Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MYLK
  • Mouse genes Mylk
  • Rat genes Mylk
  • Zfish genes mylka,mylkb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mylk

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019899	enzyme binding	Mylk	IPI	UniProtKB:Q09LZ8|UniProtKB:Q09M05|UniProtKB:Q641K1	Mouse	MGI:MGI:4849873|PMID:21074048
Molecular Function	GO:0004687	myosin light chain kinase activity	MYLK	IDA		Human	PMID:16284075
Molecular Function	GO:0005515	protein binding	MYLK	IPI	UniProtKB:P16333	Human	PMID:17474147
Molecular Function	GO:0005515	protein binding	MYLK	IPI	UniProtKB:Q9HD26	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Mylk	IPI	UniProtKB:Q9JMG9	Mouse	MGI:MGI:3688344|PMID:15102471
Cellular Component	GO:0015629	actin cytoskeleton	MYLK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005911	cell-cell junction	Mylk	IDA		Mouse	PMID:23793062
Cellular Component	GO:0032154	cleavage furrow	MYLK	IDA		Human	PMID:15020676
Cellular Component	GO:0005737	cytoplasm	MYLK	IDA		Human	PMID:20053363
Cellular Component	GO:0030027	lamellipodium	MYLK	IDA		Human	PMID:20053363
Cellular Component	GO:0005886	plasma membrane	MYLK	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001725	stress fiber	MYLK	IDA		Human	PMID:15020676
Biological Process	GO:0060414	aorta smooth muscle tissue morphogenesis	MYLK	IMP		Human	PMID:21055718
Biological Process	GO:0032060	bleb assembly	MYLK	IMP		Human	PMID:20181817
Biological Process	GO:0007596	blood coagulation	mylka	IMP	ZFIN:ZDB-MRPHLNO-100520-7	Zfish	PMID:20002541
Biological Process	GO:0007596	blood coagulation	mylka	IMP	ZFIN:ZDB-MRPHLNO-100520-8	Zfish	PMID:20002541
Biological Process	GO:0071476	cellular hypotonic response	MYLK	IDA		Human	PMID:11976941
Biological Process	GO:0071277	cellular response to calcium ion	Mylk	IDA		Mouse	PMID:18524939
Biological Process	GO:0035865	cellular response to potassium ion	Mylk	IDA		Mouse	PMID:18524939
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Mylk	IDA		Mouse	PMID:18524939
Biological Process	GO:0051928	positive regulation of calcium ion transport	MYLK	IDA		Human	PMID:16284075
Biological Process	GO:0030335	positive regulation of cell migration	MYLK	IDA		Human	PMID:19826488
Biological Process	GO:0090303	positive regulation of wound healing	MYLK	IDA		Human	PMID:15825080
Biological Process	GO:2000145	regulation of cell motility	mylka	IGI	ZFIN:ZDB-MRPHLNO-050413-1,ZFIN:ZDB-MRPHLNO-120823-1,ZFIN:ZDB-MRPHLNO-120823-2,ZFIN:ZDB-MRPHLNO-120823-3,ZFIN:ZDB-MRPHLNO-120823-4,ZFIN:ZDB-MRPHLNO-120823-5	Zfish	PMID:22705393
Biological Process	GO:0006939	smooth muscle contraction	Mylk	IMP		Mouse	MGI:MGI:3820013|PMID:18586037
Biological Process	GO:0014820	tonic smooth muscle contraction	Mylk	IMP		Mouse	MGI:MGI:4452414|PMID:20018858

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern