Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MYLK2
  • Mouse genes Mylk2
  • Rat genes Mylk2
  • Zfish genes mylk2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mylk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0032027	myosin light chain binding	Mylk2	IMP		Rat	PMID:16002744|RGD:1600503
Molecular Function	GO:0004687	myosin light chain kinase activity	MYLK2	IDA		Human	PMID:16448786
Molecular Function	GO:0004687	myosin light chain kinase activity	Mylk2	IMP		Rat	PMID:16002744|RGD:1600503
Molecular Function	GO:0004687	myosin light chain kinase activity	Mylk2	IDA		Rat	PMID:2839493|RGD:729267
Molecular Function	GO:0005515	protein binding	MYLK2	IPI	UniProtKB:Q06413	Human	PMID:21556048
Molecular Function	GO:0005515	protein binding	MYLK2	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	MYLK2	IPI	UniProtKB:Q9BYV2	Human	PMID:31391242
Molecular Function	GO:0005515	protein binding	MYLK2	IPI	UniProtKB:P08238	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MYLK2	IPI	UniProtKB:O76024	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Mylk2	IPI	UniProtKB:Q06413	Mouse	MGI:MGI:5013486|PMID:21556048
Molecular Function	GO:0005515	protein binding	Mylk2	IPI	UniProtKB:Q8CFN5	Mouse	MGI:MGI:3829850|PMID:18955699
Cellular Component	GO:0005737	cytoplasm	MYLK2	IDA		Human	PMID:21556048
Cellular Component	GO:0030425	dendrite	Mylk2	IDA		Rat	PMID:16515842|RGD:1600505
Cellular Component	GO:0043197	dendritic spine	Mylk2	IDA		Rat	PMID:16515842|RGD:1600505
Cellular Component	GO:0043025	neuronal cell body	Mylk2	IDA		Rat	PMID:16515842|RGD:1600505
Cellular Component	GO:0005634	nucleus	MYLK2	IDA		Human	PMID:21556048
Cellular Component	GO:0014069	postsynaptic density	Mylk2	IDA		Rat	PMID:16515842|RGD:1600505
Cellular Component	GO:0045202	synapse	Mylk2	IGI	MGI:MGI:88323	Mouse	MGI:MGI:3625625|PMID:16606832
Cellular Component	GO:0008021	synaptic vesicle	Mylk2	IDA		Rat	PMID:16515842|RGD:1600505
Cellular Component	GO:0043195	terminal bouton	Mylk2	IDA		Rat	PMID:16515842|RGD:1600505
Biological Process	GO:0055008	cardiac muscle tissue morphogenesis	MYLK2	IMP		Human	PMID:16448786
Biological Process	GO:0006936	muscle contraction	Mylk2	IEP		Rat	PMID:2839493|RGD:729267
Biological Process	GO:0007274	neuromuscular synaptic transmission	Mylk2	IGI	MGI:MGI:88323	Mouse	PMID:16606832
Biological Process	GO:0007274	neuromuscular synaptic transmission	Mylk2	IMP		Mouse	PMID:16606832
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	MYLK2	IDA		Human	PMID:21556048
Biological Process	GO:0031448	positive regulation of fast-twitch skeletal muscle fiber contraction	Mylk2	IMP		Rat	PMID:12748068|RGD:1580242
Biological Process	GO:0010628	positive regulation of gene expression	MYLK2	IDA		Human	PMID:21556048
Biological Process	GO:0046777	protein autophosphorylation	MYLK2	IDA		Human	PMID:21556048
Biological Process	GO:0006468	protein phosphorylation	Mylk2	IMP		Rat	PMID:16002744|RGD:1600503
Biological Process	GO:0006468	protein phosphorylation	Mylk2	IDA		Rat	PMID:16279942|RGD:1600507
Biological Process	GO:0051726	regulation of cell cycle	Mylk2	IMP		Rat	PMID:16799973|RGD:1600509
Biological Process	GO:0043408	regulation of MAPK cascade	Mylk2	IMP		Rat	PMID:15962288|RGD:1600506
Biological Process	GO:0006937	regulation of muscle contraction	Mylk2	IMP		Rat	PMID:16002744|RGD:1600503
Biological Process	GO:0032971	regulation of muscle filament sliding	MYLK2	IDA		Human	PMID:16448786
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity	Mylk2	IMP		Rat	PMID:16515842|RGD:1600505
Biological Process	GO:0035914	skeletal muscle cell differentiation	MYLK2	IDA		Human	PMID:21556048
Biological Process	GO:0014816	skeletal muscle satellite cell differentiation	Mylk2	IMP		Mouse	MGI:MGI:5013486|PMID:21556048
Biological Process	GO:0006941	striated muscle contraction	MYLK2	IDA		Human	PMID:16448786
Biological Process	GO:0048489	synaptic vesicle transport	Mylk2	IMP		Rat	PMID:15980175|RGD:1600508
Biological Process	GO:0006833	water transport	Mylk2	IMP		Rat	PMID:15347643|RGD:1580245

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern