Mgrn1
Gene Detail

Symbol Name ID

Mgrn1 mahogunin, ring finger 1 MGI:2447670

Synonyms

2610042J20Rik, mKIAA0544, nc

Feature Type

protein coding gene

Genetic Map

Chromosome 16

2.48 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(24)

Sequence Map

Chr16:4886100-4938296 bp, + strand From NCBI annotation of GRCm38   52197 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41020  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mgrn1

Human homologs

Human Homolog		MGRN1, mahogunin ring finger 1, E3 ubiquitin protein ligase
NCBI Gene ID		23295
neXtProt AC		NX_O60291
Human Synonyms		RNF156
Human Chr (Location)		16p13.3; chr16:4674825-4740975 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(62) : Targeted(4) Gene trapped(52) Spontaneous(5) Chemically induced(1)
 

Homozygotes for mutant alleles exhibit darkening of agouti hair and suppression of the obesity associated with certain agouti mutations. Homozygotes for an induced null mutation also have curly whiskers and develop a progressive spongiform neuropathology.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	endosome to lysosome transport, negative regulation of cAMP-mediated signaling, ...
Component	cytoplasm, early endosome, ...
Function	ligase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (73)    Tissues (46)    Images (3)
Theiler Stages: 21, 23, 28

Assay Type	Results
RNA in situ	53
RT-PCR	20

cDNA source data(175)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(176) cDNA(175) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000022517 (Evidence)
Entrez Gene	17237 (Evidence)
UniGene	291326
NIA Mouse Gene Index	U016766
EC	6.3.2.-
Consensus CDS Project	CCDS49751.1, CCDS57016.1
International Mouse Knockout Project Status	Mgrn1

Sequences

Length	Strain/Species
genomic	17237	NCBI Gene Model | MGI Sequence Detail	52197	C57BL/6J
transcript	NM_001252437	RefSeq | MGI Sequence Detail	3293	C57BL/6
polypeptide	Q9D074	UniProt | EBI | MGI Sequence Detail	532	Not Applicable

All sequences(85) RefSeq(4) UniProt(1)

Polymorphisms

SNPs(123 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
Protein Ontology	PR:000030848	E3 ubiquitin-protein ligase MGRN1

Graphical View of Protein Domain Structure

References

(Earliest) J:13379 Lane PW, mahoganoid, md. Mouse News Lett. 1960;22:35
(Latest) J:178348 Cooray SN, et al., The E3 ubiquitin ligase Mahogunin ubiquitinates the melanocortin 2 receptor. Endocrinology. 2011 Nov;152(11):4224-31
All references(77)

Other accession IDs

MGD-MRK-12160, MGD-MRK-12784, MGI:1923814, MGI:2146731, MGI:96946