Mylk2
Gene Detail

Symbol Name ID

Mylk2 myosin, light polypeptide kinase 2, skeletal muscle MGI:2139434

Synonyms

9830004H17Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

75.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:152911352-152923068 bp, + strand From VEGA annotation of GRCm38   11717 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:13223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Mylk2

Human homologs

Human Homolog		MYLK2, myosin light chain kinase 2
NCBI Gene ID		85366
neXtProt AC		NX_Q9H1R3
Human Synonyms		KMLC, MLCK, MLCK2, skMLCK
Human Chr (Location)		20q13.31; chr20:30407178-30422500 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MYLK2

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous knockout mice display impaired skeletal muscle twitch tension response to tetanic stimulation.

 

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	cardiac muscle tissue morphogenesis, neuromuscular synaptic transmission, ...
Component	cytoplasm, dendrite, ...
Function	ATP binding, calmodulin binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

cDNA source data(5)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(5) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000015847 (Evidence)
Ensembl Gene Model	ENSMUSG00000027470 (Evidence)
Entrez Gene	228785 (Evidence)
UniGene	250604
DFCI	TC1614648, TC1620920
DoTS	DT.40143617
NIA Mouse Gene Index	U002657
EC	2.7.11.18
Consensus CDS Project	CCDS38282.2
International Mouse Knockout Project Status	Mylk2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015847	VEGA Gene Model | MGI Sequence Detail	11717	C57BL/6J
transcript	OTTMUST00000037666	VEGA | MGI Sequence Detail	2951	Not Applicable
polypeptide	OTTMUSP00000016889	VEGA | MGI Sequence Detail	613	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(76 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020636	Calcium/calmodulin-dependent/calcium-dependent protein kinase
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000010846	myosin light chain kinase 2, skeletal/cardiac muscle

References

(Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:173154 Al Madhoun AS, et al., Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C. EMBO J. 2011;30(12):2477-89
All references(30)