| GO term: | negative regulation of G-protein coupled receptor protein signaling pathway |
| Synonym: | down regulation of G-protein coupled receptor protein signaling pathway |
| Synonym: | down-regulation of G-protein coupled receptor protein signaling pathway |
| Synonym: | downregulation of G-protein coupled receptor protein signaling pathway |
| Synonym: | inhibition of G-protein coupled receptor protein signaling pathway |
| Synonym: | negative regulation of GPCR protein signaling pathway |
| Synonym: | negative regulation of GPCR protein signalling pathway |
| Synonym: | negative regulation of G protein coupled receptor protein signaling pathway |
| Synonym: | negative regulation of G-protein-coupled receptor protein signaling pathway |
| Synonym: | negative regulation of G protein coupled receptor protein signalling pathway |
| Synonym: | negative regulation of G-protein coupled receptor protein signalling pathway |
| Synonym: | negative regulation of G-protein-coupled receptor protein signalling pathway |
| GO id: | GO:0045744 |
| Definition: | Any process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity. |
| Number of paths to term: | 104 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of cellular processnegative regulation of cell communicationnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of response to stimulusnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processnegative regulation of biological processnegative regulation of signalingnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of cellular processnegative regulation of cellular processnegative regulation of cell communicationnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cell communicationnegative regulation of cell communicationnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cell communicationregulation of signal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cell communicationregulation of signal transductionregulation of G-protein coupled receptor protein signaling pathwaycross-receptor inhibition within G-protein coupled receptor heterodimermodulation by host of symbiont G-protein coupled receptor protein signal transduction +modulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C deactivationregulation of adenosine receptor signaling pathway +regulation of adrenergic receptor signaling pathway +regulation of dopamine receptor signaling pathway +regulation of endocannabinoid signaling pathwayregulation of G-protein coupled receptor protein signaling pathway in response to host +regulation of octopamine or tyramine signaling pathway +regulation of opioid receptor signaling pathway +regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion +regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +regulation of proteinase activated receptor activity +regulation of rhodopsin mediated signaling pathway +regulation of thrombin receptor signaling pathway +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayadrenergic receptor signaling pathway +angiotensin-mediated signaling pathway +apelin receptor signaling pathwaybombesin receptor signaling pathwaycannabinoid signaling pathway +complement component C5a signaling pathwaydimeric G-protein coupled receptor signaling pathway +dopamine receptor signaling pathway +endothelin receptor signaling pathway +epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayfollicle-stimulating hormone signaling pathwayG-protein coupled acetylcholine receptor signaling pathway +G-protein coupled glutamate receptor signaling pathway +G-protein coupled purinergic receptor signaling pathway +G-protein coupled receptor signaling in absence of ligandG-protein coupled receptor signaling pathway involved in heart process +G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger +G-protein coupled receptor signaling pathway, coupled to S1P second messengergamma-aminobutyric acid signaling pathwayheterotrimeric G-protein complex cycleluteinizing hormone signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwayneuropeptide signaling pathwayoctopamine or tyramine signaling pathway +opioid receptor signaling pathway +pheromone-dependent signal transduction involved in conjugation with cellular fusion +phospholipase C-activating G-protein coupled receptor signaling pathway +phospholipase C-inhibiting G-protein coupled receptor signaling pathwayphospholipase D-activating G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C-activating G-protein coupled receptor signaling pathwayregulation of G-protein coupled receptor protein signaling pathway +rhodopsin mediated signaling pathway +serotonin receptor signaling pathway +signal transduction involved in conjugation with mutual genetic exchangesomatostatin receptor signaling pathway +sphingosine-1-phosphate signaling pathway +tachykinin receptor signaling pathway +thrombin receptor signaling pathway +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductioncell surface receptor signaling pathwayG-protein coupled receptor signaling pathwayregulation of G-protein coupled receptor protein signaling pathwaycross-receptor inhibition within G-protein coupled receptor heterodimermodulation by host of symbiont G-protein coupled receptor protein signal transduction +modulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C deactivationregulation of adenosine receptor signaling pathway +regulation of adrenergic receptor signaling pathway +regulation of dopamine receptor signaling pathway +regulation of endocannabinoid signaling pathwayregulation of G-protein coupled receptor protein signaling pathway in response to host +regulation of octopamine or tyramine signaling pathway +regulation of opioid receptor signaling pathway +regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion +regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +regulation of proteinase activated receptor activity +regulation of rhodopsin mediated signaling pathway +regulation of thrombin receptor signaling pathway +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionregulation of signal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionregulation of signal transductionregulation of G-protein coupled receptor protein signaling pathwaycross-receptor inhibition within G-protein coupled receptor heterodimermodulation by host of symbiont G-protein coupled receptor protein signal transduction +modulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C deactivationregulation of adenosine receptor signaling pathway +regulation of adrenergic receptor signaling pathway +regulation of dopamine receptor signaling pathway +regulation of endocannabinoid signaling pathwayregulation of G-protein coupled receptor protein signaling pathway in response to host +regulation of octopamine or tyramine signaling pathway +regulation of opioid receptor signaling pathway +regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion +regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +regulation of proteinase activated receptor activity +regulation of rhodopsin mediated signaling pathway +regulation of thrombin receptor signaling pathway +biological_processbiological regulationregulation of biological processregulation of response to stimulusnegative regulation of response to stimulusnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of response to stimulusregulation of signal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of response to stimulusregulation of signal transductionregulation of G-protein coupled receptor protein signaling pathwaycross-receptor inhibition within G-protein coupled receptor heterodimermodulation by host of symbiont G-protein coupled receptor protein signal transduction +modulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C deactivationregulation of adenosine receptor signaling pathway +regulation of adrenergic receptor signaling pathway +regulation of dopamine receptor signaling pathway +regulation of endocannabinoid signaling pathwayregulation of G-protein coupled receptor protein signaling pathway in response to host +regulation of octopamine or tyramine signaling pathway +regulation of opioid receptor signaling pathway +regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion +regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +regulation of proteinase activated receptor activity +regulation of rhodopsin mediated signaling pathway +regulation of thrombin receptor signaling pathway +biological_processbiological regulationregulation of biological processregulation of signalingnegative regulation of signalingnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of signalingregulation of signal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processbiological regulationregulation of biological processregulation of signalingregulation of signal transductionregulation of G-protein coupled receptor protein signaling pathwaycross-receptor inhibition within G-protein coupled receptor heterodimermodulation by host of symbiont G-protein coupled receptor protein signal transduction +modulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaypositive regulation of G-protein coupled receptor protein signaling pathway +protein kinase C deactivationregulation of adenosine receptor signaling pathway +regulation of adrenergic receptor signaling pathway +regulation of dopamine receptor signaling pathway +regulation of endocannabinoid signaling pathwayregulation of G-protein coupled receptor protein signaling pathway in response to host +regulation of octopamine or tyramine signaling pathway +regulation of opioid receptor signaling pathway +regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion +regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +regulation of proteinase activated receptor activity +regulation of rhodopsin mediated signaling pathway +regulation of thrombin receptor signaling pathway +biological_processcellular processnegative regulation of cellular processnegative regulation of cell communicationnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processcellular processregulation of cellular processnegative regulation of cellular processnegative regulation of cell communicationnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processcellular processregulation of cellular processregulation of cell communicationnegative regulation of cell communicationnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processcellular processregulation of cellular processregulation of cell communicationregulation of signal transductionnegative regulation of signal transductionextracellular negative regulation of signal transduction +inactivation of MAPK activity involved in osmosensory signaling pathwaymetarhodopsin inactivationnegative adaptation of signaling pathway +negative regulation by symbiont of host cAMP-mediated signal transduction +negative regulation by symbiont of host salicylic acid-mediated defense response +negative regulation of abscisic acid mediated signaling pathwaynegative regulation of antigen receptor-mediated signaling pathway +negative regulation of apoptotic signaling pathway +negative regulation of auxin mediated signaling pathwaynegative regulation of brain-derived neurotrophic factor receptor signaling pathway +negative regulation of brassinosteroid mediated signaling pathwaynegative regulation of calcium-mediated signaling +negative regulation of cAMP-mediated signaling +negative regulation of CD40 signaling pathwaynegative regulation of cGMP-mediated signalingnegative regulation of cytokine-mediated signaling pathway +negative regulation of cytokinin mediated signaling pathwaynegative regulation of endoplasmic reticulum unfolded protein responsenegative regulation of ephrin receptor signaling pathwaynegative regulation of ERBB signaling pathway +negative regulation of Fas signaling pathwaynegative regulation of fibroblast growth factor receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +negative regulation of thrombin receptor signaling pathwaytermination of G-protein coupled receptor signaling pathwaynegative regulation of gibberellic acid mediated signaling pathwaynegative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationnegative regulation of glucocorticoid mediated signaling pathwaynegative regulation of glutamate receptor signaling pathwaynegative regulation of growth hormone receptor signaling pathwaynegative regulation of hippo signaling cascadenegative regulation of hypoxia-inducible factor-1alpha signaling pathwaynegative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activitynegative regulation of insulin receptor signaling pathway +negative regulation of insulin-like growth factor receptor signaling pathwaynegative regulation of integrin-mediated signaling pathwaynegative regulation of intracellular protein kinase cascade +negative regulation of intracellular steroid hormone receptor signaling pathway +negative regulation of lipopolysaccharide-mediated signaling pathway +negative regulation of nerve growth factor receptor activitynegative regulation of neurotrophin TRK receptor signaling pathwaynegative regulation of NIK/NF-kappaB cascadenegative regulation of nitric oxide mediated signal transductionnegative regulation of Notch signaling pathwaynegative regulation of nucleotide-binding oligomerization domain containing signaling pathway +negative regulation of peptidoglycan recognition protein signaling pathwaynegative regulation of peroxisome proliferator activated receptor signaling pathwaynegative regulation of phosphatidylinositol 3-kinase cascadenegative regulation of phosphorelay signal transduction system +negative regulation of platelet-derived growth factor receptor signaling pathway +negative regulation of red or far-red light signaling pathwaynegative regulation of retinoic acid receptor signaling pathwaynegative regulation of Roundabout signaling pathway +negative regulation of semaphorin-plexin signaling pathwaynegative regulation of sevenless signaling pathwaynegative regulation of signal transduction by p53 class mediator +negative regulation of signal transduction by receptor internalization +negative regulation of signal transduction in absence of ligand +negative regulation of signal transduction in response to host +negative regulation of signal transduction involved in conjugation with cellular fusion +negative regulation of small GTPase mediated signal transduction +negative regulation of smoothened signaling pathway +negative regulation of sphingolipid mediated signaling pathwaynegative regulation of SREBP signaling pathway +negative regulation of thyroid hormone mediated signaling pathwaynegative regulation of Toll signaling pathwaynegative regulation of toll-like receptor signaling pathway +negative regulation of TOR signaling cascadenegative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway +negative regulation of vascular endothelial growth factor receptor signaling pathwaynegative regulation of vascular endothelial growth factor signaling pathwaynegative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway +negative regulation of vitamin D receptor signaling pathwaynegative regulation of Wnt receptor signaling pathway +termination of signal transduction +biological_processcellular processregulation of cellular processregulation of cell communicationregulation of signal transductionregulation of G-protein coupled receptor protein signaling pathwaycross-receptor inhibition within G-protein coupled receptor heterodimermodulation by host of symbiont G-protein coupled receptor protein signal transduction +modulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of G-protein coupled receptor protein signaling pathway [GO:0045744] (58 genes, 78 annotations)desensitization of G-protein coupled receptor protein signaling pathway +negative regulation by host of symbiont G-protein coupled receptor protein signal transduction +negative regulation by symbiont of host G-protein coupled receptor protein signal transduction +negative regulation of adenosine receptor signaling pathwaynegative regulation of adrenergic receptor signaling pathway +negative regulation of dopamine receptor signaling pathway +negative regulation of G-protein coupled receptor protein signaling pathway in response to host +negative regulation of octopamine or tyramine signaling pathway +negative regulation of opioid receptor signaling pathway +negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusionnegative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway +
Analysis Tools