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Map2k7 Gene Detail
Summary
  • Symbol
    Map2k7
  • Name
    mitogen-activated protein kinase kinase 7
  • Synonyms
    5930412N11Rik, Jnkk2, MAP kinase kinase 7, MKK7, Prkmk7, sek2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346871
    NCBI Gene: 26400
  • Gene Overview
    MyGene.info: MAP2K7
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 8, 1.99 cM, cytoband A1.1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MAP2K7, mitogen-activated protein kinase kinase 7
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAP2K7, mitogen-activated protein kinase kinase 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK4, SAPKK-4
  • Links
    NCBI Gene ID: 5609
    neXtProt AC: NX_O14733
    UniProt: O14733

  • Chr Location
    19p13.2; chr19:7903780-7914483 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Map2k7 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 8 alleles in 9 genetic backgrounds
    13 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die during embryogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000059344 VEGA Gene Model | MGI Sequence Detail 9158 C57BL/6J ±  kb
    transcript OTTMUST00000039738 VEGA | MGI Sequence Detail 1626 Not Applicable  
    polypeptide OTTMUSP00000017733 VEGA | MGI Sequence Detail 468 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      73 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 24
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1099437, MGI:2443684
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 13
      Diseases 1
      Gene Ontology 7
      Phenotypes 28
    • Earliest
      J:41744 Tournier C, et al., Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7337-42
    • Latest
      J:261382 Kant S, et al., A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress. Cell Rep. 2017 Sep 19;20(12):2775-2783

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory