Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Myh6

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MYH6
- Mouse genes Myh6
- Rat genes Myh6
- Zfish genes myh6,myh7,smyhc1,smyhc2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Myh6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Myh6	IDA		Rat	PMID:10651160\|RGD:1581167
Molecular Function	GO:0005524	ATP binding	Myh6	IMP		Rat	PMID:15471982\|RGD:1581170
Molecular Function	GO:0030899	calcium-dependent ATPase activity	Myh6	IMP		Rat	PMID:10651160\|RGD:1581167
Molecular Function	GO:0042802	identical protein binding	Myh6	IPI	UniProtKB:P02563	Rat	PMID:22728135\|RGD:8553265
Molecular Function	GO:0042802	identical protein binding	Myh6	IPI	RGD:62029	Rat	PMID:3693405\|RGD:1581165
Molecular Function	GO:0000146	microfilament motor activity	MYH6	IDA		Human	PMID:15621050
Molecular Function	GO:0000146	microfilament motor activity	MYH6	IMP		Human	PMID:16088376
Molecular Function	GO:0000146	microfilament motor activity	Myh6	IMP	MGI:MGI:3690299	Mouse	PMID:16983074
Molecular Function	GO:0000146	microfilament motor activity	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:15001446
Molecular Function	GO:0000146	microfilament motor activity	Myh6	IMP	MGI:MGI:3664197	Mouse	PMID:15001446
Molecular Function	GO:0000146	microfilament motor activity	Myh6	IMP		Rat	PMID:15020307\|RGD:1581168
Molecular Function	GO:0005515	protein binding	Myh6	IPI	UniProtKB:O70468	Mouse	MGI:MGI:5466448\|PMID:22982234
Molecular Function	GO:0005515	protein binding	Myh6	IPI	PR:O70468	Mouse	PMID:17075052
Molecular Function	GO:0019901	protein kinase binding	MYH6	IPI	UniProtKB:Q8IWU2	Human	PMID:18029400
Molecular Function	GO:0019901	protein kinase binding	MYH6	IPI	UniProtKB:Q8IWU2	Human	PMID:18429820
Molecular Function	GO:0044877	protein-containing complex binding	Myh6	IDA		Rat	PMID:3693405\|RGD:1581165
Cellular Component	GO:0005737	cytoplasm	Myh6	IDA		Rat	PMID:9359883\|RGD:1581166
Cellular Component	GO:0005739	mitochondrion	Myh6	IDA		Rat	PMID:20533907\|RGD:7327223
Cellular Component	GO:0005859	muscle myosin complex	Myh6	IDA		Rat	PMID:3693405\|RGD:1581165
Cellular Component	GO:0030016	myofibril	Myh6	IDA		Mouse	PMID:9884344
Cellular Component	GO:0030016	myofibril	Myh6	IDA		Mouse	PMID:8878443
Cellular Component	GO:0030016	myofibril	Myh6	IDA		Rat	PMID:10651160\|RGD:1581167
Cellular Component	GO:0016459	myosin complex	Myh6	IDA		Mouse	PMID:9884344
Cellular Component	GO:0016459	myosin complex	Myh6	IDA		Mouse	PMID:8482409
Cellular Component	GO:0016459	myosin complex	Myh6	IDA		Mouse	PMID:15001446
Cellular Component	GO:0001725	stress fiber	Myh6	IDA		Mouse	PMID:21126233
Cellular Component	GO:0030018	Z disc	Myh6	IDA		Mouse	PMID:21126233
Biological Process	GO:0030048	actin filament-based movement	Myh6	IMP	MGI:MGI:3664197	Mouse	PMID:15001446
Biological Process	GO:0030048	actin filament-based movement	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:15001446
Biological Process	GO:0007512	adult heart development	MYH6	IMP		Human	PMID:15735645
Biological Process	GO:0007512	adult heart development	MYH6	IMP		Human	PMID:15998695
Biological Process	GO:0007512	adult heart development	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:9884344
Biological Process	GO:0007512	adult heart development	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:15001446
Biological Process	GO:0007512	adult heart development	Myh6	IMP	MGI:MGI:3690300	Mouse	PMID:16983074
Biological Process	GO:0007512	adult heart development	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:10066683
Biological Process	GO:0007512	adult heart development	Myh6	IMP	MGI:MGI:3652543	Mouse	PMID:8878443
Biological Process	GO:0007512	adult heart development	Myh6	IMP	MGI:MGI:3664197	Mouse	PMID:15001446
Biological Process	GO:0007512	adult heart development	Myh6	IMP	MGI:MGI:3690299	Mouse	PMID:16983074
Biological Process	GO:0007568	aging	Myh6	IEP		Rat	PMID:1888877\|RGD:12792975
Biological Process	GO:0046034	ATP metabolic process	MYH6	IDA		Human	PMID:15621050
Biological Process	GO:0055009	atrial cardiac muscle tissue morphogenesis	MYH6	IMP		Human	PMID:15735645
Biological Process	GO:0055004	atrial cardiac myofibril assembly	myh6	IMP	ZFIN:ZDB-GENO-070808-9	Zfish	PMID:17311471
Biological Process	GO:0055004	atrial cardiac myofibril assembly	myh6	IMP	ZFIN:ZDB-GENO-980202-123	Zfish	PMID:14573521
Biological Process	GO:0003230	cardiac atrium development	myh6	IMP	ZFIN:ZDB-GENO-150916-18	Zfish	PMID:25100766
Biological Process	GO:0003209	cardiac atrium morphogenesis	myh6	IMP	ZFIN:ZDB-GENO-150831-16	Zfish	PMID:31129720
Biological Process	GO:0055013	cardiac muscle cell development	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:9884344
Biological Process	GO:0055013	cardiac muscle cell development	Myh6	IMP	MGI:MGI:3652543	Mouse	PMID:8878443
Biological Process	GO:0055013	cardiac muscle cell development	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:15001446
Biological Process	GO:0055013	cardiac muscle cell development	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:10066683
Biological Process	GO:0055013	cardiac muscle cell development	Myh6	IMP	MGI:MGI:3664197	Mouse	PMID:15001446
Biological Process	GO:0060048	cardiac muscle contraction	Myh6	IMP		Mouse	MGI:MGI:1327483\|PMID:9884344
Biological Process	GO:0014898	cardiac muscle hypertrophy in response to stress	Myh6	IDA		Mouse	PMID:24137001
Biological Process	GO:0003231	cardiac ventricle development	myh7	IGI	ZFIN:ZDB-CRISPR-221207-1	Zfish	PMID:35463789
Biological Process	GO:0003208	cardiac ventricle morphogenesis	myh6	IMP	ZFIN:ZDB-GENO-150831-16	Zfish	PMID:31129720
Biological Process	GO:1905243	cellular response to 3,3',5-triiodo-L-thyronine	Myh6	IEP		Rat	PMID:17111039\|RGD:12792968
Biological Process	GO:0035050	embryonic heart tube development	myh7	IEP		Zfish	PMID:10491254
Biological Process	GO:0060047	heart contraction	myh6	IMP	ZFIN:ZDB-GENO-070808-9	Zfish	PMID:9007249
Biological Process	GO:0060047	heart contraction	myh6	IMP	ZFIN:ZDB-GENO-130118-2	Zfish	PMID:23074141
Biological Process	GO:0060047	heart contraction	myh6	IMP	ZFIN:ZDB-GENO-070808-39	Zfish	PMID:9007249
Biological Process	GO:0060047	heart contraction	myh6	IMP	ZFIN:ZDB-GENO-980202-676	Zfish	PMID:9007249
Biological Process	GO:0060047	heart contraction	myh6	IMP	ZFIN:ZDB-MRPHLNO-061110-1	Zfish	PMID:25717017
Biological Process	GO:0060047	heart contraction	myh6	IMP	ZFIN:ZDB-GENO-070808-7	Zfish	PMID:9007249
Biological Process	GO:0003007	heart morphogenesis	myh6	IMP	ZFIN:ZDB-GENO-130118-2	Zfish	PMID:23074141
Biological Process	GO:0001701	in utero embryonic development	Myh6	IMP	MGI:MGI:3652543	Mouse	PMID:8878443
Biological Process	GO:0006936	muscle contraction	MYH6	IDA		Human	PMID:15621050
Biological Process	GO:0006936	muscle contraction	Myh6	IMP		Rat	PMID:15020307\|RGD:1581168
Biological Process	GO:0006936	muscle contraction	Myh6	IMP		Rat	PMID:15471982\|RGD:1581170
Biological Process	GO:0030049	muscle filament sliding	MYH6	IMP		Human	PMID:16088376
Biological Process	GO:0030239	myofibril assembly	Myh6	IMP	MGI:MGI:3652543	Mouse	PMID:8878443
Biological Process	GO:0030239	myofibril assembly	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:9884344
Biological Process	GO:0030239	myofibril assembly	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:10066683
Biological Process	GO:0030903	notochord development	smyhc1	IMP	ZFIN:ZDB-GENO-220603-3	Zfish	PMID:33016623
Biological Process	GO:0030903	notochord development	smyhc1	IMP	ZFIN:ZDB-GENO-220603-4	Zfish	PMID:33016623
Biological Process	GO:0030903	notochord development	smyhc1	IMP	ZFIN:ZDB-GENO-220603-2	Zfish	PMID:33016623
Biological Process	GO:0043462	regulation of ATP-dependent activity	Myh6	IMP	MGI:MGI:3664197	Mouse	PMID:15001446
Biological Process	GO:0043462	regulation of ATP-dependent activity	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:15001446
Biological Process	GO:0008217	regulation of blood pressure	Myh6	IMP	MGI:MGI:3652543	Mouse	PMID:8878443
Biological Process	GO:0008016	regulation of heart contraction	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:9045856
Biological Process	GO:0008016	regulation of heart contraction	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:9884344
Biological Process	GO:0008016	regulation of heart contraction	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:10231857
Biological Process	GO:0008016	regulation of heart contraction	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:8614836
Biological Process	GO:0008016	regulation of heart contraction	Myh6	IMP	MGI:MGI:3652543	Mouse	PMID:8878443
Biological Process	GO:0008016	regulation of heart contraction	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:10074482
Biological Process	GO:0008016	regulation of heart contraction	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:10066683
Biological Process	GO:0060420	regulation of heart growth	Myh6	IDA		Mouse	PMID:17379774
Biological Process	GO:0002027	regulation of heart rate	MYH6	IDA		Human	PMID:15621050
Biological Process	GO:0002027	regulation of heart rate	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:9541509
Biological Process	GO:0002026	regulation of the force of heart contraction	MYH6	IDA		Human	PMID:15621050
Biological Process	GO:0002026	regulation of the force of heart contraction	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:9541509
Biological Process	GO:0009408	response to heat	Myh6	IEP		Rat	PMID:22285644\|RGD:7247703
Biological Process	GO:0045214	sarcomere organization	Myh6	IMP	MGI:MGI:3652543	Mouse	PMID:8878443
Biological Process	GO:0048741	skeletal muscle fiber development	smyhc1	IMP	ZFIN:ZDB-GENO-220603-3	Zfish	PMID:33016623
Biological Process	GO:0048741	skeletal muscle fiber development	smyhc1	IMP	ZFIN:ZDB-GENO-220603-4	Zfish	PMID:33016623
Biological Process	GO:0048741	skeletal muscle fiber development	smyhc1	IMP	ZFIN:ZDB-GENO-220603-2	Zfish	PMID:33016623
Biological Process	GO:0030240	skeletal muscle thin filament assembly	smyhc1	IMP	ZFIN:ZDB-MRPHLNO-100902-2	Zfish	PMID:20049323
Biological Process	GO:0031444	slow-twitch skeletal muscle fiber contraction	smyhc1	IGI	ZFIN:ZDB-MRPHLNO-110823-3,ZFIN:ZDB-MRPHLNO-110830-1	Zfish	PMID:22075003
Biological Process	GO:0031444	slow-twitch skeletal muscle fiber contraction	smyhc2	IGI	ZFIN:ZDB-MRPHLNO-110823-3,ZFIN:ZDB-MRPHLNO-110830-1	Zfish	PMID:22075003
Biological Process	GO:0006941	striated muscle contraction	MYH6	IMP		Human	PMID:15621050
Biological Process	GO:0006941	striated muscle contraction	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:10074482
Biological Process	GO:0006941	striated muscle contraction	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:9045856
Biological Process	GO:0006941	striated muscle contraction	Myh6	IMP	MGI:MGI:3690300	Mouse	PMID:16983074
Biological Process	GO:0006941	striated muscle contraction	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:9884344
Biological Process	GO:0006941	striated muscle contraction	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:10066683
Biological Process	GO:0006941	striated muscle contraction	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:15001446
Biological Process	GO:0006941	striated muscle contraction	Myh6	IMP	MGI:MGI:3690299	Mouse	PMID:16983074
Biological Process	GO:0006941	striated muscle contraction	Myh6	IMP	MGI:MGI:3664197	Mouse	PMID:15001446
Biological Process	GO:0006941	striated muscle contraction	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:8614836
Biological Process	GO:0006941	striated muscle contraction	Myh6	IMP	MGI:MGI:3652543	Mouse	PMID:8878443
Biological Process	GO:0006941	striated muscle contraction	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:9541509
Biological Process	GO:0071688	striated muscle myosin thick filament assembly	smyhc1	IMP	ZFIN:ZDB-MRPHLNO-100902-2	Zfish	PMID:20049323
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	MYH6	IMP		Human	PMID:11815426
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	MYH6	IMP		Human	PMID:15998695
Biological Process	GO:0055005	ventricular cardiac myofibril assembly	myh7	IMP	ZFIN:ZDB-GENO-071128-1	Zfish	PMID:17311471
Biological Process	GO:0007522	visceral muscle development	Myh6	IMP	MGI:MGI:2182704	Mouse	PMID:11708849

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.