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Gene Detail
myosin, light polypeptide kinase
Synonyms 9530072E15Rik, A930019C19Rik, Mlck, MLCK108, MLCK210, telokin
Feature Type protein coding gene
Genetic Map
Chromosome 16
24.49 cM
Detailed Genetic Map ± 1 cM

Mapping data(2)
Sequence Map
Chr16:34745210-35002420 bp, + strand
From VEGA annotation of GRCm38

  257211 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:14202  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: myosin light chain kinase, smooth muscle and non-muscle
Gene Tree: Mylk

Human Homolog MYLK, myosin light chain kinase
NCBI Gene ID 4638
neXtProt AC  NX_Q15746
Human Synonyms  AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK
Human Chr (Location)  3q21; chr3:123612296-123884302 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MYLK
alleles, and
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
Mice that lack the isoform abundant in endothelial cells show a reduced susceptibility to acute lung injury. Mice lacking the smooth muscle isoform exhibit partial pre- or neonatal lethality, short small intestine and impaired smooth muscle contraction in the colon.
Mylk interacts with 301 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
All GO classifications: (37 annotations)
Process actin filament organization, aorta smooth muscle tissue morphogenesis, ...
Component cell-cell junction, cell projection, ...
Function actin binding, ATP binding, ...
External Resources: FuncBase
Literature Summary: (10 records)
Data Summary: Results (62)    Tissues (37)    Images (17)
Theiler Stages: 12, 19, 20, 23, 27, 28
Assay TypeResults
RNA in situ 44
Western blot 18
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(19) cDNA(19)
Microarray probesets(7)
Other database
VEGA Gene ModelOTTMUSG00000017049 (Evidence)
Ensembl Gene ModelENSMUSG00000022836 (Evidence)
Entrez Gene107589 (Evidence)
DoTSDT.101133316, DT.110739001, DT.531159, DT.55111756, DT.94142348, DT.94267394, DT.94287968, DT.97363099
NIA Mouse Gene IndexU017053
Consensus CDS ProjectCCDS37320.1
International Mouse Knockout Project StatusMylk
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017049 VEGA Gene Model | MGI Sequence Detail 257211 C57BL/6J ±  kb
transcript OTTMUST00000041291 VEGA | MGI Sequence Detail 7824 Not Applicable 
polypeptide OTTMUSP00000018530 VEGA | MGI Sequence Detail 1950 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(1799 from dbSNP Build 137)
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR020675 Myosin light chain kinase-related
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010845 myosin light chain kinase, smooth muscle
References (Earliest) J:30019 Gallagher PJ, et al., Expression of a novel myosin light chain kinase in embryonic tissues and cultured cells. J Biol Chem. 1995 Dec 8;270(49):29090-5
(Latest) J:205441 Liang Y, et al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66
All references(67)
accession IDs
MGI:1915492, MGI:2142787, MGI:2443108

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory