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Mgrn1 Gene Detail
Summary
  • Symbol
    Mgrn1
  • Name
    mahogunin, ring finger 1
  • Synonyms
    2610042J20Rik, mKIAA0544, nc
  • Feature Type
    protein coding gene
  • IDs
    MGI:2447670
    NCBI Gene: 17237
Location & Maps
more
  • Sequence Map
    Chr16:4886100-4938296 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52197 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MGRN1, mahogunin ring finger 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MGRN1, mahogunin ring finger 1
    Orthology source: HomoloGene
  • Synonyms
    RNF156
  • Links
    NCBI Gene ID: 23295
    neXtProt AC: NX_O60291

  • Chr Location
    16p13.3; chr16:4616493-4690974 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 7 alleles in 10 genetic backgrounds
    1 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    62
  • Chemically induced (other)
    1
  • Gene trapped
    52
  • Spontaneous
    5
  • Targeted
    4
  • Incidental Mutations
Homozygotes for mutant alleles exhibit darkening of agouti hair and suppression of the obesity associated with certain agouti mutations. Homozygotes for an induced null mutation also have curly whiskers and develop a progressive spongiform neuropathology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17237 NCBI Gene Model | MGI Sequence Detail 52197 C57BL/6J ±  kb
transcript NM_001252437 RefSeq | MGI Sequence Detail 3293 C57BL/6  
polypeptide Q9D074 UniProt | EBI | MGI Sequence Detail 532 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    191 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-12160, MGD-MRK-12784, MGI:1923814, MGI:2146731, MGI:96946
References
more
  • Summaries
    All 75
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 30
  • Earliest
    J:13379 Lane PW, mahoganoid, md. Mouse News Lett. 1960;22:35
  • Latest
    J:195780 Silvius D, et al., Levels of the Mahogunin Ring Finger 1 E3 ubiquitin ligase do not influence prion disease. PLoS One. 2013;8(1):e55575

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory