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Mgrn1
Gene Detail
Symbol

Name
ID
Mgrn1
mahogunin, ring finger 1
MGI:2447670
Synonyms
2610042J20Rik, mKIAA0544, nc
Feature Type
protein coding gene
Genetic Map
Chromosome 16
2.48 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr16:4886100-4938296 bp, + strand
From NCBI annotation of GRCm38

  52197 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41020  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: MGRN1
Gene Tree: Mgrn1

Human
homologs
MGRN1, mahogunin ring finger 1, E3 ubiquitin protein ligase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23295
neXtProt AC: NX_O60291

Human Synonyms: RNF156

Human Chr (Location): 16p13.3; chr16:4616493-4690974 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(62) : Chemically induced (other)(1) Gene trapped(52) Spontaneous(5) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for mutant alleles exhibit darkening of agouti hair and suppression of the obesity associated with certain agouti mutations. Homozygotes for an induced null mutation also have curly whiskers and develop a progressive spongiform neuropathology.
 
Phenotype Images(1)
Interactions
Mgrn1 interacts with 200 markers (Mir15a, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (95)    Tissues (59)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 57
In situ reporter (knock in) 18
RT-PCR 20
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mgrn1 ; ZFIN mgrn1a    NEW 
Molecular
reagents
All nucleic(12) cDNA(10) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000022517 (Evidence)
Entrez Gene 17237 (Evidence)
NIA Mouse Gene Index U016766
EC 6.3.2.-
Consensus CDS Project CCDS49751.1, CCDS57016.1
International Mouse Phenotyping Consortium Status Mgrn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17237 NCBI Gene Model | MGI Sequence Detail 52197 C57BL/6J ±  kb
transcript NM_001252437 RefSeq | MGI Sequence Detail 3293 C57BL/6 
polypeptide Q9D074 UniProt | EBI | MGI Sequence Detail 532 Not Applicable 

For the selected sequences
All sequences(106) RefSeq(18) UniProt(1)
Polymorphisms
SNPs within 2kb(191 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000030848 E3 ubiquitin-protein ligase MGRN1
Graphical View of Protein Domain Structure
References
(Earliest) J:13379 Lane PW, mahoganoid, md. Mouse News Lett. 1960;22:35
(Latest) J:195780 Silvius D, et al., Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease. PLoS One. 2013;8(1):e55575
All references(76)
Other
accession IDs
MGD-MRK-12160, MGD-MRK-12784, MGI:1923814, MGI:2146731, MGI:96946

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory