| GO term: | negative regulation of smoothened signaling pathway |
| Synonym: | down regulation of smoothened signaling pathway |
| Synonym: | down-regulation of smoothened signaling pathway |
| Synonym: | downregulation of smoothened signaling pathway |
| Synonym: | inhibition of smoothened signaling pathway |
| Synonym: | negative regulation of hedgehog signaling pathway |
| Synonym: | negative regulation of hh signaling pathway |
| Synonym: | negative regulation of smoothened activity |
| Synonym: | negative regulation of smoothened by patched |
| Synonym: | negative regulation of smoothened receptor activity by patched |
| Synonym: | negative regulation of smoothened signalling pathway |
| GO id: | GO:0045879 |
| Definition: | Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling. |
| Number of paths to term: | 104 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of cellular processnegative regulation of cell communicationnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of response to stimulusnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of signalingnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of cellular processnegative regulation of cellular processnegative regulation of cell communicationnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cell communicationnegative regulation of cell communicationnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cell communicationregulation of signal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cell communicationregulation of signal transductionregulation of smoothened signaling pathwaynegative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +positive regulation of smoothened signaling pathway +regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwaysmoothened signaling pathwayciliary receptor clustering involved in smoothened signaling pathwaymesenchymal smoothened signaling pathway involved in prostate gland developmentnegative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +positive regulation of smoothened signaling pathway +regulation of smoothened signaling pathway +signal transduction downstream of smoothened +smoothened signaling pathway involved in dorsal/ventral neural tube patterning +smoothened signaling pathway involved in growth plate cartilage chondrocyte developmentsmoothened signaling pathway involved in lung developmentsmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationsmoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferationsmoothened signaling pathway involved in ventral spinal cord patterning +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwaysmoothened signaling pathwayregulation of smoothened signaling pathwaynegative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +positive regulation of smoothened signaling pathway +regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionregulation of signal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionregulation of signal transductionregulation of smoothened signaling pathwaynegative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +positive regulation of smoothened signaling pathway +regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +biological_processbiological regulationregulation of biological processregulation of response to stimulusnegative regulation of response to stimulusnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of response to stimulusregulation of signal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of response to stimulusregulation of signal transductionregulation of smoothened signaling pathwaynegative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +positive regulation of smoothened signaling pathway +regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +biological_processbiological regulationregulation of biological processregulation of signalingnegative regulation of signalingnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of signalingregulation of signal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of signalingregulation of signal transductionregulation of smoothened signaling pathwaynegative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +positive regulation of smoothened signaling pathway +regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +biological_processcellular processnegative regulation of cellular processnegative regulation of cell communicationnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processcellular processregulation of cellular processnegative regulation of cellular processnegative regulation of cell communicationnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processcellular processregulation of cellular processregulation of cell communicationnegative regulation of cell communicationnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processcellular processregulation of cellular processregulation of cell communicationregulation of signal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processcellular processregulation of cellular processregulation of cell communicationregulation of signal transductionregulation of smoothened signaling pathwaynegative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +positive regulation of smoothened signaling pathway +regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +biological_processcellular processregulation of cellular processsignal transductioncell surface receptor signaling pathwaysmoothened signaling pathwayciliary receptor clustering involved in smoothened signaling pathwaymesenchymal smoothened signaling pathway involved in prostate gland developmentnegative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +positive regulation of smoothened signaling pathway +regulation of smoothened signaling pathway +signal transduction downstream of smoothened +smoothened signaling pathway involved in dorsal/ventral neural tube patterning +smoothened signaling pathway involved in growth plate cartilage chondrocyte developmentsmoothened signaling pathway involved in lung developmentsmoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationsmoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferationsmoothened signaling pathway involved in ventral spinal cord patterning +biological_processcellular processregulation of cellular processsignal transductioncell surface receptor signaling pathwaysmoothened signaling pathwayregulation of smoothened signaling pathwaynegative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +positive regulation of smoothened signaling pathway +regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +biological_processcellular processregulation of cellular processsignal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processcellular processregulation of cellular processsignal transductionregulation of signal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processcellular processregulation of cellular processsignal transductionregulation of signal transductionregulation of smoothened signaling pathwaynegative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +positive regulation of smoothened signaling pathway +regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning +biological_processcellular processsingle-organism cellular processcell communicationnegative regulation of cell communicationnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processcellular processsingle-organism cellular processcell communicationregulation of cell communicationnegative regulation of cell communicationnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway [GO:0045879] (20 genes, 28 annotations)negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningnegative regulation of smoothened signaling pathway involved in ventral spinal cord patterning +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processcellular processsingle-organism cellular processcell communicationregulation of cell communicationregulation of signal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway +negative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathway
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