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Gene Ontology Browser
Term Detail
GO term:cleavage furrow
GO id:GO:0032154
Definition:In animal cells, the first sign of cleavage, or cytokinesis, is the appearance of a shallow groove in the cell surface near the old metaphase plate. A contractile ring containing actin and myosin is located just inside the plasma membrane at the location of the furrow. Ring contraction is associated with centripetal growth of the membrane that deepens the cleavage furrow and divides the cytoplasm of the two daughter cells. While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists.
Number of paths to term: 4

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-acell division site
                                        part-ofcell division site part
                                                is-aactomyosin contractile ring +
                                                is-acellular bud neck septin structure +
                                                is-acleavage apparatus septin structure +
                                                is-acleavage furrow [GO:0032154] (26 genes, 27 annotations)
                                                is-aequatorial microtubule organizing center +
                                                is-agamma-tubulin large complex, equatorial microtubule organizing center
                                                is-aGin4 complex
                                                is-amedial cortex +
                                                is-amedial cortical node
                                                is-amedial membrane band


Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-acell division site part
                                        is-aactomyosin contractile ring +
                                        is-acellular bud neck septin structure +
                                        is-acleavage apparatus septin structure +
                                        is-acleavage furrow [GO:0032154] (26 genes, 27 annotations)
                                        is-aequatorial microtubule organizing center +
                                        is-agamma-tubulin large complex, equatorial microtubule organizing center
                                        is-aGin4 complex
                                        is-amedial cortex +
                                        is-amedial cortical node
                                        is-amedial membrane band


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-acell division site
                                part-ofcell division site part
                                        is-aactomyosin contractile ring +
                                        is-acellular bud neck septin structure +
                                        is-acleavage apparatus septin structure +
                                        is-acleavage furrow [GO:0032154] (26 genes, 27 annotations)
                                        is-aequatorial microtubule organizing center +
                                        is-agamma-tubulin large complex, equatorial microtubule organizing center
                                        is-aGin4 complex
                                        is-amedial cortex +
                                        is-amedial cortical node
                                        is-amedial membrane band


Gene_Ontology
        is-acellular_component
                is-acell part
                        is-acell division site part
                                is-aactomyosin contractile ring +
                                is-acellular bud neck septin structure +
                                is-acleavage apparatus septin structure +
                                is-acleavage furrow [GO:0032154] (26 genes, 27 annotations)
                                is-aequatorial microtubule organizing center +
                                is-agamma-tubulin large complex, equatorial microtubule organizing center
                                is-aGin4 complex
                                is-amedial cortex +
                                is-amedial cortical node
                                is-amedial membrane band


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory