
Molecular Function	GO:0005515	protein binding	NPHS1	IPI	UniProtKB:P46940	Human	PMID:22662192
Molecular Function	GO:0005515	protein binding	Nphs1	IPI	PR:Q7TSU7	Mouse	PMID:21306299
Molecular Function	GO:0005515	protein binding	Nphs1	IPI	PR:Q91X05	Mouse	PMID:11733557
Molecular Function	GO:0005515	protein binding	Nphs1	IPI	PR:Q8BR86	Mouse	PMID:18752272
Molecular Function	GO:0005515	protein binding	Nphs1	IPI	PR:Q61143	Mouse	PMID:15924139
Molecular Function	GO:0005515	protein binding	Nphs1	IPI	UniProtKB:B5DFH1	Rat	PMID:15994232|RGD:8553727
Molecular Function	GO:0005515	protein binding	Nphs1	IPI	UniProtKB:O88382	Rat	PMID:15994232|RGD:8553727
Molecular Function	GO:0005515	protein binding	Nphs1	IPI	UniProtKB:P16086	Rat	PMID:15994232|RGD:8553727
Molecular Function	GO:0005515	protein binding	Nphs1	IPI	UniProtKB:Q62915	Rat	PMID:15994232|RGD:8553727
Molecular Function	GO:0005515	protein binding	Nphs1	IPI	UniProtKB:Q9WUX0	Rat	PMID:15994232|RGD:8553727
Molecular Function	GO:0005515	protein binding	Nphs1	IPI	UniProtKB:O88382	Rat	PMID:20534871|RGD:8553386
Molecular Function	GO:0005515	protein binding	Nphs1	IPI	UniProtKB:Q91ZD4	Rat	PMID:20534871|RGD:8553386
Molecular Function	GO:0005515	protein binding	Nphs1	IPI	UniProtKB:P97710	Rat	PMID:22747997|RGD:8553639
Molecular Function	GO:0005515	protein binding	nphs1	IPI	ZFIN:ZDB-GENE-051102-2	Zfish	PMID:24337247
Molecular Function	GO:0019904	protein domain specific binding	Nphs1	IPI	RGD:1311884	Rat	PMID:15331416|RGD:1600864
Molecular Function	GO:0019904	protein domain specific binding	Nphs1	IPI	RGD:62004	Rat	PMID:15331416|RGD:1600864
Molecular Function	GO:0019904	protein domain specific binding	Nphs1	IPI	RGD:621855	Rat	PMID:15331416|RGD:1600864
Molecular Function	GO:0030507	spectrin binding	Nphs1	IPI	RGD:621714	Rat	PMID:15331416|RGD:1600864
Molecular Function	GO:0030507	spectrin binding	Nphs1	IPI	RGD:727922	Rat	PMID:15331416|RGD:1600864
Cellular Component	GO:0005604	basement membrane	Nphs1	IDA		Rat	PMID:21876538|RGD:38599163
Cellular Component	GO:0042995	cell projection	Nphs1	IDA		Mouse	MGI:MGI:4887519|PMID:20534871
Cellular Component	GO:0005737	cytoplasm	Nphs1	IDA		Rat	PMID:21876538|RGD:38599163
Cellular Component	GO:0070062	extracellular exosome	NPHS1	HDA		Human	PMID:19056867
Cellular Component	GO:0005925	focal adhesion	Nphs1	IDA		Mouse	PMID:29162887
Cellular Component	GO:0016020	membrane	Nphs1	IDA		Rat	PMID:11880318|RGD:633458
Cellular Component	GO:0045121	membrane raft	Nphs1	IDA		Rat	PMID:11880318|RGD:633458
Cellular Component	GO:0005886	plasma membrane	NPHS1	IDA		Human	PMID:17464107
Cellular Component	GO:0005886	plasma membrane	Nphs1	IDA		Mouse	PMID:15924139
Cellular Component	GO:0005886	plasma membrane	Nphs1	IDA		Rat	PMID:20534871|RGD:8553386
Cellular Component	GO:0032991	protein-containing complex	Nphs1	IDA		Rat	PMID:15331416|RGD:1600864
Cellular Component	GO:0036057	slit diaphragm	Nphs1	IDA		Rat	PMID:15994232|RGD:8553727
Biological Process	GO:0007155	cell adhesion	Nphs1	IGI	MGI:MGI:2442334	Mouse	PMID:21306299
Biological Process	GO:0007155	cell adhesion	Nphs1	IGI	MGI:MGI:1891396	Mouse	PMID:21306299
Biological Process	GO:0021782	glial cell development	nphs1	IMP	ZFIN:ZDB-CRISPR-191009-85,ZFIN:ZDB-CRISPR-191009-86	Zfish	PMID:30924555
Biological Process	GO:0032836	glomerular basement membrane development	NPHS1	IEP		Human	PMID:17464107
Biological Process	GO:0003094	glomerular filtration	nphs1	IMP	ZFIN:ZDB-MRPHLNO-051102-1	Zfish	PMID:25962121
Biological Process	GO:0003094	glomerular filtration	nphs1	IMP	ZFIN:ZDB-MRPHLNO-051102-1	Zfish	PMID:21949092
Biological Process	GO:0007254	JNK cascade	Nphs1	IDA		Mouse	PMID:11562357
Biological Process	GO:0001822	kidney development	nphs1	IMP	ZFIN:ZDB-MRPHLNO-051102-1	Zfish	PMID:16102746
Biological Process	GO:0000165	MAPK cascade	Nphs1	IDA		Mouse	PMID:11562357
Biological Process	GO:0007520	myoblast fusion	Nphs1	IMP		Mouse	MGI:MGI:3849657|PMID:19470472
Biological Process	GO:0072015	podocyte development	NPHS1	IEP		Human	PMID:17464107
Biological Process	GO:0030838	positive regulation of actin filament polymerization	Nphs1	IGI	MGI:MGI:1891396	Mouse	PMID:17923684
Biological Process	GO:0030838	positive regulation of actin filament polymerization	Nphs1	IGI	MGI:MGI:109601	Mouse	PMID:17923684
Biological Process	GO:0030838	positive regulation of actin filament polymerization	Nphs1	IGI	MGI:MGI:95805	Mouse	PMID:17923684
Biological Process	GO:0039021	pronephric glomerulus development	nphs1	IMP	ZFIN:ZDB-MRPHLNO-140522-5	Zfish	PMID:24337247
Biological Process	GO:0039021	pronephric glomerulus development	nphs1	IGI	RefSeq:NM_004646.3,ZFIN:ZDB-MRPHLNO-140522-5	Zfish	PMID:24337247
Biological Process	GO:0039021	pronephric glomerulus development	nphs1	IMP	ZFIN:ZDB-MRPHLNO-200130-1	Zfish	PMID:31152064
Biological Process	GO:0035418	protein localization to synapse	NPHS1	IGI	UniProtKB:Q9U3P2	Human	PMID:21858180
Biological Process	GO:0060041	retina development in camera-type eye	nphs1	IMP	ZFIN:ZDB-CRISPR-191009-85,ZFIN:ZDB-CRISPR-191009-86	Zfish	PMID:30924555
Biological Process	GO:0048741	skeletal muscle fiber development	nphs1	IMP	ZFIN:ZDB-MRPHLNO-051102-1	Zfish	PMID:19470472
Biological Process	GO:0007519	skeletal muscle tissue development	Nphs1	IMP		Mouse	MGI:MGI:3849657|PMID:19470472
Biological Process	GO:0036060	slit diaphragm assembly	Nphs1	IMP		Mouse	MGI:MGI:1929558|PMID:11136707

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern