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Mylk2
Gene Detail
Symbol

Name
ID
Mylk2
myosin, light polypeptide kinase 2, skeletal muscle
MGI:2139434
Synonyms
9830004H17Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
75.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:152911352-152923068 bp, + strand
From VEGA annotation of GRCm38

  11717 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Mylk2

Human
homologs
Human Homolog MYLK2, myosin light chain kinase 2
NCBI Gene ID 85366
neXtProt AC  NX_Q9H1R3
Human Synonyms  KMLC, MLCK, MLCK2, skMLCK
Human Chr (Location)  20q13.31; chr20:31819312-31834697 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MYLK2
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Homozygous knockout mice display impaired skeletal muscle twitch tension response to tetanic stimulation.
 
Interactions
Mylk2 interacts with 169 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process cardiac muscle cell differentiation, cardiac muscle tissue morphogenesis, ...
Component cytoplasm, dendrite, ...
Function ATP binding, calmodulin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
cDNA source data(5)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000015847 (Evidence)
Ensembl Gene ModelENSMUSG00000027470 (Evidence)
Entrez Gene228785 (Evidence)
UniGene250604
DFCITC1614648, TC1620920
DoTSDT.40143617
NIA Mouse Gene IndexU002657
EC2.7.11.18
Consensus CDS ProjectCCDS38282.2
International Mouse Knockout Project StatusMylk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015847 VEGA Gene Model | MGI Sequence Detail 11717 C57BL/6J ±  kb
transcript OTTMUST00000037666 VEGA | MGI Sequence Detail 2951 Not Applicable 
polypeptide OTTMUSP00000016889 VEGA | MGI Sequence Detail 613 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020636 Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010846 myosin light chain kinase 2, skeletal/cardiac muscle
References
(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173154 Al Madhoun AS, et al., Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C. EMBO J. 2011;30(12):2477-89
All references(30)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory