Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Map2k7

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MAP2K7
- Mouse genes Map2k7
- Rat genes Map2k7
- Zfish genes map2k7
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map2k7

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Map2k7	IDA		Rat	PMID:10051439\|RGD:2298561
Molecular Function	GO:0019899	enzyme binding	MAP2K7	IPI	UniProtKB:P12821	Human	PMID:14615289
Molecular Function	GO:0008545	JUN kinase kinase activity	Map2k7	IDA		Mouse	MGI:MGI:2182169\|PMID:11959862
Molecular Function	GO:0008545	JUN kinase kinase activity	Map2k7	IDA		Mouse	MGI:MGI:1101248\|PMID:9405446
Molecular Function	GO:0008545	JUN kinase kinase activity	Map2k7	IDA		Rat	PMID:10051439\|RGD:2298561
Molecular Function	GO:0008545	JUN kinase kinase activity	Map2k7	IDA		Rat	PMID:11849756\|RGD:2298565
Molecular Function	GO:0008545	JUN kinase kinase activity	Map2k7	IDA		Rat	PMID:17064355\|RGD:2298577
Molecular Function	GO:0000287	magnesium ion binding	MAP2K7	IDA		Human	PMID:9535930
Molecular Function	GO:0000287	magnesium ion binding	Map2k7	IDA		Mouse	MGI:MGI:1101248\|PMID:9405446
Molecular Function	GO:0000287	magnesium ion binding	Map2k7	IDA		Rat	PMID:10051439\|RGD:2298561
Molecular Function	GO:0004707	MAP kinase activity	Map2k7	IDA		Mouse	MGI:MGI:1101248\|PMID:9405446
Molecular Function	GO:0004708	MAP kinase kinase activity	MAP2K7	IDA		Human	PMID:9535930
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k7	IDA		Rat	PMID:10051439\|RGD:2298561
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k7	IDA		Rat	PMID:20550965\|RGD:7243113
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	Map2k7	IPI	RGD:1306431	Rat	PMID:14575811\|RGD:2298566
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	Map2k7	IPI	RGD:1359261	Rat	PMID:14575811\|RGD:2298566
Molecular Function	GO:0031435	mitogen-activated protein kinase kinase kinase binding	Map2k7	IPI	RGD:620966	Rat	PMID:16006144\|RGD:2293486
Molecular Function	GO:0140677	molecular function activator activity	MAP2K7	EXP		Human	PMID:25737554
Molecular Function	GO:0005515	protein binding	MAP2K7	IPI	UniProtKB:Q96RU7	Human	PMID:15299019
Molecular Function	GO:0005515	protein binding	MAP2K7	IPI	UniProtKB:Q9UQF2	Human	PMID:16840345
Molecular Function	GO:0005515	protein binding	MAP2K7	IPI	UniProtKB:O15519-1	Human	PMID:17110930
Molecular Function	GO:0005515	protein binding	MAP2K7	IPI	UniProtKB:O43318	Human	PMID:17110930
Molecular Function	GO:0005515	protein binding	MAP2K7	IPI	UniProtKB:O43318	Human	PMID:17709393
Molecular Function	GO:0005515	protein binding	MAP2K7	IPI	UniProtKB:Q9UQF2	Human	PMID:18286207
Molecular Function	GO:0005515	protein binding	MAP2K7	IPI	UniProtKB:Q5S007	Human	PMID:20067578
Molecular Function	GO:0005515	protein binding	MAP2K7	IPI	UniProtKB:P08238	Human	PMID:22939624
Molecular Function	GO:0005515	protein binding	MAP2K7	IPI	UniProtKB:O43318	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	MAP2K7	IPI	UniProtKB:O75293	Human	PMID:25314077
Molecular Function	GO:0005515	protein binding	MAP2K7	IPI	UniProtKB:P08238	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Map2k7	IPI	PR:Q9ESN9	Mouse	PMID:15767678
Molecular Function	GO:0005515	protein binding	Map2k7	IPI	PR:Q8K4T5	Mouse	PMID:11959861
Molecular Function	GO:0005515	protein binding	Map2k7	IPI	PR:O35099	Mouse	PMID:11959862
Molecular Function	GO:0005515	protein binding	Map2k7	IPI	RGD:70937	Rat	PMID:15816852\|RGD:1579811
Molecular Function	GO:0005515	protein binding	Map2k7	IPI	RGD:70937	Rat	PMID:17348686\|RGD:2298766
Molecular Function	GO:0019901	protein kinase binding	MAP2K7	IPI	UniProtKB:Q12852	Human	PMID:14697235
Molecular Function	GO:0019903	protein phosphatase binding	Map2k7	IPI	UniProtKB:Q8K4T5	Mouse	MGI:MGI:2182169\|PMID:11959862
Cellular Component	GO:0005737	cytoplasm	Map2k7	IDA		Mouse	MGI:MGI:1328676\|PMID:9891090
Cellular Component	GO:0005829	cytosol	Map2k7	IDA		Rat	PMID:15816852\|RGD:1579811
Cellular Component	GO:0005634	nucleus	Map2k7	IDA		Mouse	MGI:MGI:1328676\|PMID:9891090
Cellular Component	GO:0005634	nucleus	Map2k7	IDA		Rat	PMID:15816852\|RGD:1579811
Biological Process	GO:0071347	cellular response to interleukin-1	Map2k7	IMP		Mouse	MGI:MGI:1101248\|PMID:9405446
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Map2k7	IMP		Mouse	MGI:MGI:1101248\|PMID:9405446
Biological Process	GO:0071470	cellular response to osmotic stress	Map2k7	IDA		Rat	PMID:10051439\|RGD:2298561
Biological Process	GO:0072709	cellular response to sorbitol	Map2k7	IEP		Rat	PMID:20550965\|RGD:7243113
Biological Process	GO:0007254	JNK cascade	Map2k7	IDA		Mouse	MGI:MGI:2182169\|PMID:11959862
Biological Process	GO:0007254	JNK cascade	Map2k7	IDA		Rat	PMID:10051439\|RGD:2298561
Biological Process	GO:0007254	JNK cascade	Map2k7	IDA		Rat	PMID:11849756\|RGD:2298565
Biological Process	GO:0007254	JNK cascade	Map2k7	IDA		Rat	PMID:15680699\|RGD:2298567
Biological Process	GO:0007254	JNK cascade	Map2k7	IDA		Rat	PMID:17064355\|RGD:2298577
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MAP2K7	IMP		Human	PMID:28111074
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MAP2K7	IMP		Human	PMID:28111074
Biological Process	GO:0046330	positive regulation of JNK cascade	Map2k7	IDA		Mouse	MGI:MGI:1101248\|PMID:9405446
Biological Process	GO:0046330	positive regulation of JNK cascade	Map2k7	IDA		Rat	PMID:10051439\|RGD:2298561
Biological Process	GO:0046330	positive regulation of JNK cascade	Map2k7	IDA		Rat	PMID:11849756\|RGD:2298565
Biological Process	GO:0046330	positive regulation of JNK cascade	Map2k7	IDA		Rat	PMID:17064355\|RGD:2298577
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Map2k7	IDA		Mouse	MGI:MGI:2182169\|PMID:11959862
Biological Process	GO:0043525	positive regulation of neuron apoptotic process	Map2k7	IMP		Rat	PMID:12514131\|RGD:2293340
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Map2k7	IDA		Rat	PMID:20550965\|RGD:7243113
Biological Process	GO:0051973	positive regulation of telomerase activity	MAP2K7	IMP		Human	PMID:21531765
Biological Process	GO:1904355	positive regulation of telomere capping	MAP2K7	IMP		Human	PMID:21531765
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	MAP2K7	IMP		Human	PMID:21531765
Biological Process	GO:0006468	protein phosphorylation	Map2k7	IDA		Rat	PMID:10051439\|RGD:2298561
Biological Process	GO:0006468	protein phosphorylation	Map2k7	IDA		Rat	PMID:17064355\|RGD:2298577
Biological Process	GO:2000671	regulation of motor neuron apoptotic process	Map2k7	IMP	MGI:MGI:4948950	Mouse	PMID:25100604
Biological Process	GO:0009408	response to heat	MAP2K7	IDA		Human	PMID:9535930
Biological Process	GO:0006970	response to osmotic stress	MAP2K7	IDA		Human	PMID:9535930
Biological Process	GO:0006970	response to osmotic stress	Map2k7	IDA		Rat	PMID:10051439\|RGD:2298561
Biological Process	GO:0034612	response to tumor necrosis factor	MAP2K7	IDA		Human	PMID:9535930
Biological Process	GO:0009411	response to UV	MAP2K7	IDA		Human	PMID:9535930
Biological Process	GO:0009611	response to wounding	Map2k7	IMP	MGI:MGI:4948950	Mouse	PMID:25100604
Biological Process	GO:0001756	somitogenesis	map2k7	IMP	ZFIN:ZDB-MRPHLNO-110314-3	Zfish	PMID:20564202
Biological Process	GO:0051403	stress-activated MAPK cascade	MAP2K7	IDA		Human	PMID:9535930
Biological Process	GO:0051403	stress-activated MAPK cascade	Map2k7	IDA		Rat	PMID:10051439\|RGD:2298561

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.