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Metap2 Gene Detail
Summary
  • Symbol
    Metap2
  • Name
    methionine aminopeptidase 2
  • Synonyms
    4930584B20Rik, A930035J23Rik, eIF-2-associated p67, p67
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929701
    NCBI Gene: 56307
  • Gene Overview
    MyGene.info: METAP2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:93858489-93897093 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38605 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 48.69 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    METAP2, methionyl aminopeptidase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    METAP2, methionyl aminopeptidase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAP2, MNPEP, p67eIF2
  • Links
    NCBI Gene ID: 10988
    neXtProt AC: NX_P50579
    UniProt: P50579

  • Chr Location
    12q22; chr12:95474046-95515839 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality around E8.5, smaller size, failure to gastrulate, reduced cell proliferation and absence of a distinct mesoderm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000042658 VEGA Gene Model | MGI Sequence Detail 38605 C57BL/6J ±  kb
    transcript OTTMUST00000112332 VEGA | MGI Sequence Detail 1984 Not Applicable  
    polypeptide OTTMUSP00000063066 VEGA | MGI Sequence Detail 488 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      492 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • EC
    • InterPro Domains
      IPR036005 Creatinase/aminopeptidase-like
      IPR000994 Peptidase M24
      IPR002468 Peptidase M24A, methionine aminopeptidase, subfamily 2
      IPR018349 Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site
      IPR001714 Peptidase M24, methionine aminopeptidase
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 24
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1923115, MGI:1925609, MGI:2143717, MGI:2144066, MGI:2144355
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory