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Myh6
Gene Detail
 Symbol
Name
ID
Myh6
myosin, heavy polypeptide 6, cardiac muscle, alpha
MGI:97255
Synonyms A830009F23Rik, alpha cardiac MHC, alpha-MHC, alpha myosin, cardiomyopathy, hypertrophic 1, Myhca, Myhc-a
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr14:54952246-54966927 bp, - strand
From VEGA annotation of GRCm38

  14682 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:124414  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Myh6

Human
homologs
Human Homolog MYH6, myosin, heavy chain 6, cardiac muscle, alpha
NCBI Gene ID 4624
neXtProt AC  NX_P13533
Human Synonyms  alpha-MHC, ASD3, CMD1EE, CMH14, MYHC, MYHCA, SSS3
Human Chr (Location)  14q12; chr14:23380733-23409622 (-)  GRCh38
Disease Associations  (5) Diseases Associated with Human MYH6
Alleles
and
phenotypes
All alleles(8) : Targeted(8)
 
Mice homozygous for a knock-out allele exhibit embryonic lethality associated with heart defects while heterozygotes show cardiac myofibrillar disarray, cardiac dysfunction and fibrosis. Mice heterozygous for different knock-in alleles may develop hypertrophic or dilated forms of cardiomyopathy.
 
Human Diseases Modeled Using Mouse Myh6 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(5)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process actin filament-based movement, adult heart development, ...
Component cytoplasm, focal adhesion, ...
Function actin binding, actin-dependent ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (81 records)
Data Summary: Results (150)    Tissues (34)    Images (44)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 104
Northern blot 5
RT-PCR 33
cDNA source data(11)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(13) Primer pair(7) Other(5)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016384 (Evidence)
Ensembl Gene ModelENSMUSG00000040752 (Evidence)
Entrez Gene17888 (Evidence)
DFCITC1577524, TC1610322
DoTSDT.101310310, DT.110747575, DT.110747576, DT.110747601, DT.60173600, DT.91390078, DT.91417865
Consensus CDS ProjectCCDS36927.1
International Mouse Knockout Project StatusMyh6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016384 VEGA Gene Model | MGI Sequence Detail 14682 C57BL/6J ±  kb
transcript OTTMUST00000039447 VEGA | MGI Sequence Detail 3578 Not Applicable 
polypeptide OTTMUSP00000017624 VEGA | MGI Sequence Detail 1114 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(8) UniProt(11)
Polymorphisms RFLP(7) : SNPs within 2kb(371 from dbSNP Build 137)    SNPs within 2kb including multiple locations(379)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR015650 Myosin class 1/2/3/4/7/8/13/15
InterPro IPR001609 Myosin head, motor domain
InterPro IPR027401 Myosin-like IQ motif-containing domain
InterPro IPR004009 Myosin, N-terminal, SH3-like
InterPro IPR008989 Myosin S1 fragment, N-terminal
InterPro IPR002928 Myosin tail
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010829 myosin-6
References (Earliest) J:8079 Weydert A, et al., Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7183-7
(Latest) J:202826 Kasahara A, et al., Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling. Science. 2013 Nov 8;342(6159):734-7
All references(170)
Other
accession IDs
MGD-MRK-12741, MGD-MRK-12743, MGI:2145563

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory