Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes METAP2
  • Mouse genes Metap2
  • Rat genes Metap2
  • Zfish genes metap2a,metap2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Metap2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004177	aminopeptidase activity	METAP2	IDA		Human	PMID:8858118
Molecular Function	GO:0008235	metalloexopeptidase activity	METAP2	IDA		Human	PMID:8858118
Molecular Function	GO:0005515	protein binding	METAP2	IPI	UniProtKB:P21917	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Metap2	IPI	PR:P63085	Mouse	PMID:15544353
Molecular Function	GO:0005515	protein binding	Metap2	IPI	PR:Q6ZWX6	Mouse	PMID:15544353
Molecular Function	GO:0005515	protein binding	Metap2	IPI	PR:Q63844	Mouse	PMID:15544353
Molecular Function	GO:0003723	RNA binding	METAP2	HDA		Human	PMID:22658674
Cellular Component	GO:0005737	cytoplasm	METAP2	IDA		Human	PMID:15102683
Cellular Component	GO:0005829	cytosol	METAP2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	METAP2	IDA		Human	GO_REF:0000052
Biological Process	GO:0060216	definitive hemopoiesis	metap2b	IMP	ZFIN:ZDB-MRPHLNO-061013-1	Zfish	PMID:21937698
Biological Process	GO:0060218	hematopoietic stem cell differentiation	metap2b	IMP	ZFIN:ZDB-MRPHLNO-061013-1	Zfish	PMID:21937698
Biological Process	GO:0031365	N-terminal protein amino acid modification	METAP2	IDA		Human	PMID:8858118
Biological Process	GO:0018206	peptidyl-methionine modification	METAP2	IDA		Human	PMID:8858118
Biological Process	GO:0016485	protein processing	METAP2	IDA		Human	PMID:8858118
Biological Process	GO:0016055	Wnt signaling pathway	metap2b	IGI	ZFIN:ZDB-MRPHLNO-041217-11,ZFIN:ZDB-MRPHLNO-061013-1	Zfish	PMID:16984890
Biological Process	GO:0016055	Wnt signaling pathway	metap2b	IMP	ZFIN:ZDB-MRPHLNO-061013-1	Zfish	PMID:16984890

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern