Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MGRN1
  • Mouse genes Mgrn1
  • Rat genes Mgrn1
  • Zfish genes mgrn1a,mgrn1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mgrn1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	MGRN1	IPI	UniProtKB:Q99816	Human	PMID:17229889
Molecular Function	GO:0005515	protein binding	MGRN1	IPI	UniProtKB:Q99816	Human	PMID:19549727
Molecular Function	GO:0005515	protein binding	MGRN1	IPI	UniProtKB:P32245	Human	PMID:19737927
Molecular Function	GO:0005515	protein binding	MGRN1	IPI	UniProtKB:Q01726	Human	PMID:19737927
Molecular Function	GO:0005515	protein binding	MGRN1	IPI	UniProtKB:Q99816	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	MGRN1	IPI	UniProtKB:Q99816	Human	PMID:35044719
Molecular Function	GO:0005515	protein binding	Mgrn1	IPI	UniProtKB:O00213	Mouse	MGI:MGI:5818433|PMID:25342469
Molecular Function	GO:0005515	protein binding	Mgrn1	IPI	UniProtKB:O81775	Rat	PMID:24036454|RGD:8553341
Molecular Function	GO:0061630	ubiquitin protein ligase activity	Mgrn1	IDA		Mouse	PMID:12560552
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	MGRN1	IDA		Human	PMID:17229889
Molecular Function	GO:0004842	ubiquitin-protein transferase activity	MGRN1	IDA		Human	PMID:19737927
Cellular Component	GO:0005737	cytoplasm	MGRN1	IDA		Human	PMID:17229889
Cellular Component	GO:0005737	cytoplasm	MGRN1	IDA		Human	PMID:19737927
Cellular Component	GO:0005769	early endosome	MGRN1	IDA		Human	PMID:17229889
Cellular Component	GO:0005783	endoplasmic reticulum	MGRN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0070062	extracellular exosome	MGRN1	HDA		Human	PMID:19056867
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	MGRN1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0016020	membrane	MGRN1	HDA		Human	PMID:19946888
Cellular Component	GO:0005634	nucleus	MGRN1	IDA		Human	PMID:17229889
Biological Process	GO:0008333	endosome to lysosome transport	MGRN1	IMP		Human	PMID:17229889
Biological Process	GO:0043951	negative regulation of cAMP-mediated signaling	MGRN1	IDA		Human	PMID:19737927
Biological Process	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	MGRN1	IDA		Human	PMID:19737927
Biological Process	GO:0045879	negative regulation of smoothened signaling pathway	Mgrn1	IMP		Mouse	MGI:MGI:6111022|PMID:29290584
Biological Process	GO:0006513	protein monoubiquitination	MGRN1	IMP		Human	PMID:17229889
Biological Process	GO:0000209	protein polyubiquitination	Mgrn1	IDA		Mouse	PMID:12560552

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern