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Metap2
Gene Detail
Symbol

Name
ID
Metap2
methionine aminopeptidase 2
MGI:1929701
Synonyms
4930584B20Rik, A930035J23Rik, eIF-2-associated p67, p67
Feature Type
protein coding gene
Genetic Map
Chromosome 10
48.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:93858489-93897093 bp, - strand
From VEGA annotation of GRCm38

  38605 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4981  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: METAP2
Protein SuperFamily: methionyl aminopeptidase
Gene Tree: Metap2

Human
homologs
METAP2, methionyl aminopeptidase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10988
neXtProt AC: NX_P50579

Human Synonyms: MAP2, MNPEP, p67, p67eIF2

Human Chr (Location): 12q22; chr12:95474046-95515839 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(13) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in embryonic lethality around E8.5, smaller size, failure to gastrulate, reduced cell proliferation and absence of a distinct mesoderm.
 
Interactions
Metap2 interacts with 308 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process N-terminal protein amino acid modification, peptidyl-methionine modification, ...
Component cytoplasm, plasma membrane
Function aminopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (6)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA METAP2 ; Xenbase metap2 ; ZFIN metap2a, metap2b    NEW 
Molecular
reagents
All nucleic(23) cDNA(22) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000042658 (Evidence)
Ensembl Gene Model ENSMUSG00000036112 (Evidence)
Entrez Gene 56307 (Evidence)
EC 3.4.11.18
Consensus CDS Project CCDS48673.1
International Mouse Phenotyping Consortium Status Metap2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042658 VEGA Gene Model | MGI Sequence Detail 38605 C57BL/6J ±  kb
transcript OTTMUST00000112332 VEGA | MGI Sequence Detail 1984 Not Applicable 
polypeptide OTTMUSP00000063066 VEGA | MGI Sequence Detail 488 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(8) UniProt(9)
Polymorphisms
SNPs within 2kb(511 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002468 Peptidase M24A, methionine aminopeptidase, subfamily 2
InterPro IPR018349 Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site
InterPro IPR001714 Peptidase M24, methionine aminopeptidase
InterPro IPR000994 Peptidase M24, structural domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000010337 methionine aminopeptidase 2
References
(Earliest) J:66299 Wu S, et al., Cloning and characterization of complementary DNA encoding the eukaryotic initiation factor 2-associated 67-kDa protein (p67). J Biol Chem. 1993 May 25;268(15):10796-81
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(38)
Other
accession IDs
MGI:1923115, MGI:1925609, MGI:2143717, MGI:2144066, MGI:2144355

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory