Phenotypes Associated with This Genotype

Genotype
MGI:3691282

• Allelic Composition: Myh6^tm2Ces/Myh6⁺
• Genetic Background: involves: 129S/SvEv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

dilated heart left ventricle ( J:114549 )

• show a gradual increase in left ventricle chamber size in some mutants by 12 weeks of age and in all mutants by 50 weeks of age

dilated cardiomyopathy ( J:114549 )

• exhibit a gradual development of dilated cardiomyopathy that is less pronounced than in Myh6^tm1Ces heterozygotes

decreased cardiac muscle contractility ( J:114549 )

• isolated cardiac myocytes from 8-week old mutants have impaired contractile function, as indicated by reduced extent and rate of shortening, however to a lesser extent that in homozygotes

muscle

dilated cardiomyopathy ( J:114549 )

• exhibit a gradual development of dilated cardiomyopathy that is less pronounced than in Myh6^tm1Ces heterozygotes

decreased cardiac muscle contractility ( J:114549 )

• isolated cardiac myocytes from 8-week old mutants have impaired contractile function, as indicated by reduced extent and rate of shortening, however to a lesser extent that in homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1EE		DOID:0110453	OMIM:613252	J:114549