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Mylk Gene Detail
Summary
  • Symbol
    Mylk
  • Name
    myosin, light polypeptide kinase
  • Synonyms
    9530072E15Rik, A930019C19Rik, Mlck, MLCK108, MLCK210, nmMlck, telokin
  • Feature Type
    protein coding gene
  • IDs
    MGI:894806
    NCBI Gene: 107589
  • Gene Overview
    MyGene.info: MYLK
Location & Maps
more
  • Sequence Map
    Chr16:34745210-35002420 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      257211 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 24.49 cM
  • Mapping Data
    2 experiments
Homology
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  • Human Ortholog
    MYLK, myosin light chain kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MYLK, myosin light chain kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MSTP083, MYLK1, smMLCK
  • Links
    NCBI Gene ID: 4638
    neXtProt AC: NX_Q15746

  • Chr Location
    3q21; chr3:123612296-123884302 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MYLK associations

Human Disease Mouse Models
       Aortic Aneurysm, Familial Thoracic 7; AAT7   OMIM: 613780
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 5 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice that lack the isoform abundant in endothelial cells show a reduced susceptibility to acute lung injury. Mice lacking the smooth muscle isoform exhibit partial pre- or neonatal lethality, short small intestine and impaired smooth muscle contraction in the colon.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017049 VEGA Gene Model | MGI Sequence Detail 257211 C57BL/6J ±  kb
transcript OTTMUST00000041291 VEGA | MGI Sequence Detail 7824 Not Applicable  
polypeptide OTTMUSP00000018530 VEGA | MGI Sequence Detail 1950 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1797 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 19
    cDNA 19

    Microarray probesets 7
Other
Accession IDs
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MGI:1915492, MGI:2142787, MGI:2443108
References
more
  • Summaries
    All 75
    Developmental Gene Expression 14
    Gene Ontology 10
    Phenotypes 30
  • Earliest
    J:30019 Gallagher PJ, et al., Expression of a novel myosin light chain kinase in embryonic tissues and cultured cells. J Biol Chem. 1995 Dec 8;270(49):29090-5
  • Latest
    J:226425 Konstantinidis DG, et al., Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation. Blood. 2015 Sep 17;126(12):1473-82

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory