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Gene Detail
myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms A830009F23Rik, alpha cardiac MHC, alpha-MHC, alpha myosin, cardiomyopathy, hypertrophic 1, Myhca, Myhc-a
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.01 cM
Detailed Genetic Map ± 1 cM

Mapping data(11)
Sequence Map
Chr14:54952246-54966927 bp, - strand
From VEGA annotation of GRCm38

  14682 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:124414  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Myh6

Human Homolog MYH6, myosin, heavy chain 6, cardiac muscle, alpha
NCBI Gene ID 4624
neXtProt AC  NX_P13533
Human Synonyms  alpha-MHC, ASD3, CMD1EE, CMH14, MYHC, MYHCA, SSS3
Human Chr (Location)  14q12; chr14:23380733-23409622 (-)  GRCh38
Disease Associations  (5) Diseases Associated with Human MYH6
alleles, and
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a knock-out allele exhibit embryonic lethality associated with heart defects while heterozygotes show cardiac myofibrillar disarray, cardiac dysfunction and fibrosis. Mice heterozygous for different knock-in alleles may develop hypertrophic or dilated forms of cardiomyopathy.
Human Diseases Modeled Using Mouse Myh6 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(5)
Myh6 interacts with 45 markers (Mir1a-1, Mir1a-2, Mir22, ...)
Gene Ontology
All GO classifications: (66 annotations)
Process actin filament-based movement, adult heart development, ...
Component cytoplasm, focal adhesion, ...
Function actin binding, actin-dependent ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (82 records)
Data Summary: Results (154)    Tissues (36)    Images (46)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 104
Northern blot 5
cDNA source data(11)
External Resources: GEO   Expression Atlas
All nucleic(27) Genomic(1) cDNA(13) Primer pair(8) Other(5)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000016384 (Evidence)
Ensembl Gene ModelENSMUSG00000040752 (Evidence)
Entrez Gene17888 (Evidence)
DFCITC1577524, TC1610322
DoTSDT.101310310, DT.110747575, DT.110747576, DT.110747601, DT.60173600, DT.91390078, DT.91417865
Consensus CDS ProjectCCDS36927.1
International Mouse Knockout Project StatusMyh6
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016384 VEGA Gene Model | MGI Sequence Detail 14682 C57BL/6J ±  kb
transcript OTTMUST00000039447 VEGA | MGI Sequence Detail 3578 Not Applicable 
polypeptide OTTMUSP00000017624 VEGA | MGI Sequence Detail 1114 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(8) UniProt(11)
Polymorphisms RFLP(7) : SNPs within 2kb(371 from dbSNP Build 137)    SNPs within 2kb including multiple locations(379)
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR004009 Myosin, N-terminal, SH3-like
InterPro IPR008989 Myosin S1 fragment, N-terminal
InterPro IPR002928 Myosin tail
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010829 myosin-6
References (Earliest) J:8079 Weydert A, et al., Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7183-7
(Latest) J:206594 Daou N, et al., A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis. Development. 2013 Dec;140(24):4914-25
All references(172)
Disease annotation references (4)
accession IDs
MGD-MRK-12741, MGD-MRK-12743, MGI:2145563

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory