Mylk
Gene Detail

Symbol Name ID

Mylk myosin, light polypeptide kinase MGI:894806

Synonyms

9530072E15Rik, A930019C19Rik, Mlck, MLCK108, MLCK210, telokin

Feature Type

protein coding gene

Genetic Map

Chromosome 16

24.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:34745210-35002420 bp, + strand From VEGA annotation of GRCm38   257211 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:14202  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: myosin light chain kinase, smooth muscle and non-muscle
Gene Tree: Mylk

Human homologs

Human Homolog		MYLK, myosin light chain kinase
NCBI Gene ID		4638
neXtProt AC		NX_Q15746
Human Synonyms		AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK
Human Chr (Location)		3q21; chr3:123331143-123603149 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MYLK

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice that lack the isoform abundant in endothelial cells and retain the isoform that is predominant in smooth muscle show a reduced susceptibility to acute lung injury.

 

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	aorta smooth muscle tissue morphogenesis, bleb assembly, ...
Component	cell projection, cleavage furrow, ...
Function	actin binding, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (62)    Tissues (35)    Images (17)
Theiler Stages: 12, 19, 20, 23, 28

Assay Type	Results
RNA in situ	44
Western blot	18

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) cDNA(19)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000017049 (Evidence)
Ensembl Gene Model	ENSMUSG00000022836 (Evidence)
Entrez Gene	107589 (Evidence)
DoTS	DT.101133316, DT.110739001, DT.531159, DT.55111756, DT.94142348, DT.94267394, DT.94287968, DT.97363099
NIA Mouse Gene Index	U017053
EC	2.7.11.18
Consensus CDS Project	CCDS37320.1
International Mouse Knockout Project Status	Mylk

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017049	VEGA Gene Model | MGI Sequence Detail	257211	C57BL/6J
transcript	OTTMUST00000041291	VEGA | MGI Sequence Detail	7824	Not Applicable
polypeptide	OTTMUSP00000018530	VEGA | MGI Sequence Detail	1950	Not Applicable

All sequences(50) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(1321 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR020675	Myosin light chain kinase-related
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000010845	myosin light chain kinase, smooth muscle

References

(Earliest) J:30019 Gallagher PJ, et al., Expression of a novel myosin light chain kinase in embryonic tissues and cultured cells. J Biol Chem. 1995 Dec 8;270(49):29090-5
(Latest) J:195102 Yu Y, et al., Deletion of myosin light chain kinase in endothelial cells has a minor effect on the lipopolysaccharide-induced increase in microvascular endothelium permeability in mice. FEBS J. 2012 Apr;279(8):1485-94
All references(60)

Other accession IDs

MGI:1915492, MGI:2142787, MGI:2443108