Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Mstn

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MSTN
- Mouse genes Mstn
- Rat genes Mstn
- Zfish genes mstnb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mstn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008083	growth factor activity	mstnb	IDA		Zfish	PMID:15042708
Molecular Function	GO:0008201	heparin binding	Mstn	IDA		Mouse	MGI:MGI:5905208\|PMID:28257634
Molecular Function	GO:0008201	heparin binding	Mstn	IDA		Mouse	MGI:MGI:5805364\|PMID:19644449
Molecular Function	GO:0042802	identical protein binding	MSTN	IPI	UniProtKB:O14793	Human	PMID:23829672
Molecular Function	GO:0042802	identical protein binding	MSTN	IDA		Human	PMID:27625211
Molecular Function	GO:0042802	identical protein binding	MSTN	IPI	UniProtKB:O14793	Human	PMID:29330193
Molecular Function	GO:0042802	identical protein binding	Mstn	IDA		Mouse	MGI:MGI:5905208\|PMID:28257634
Molecular Function	GO:0005515	protein binding	MSTN	IPI	UniProtKB:Q8TEU8	Human	PMID:12595574
Molecular Function	GO:0005515	protein binding	MSTN	IPI	UniProtKB:P09958	Human	PMID:23829672
Molecular Function	GO:0005515	protein binding	MSTN	IPI	UniProtKB:P13497	Human	PMID:23829672
Molecular Function	GO:0005515	protein binding	MSTN	IPI	UniProtKB:Q13705	Human	PMID:23829672
Molecular Function	GO:0005515	protein binding	MSTN	IPI	UniProtKB:Q96NZ8	Human	PMID:23829672
Molecular Function	GO:0005515	protein binding	MSTN	IPI	UniProtKB:P09958	Human	PMID:25543063
Molecular Function	GO:0005515	protein binding	MSTN	IPI	UniProtKB:P13497	Human	PMID:25543063
Molecular Function	GO:0005515	protein binding	Mstn	IPI	PR:Q7TQN3	Mouse	PMID:12595574
Molecular Function	GO:0005515	protein binding	Mstn	IPI	UniProtKB:Q96NZ8	Mouse	PMID:18596030
Molecular Function	GO:0005515	protein binding	Mstn	IPI	UniProtKB:Q8TEU8	Mouse	PMID:18596030
Molecular Function	GO:0042803	protein homodimerization activity	Mstn	IDA		Mouse	MGI:MGI:5805364\|PMID:19644449
Molecular Function	GO:0005102	signaling receptor binding	MSTN	IPI	UniProtKB:P36896	Human	PMID:14517293
Molecular Function	GO:0005102	signaling receptor binding	MSTN	IPI	UniProtKB:P36897	Human	PMID:14517293
Molecular Function	GO:0005102	signaling receptor binding	MSTN	IPI	UniProtKB:Q13705	Human	PMID:14517293
Molecular Function	GO:0005102	signaling receptor binding	Mstn	IPI	PR:P27040	Mouse	PMID:11459935
Molecular Function	GO:0005102	signaling receptor binding	Mstn	IPI	PR:P27038	Mouse	PMID:11459935
Cellular Component	GO:0005737	cytoplasm	Mstn	IDA		Rat	PMID:17679144\|RGD:2303553
Cellular Component	GO:0005615	extracellular space	MSTN	IDA		Human	PMID:12595574
Cellular Component	GO:0005615	extracellular space	Mstn	IDA		Mouse	MGI:MGI:2676508\|PMID:12595574
Cellular Component	GO:0005615	extracellular space	Mstn	IDA		Rat	PMID:16575154\|RGD:1601299
Biological Process	GO:0110021	cardiac muscle myoblast proliferation	mstnb	IMP	ZFIN:ZDB-GENO-181121-4	Zfish	PMID:29196619
Biological Process	GO:0110021	cardiac muscle myoblast proliferation	mstnb	IMP	ZFIN:ZDB-GENO-181121-3	Zfish	PMID:29196619
Biological Process	GO:0071549	cellular response to dexamethasone stimulus	Mstn	IDA		Mouse	PMID:23752591
Biological Process	GO:0006955	immune response	mstnb	IMP	ZFIN:ZDB-GENO-180712-6	Zfish	PMID:29175471
Biological Process	GO:0046716	muscle cell cellular homeostasis	MSTN	IDA		Human	PMID:19357233
Biological Process	GO:0007517	muscle organ development	mstnb	IDA		Zfish	PMID:15042708
Biological Process	GO:0014839	myoblast migration involved in skeletal muscle regeneration	Mstn	IMP		Mouse	MGI:MGI:3850794\|PMID:19406121
Biological Process	GO:0110023	negative regulation of cardiac muscle myoblast proliferation	mstnb	IMP	ZFIN:ZDB-GENO-181121-3	Zfish	PMID:29196619
Biological Process	GO:0045926	negative regulation of growth	mstnb	IDA		Zfish	PMID:15042708\|ZFIN:ZDB-PUB-040326-2
Biological Process	GO:0045926	negative regulation of growth	mstnb	IDA		Zfish	PMID:14555747\|ZFIN:ZDB-PUB-031014-1
Biological Process	GO:0045967	negative regulation of growth rate	mstnb	IDA		Zfish	PMID:15042708
Biological Process	GO:0046627	negative regulation of insulin receptor signaling pathway	Mstn	IMP		Mouse	MGI:MGI:3604221\|PMID:16182246
Biological Process	GO:0033673	negative regulation of kinase activity	Mstn	IMP		Mouse	MGI:MGI:5619470\|PMID:19357233
Biological Process	GO:0014741	negative regulation of muscle hypertrophy	Mstn	IMP		Rat	PMID:16810717\|RGD:2303557
Biological Process	GO:0045662	negative regulation of myoblast differentiation	MSTN	IDA		Human	PMID:19357233
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	MSTN	IDA		Human	PMID:19357233
Biological Process	GO:0048642	negative regulation of skeletal muscle tissue development	mstnb	IMP	ZFIN:ZDB-GENO-180321-1	Zfish	PMID:27458428
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	MSTN	IMP		Human	PMID:15215484
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	Mstn	IMP		Mouse	MGI:MGI:2176357\|PMID:11877467
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	Mstn	IMP		Mouse	MGI:MGI:5544527\|PMID:24076600
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	Mstn	IMP		Mouse	MGI:MGI:87393\|PMID:9139826
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	Mstn	IMP		Mouse	MGI:MGI:4948370\|PMID:21390326
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	Mstn	IMP	MGI:MGI:3778375	Mouse	PMID:18286185
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	Mstn	IMP	MGI:MGI:2148177	Mouse	PMID:18286185
Biological Process	GO:0048632	negative regulation of skeletal muscle tissue growth	Mstn	IMP		Rat	PMID:16575154\|RGD:1601299
Biological Process	GO:0045843	negative regulation of striated muscle tissue development	mstnb	IDA		Zfish	PMID:15042708\|ZFIN:ZDB-PUB-040326-2
Biological Process	GO:0022602	ovulation cycle process	Mstn	IEP		Rat	PMID:18845635\|RGD:2303546
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MSTN	IDA		Human	PMID:14517293
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	Mstn	IMP		Mouse	MGI:MGI:3850794\|PMID:19406121
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	Mstn	IMP		Mouse	MGI:MGI:3850794\|PMID:19406121
Biological Process	GO:0014738	regulation of muscle hyperplasia	mstnb	IMP	ZFIN:ZDB-GENO-180712-6	Zfish	PMID:29175471
Biological Process	GO:0051602	response to electrical stimulus	Mstn	IEP		Rat	PMID:18787495\|RGD:2303548
Biological Process	GO:0043627	response to estrogen	Mstn	IEP		Rat	PMID:18845635\|RGD:2303546
Biological Process	GO:0045471	response to ethanol	Mstn	IEP		Rat	PMID:14749210\|RGD:2303597
Biological Process	GO:0051384	response to glucocorticoid	Mstn	IEP		Rat	PMID:16919545\|RGD:2303555
Biological Process	GO:0009629	response to gravity	Mstn	IEP		Rat	PMID:11115768\|RGD:2303600
Biological Process	GO:0009408	response to heat	Mstn	IEP		Rat	PMID:11481237\|RGD:2303598
Biological Process	GO:0014850	response to muscle activity	Mstn	IEP		Rat	PMID:15743390\|RGD:2303595
Biological Process	GO:0033574	response to testosterone	Mstn	IEP		Rat	PMID:18841527\|RGD:2303547
Biological Process	GO:0014732	skeletal muscle atrophy	Mstn	IEP		Rat	PMID:15758361\|RGD:2303594
Biological Process	GO:0014816	skeletal muscle satellite cell differentiation	Mstn	IMP		Mouse	PMID:26923583
Biological Process	GO:0007519	skeletal muscle tissue development	mstnb	IDA		Zfish	PMID:19517013
Biological Process	GO:0043403	skeletal muscle tissue regeneration	Mstn	IMP		Mouse	PMID:26923583
Biological Process	GO:0043403	skeletal muscle tissue regeneration	Mstn	IEP		Rat	PMID:11206133\|RGD:2303599
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	Mstn	IDA		Mouse	PMID:12595574
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	mstnb	IDA		Zfish	PMID:14555747\|ZFIN:ZDB-PUB-031014-1
Biological Process	GO:0003222	ventricular trabecula myocardium morphogenesis	mstnb	IMP	ZFIN:ZDB-GENO-181121-3	Zfish	PMID:29196619

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.