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Map2k7
Gene Detail
Symbol

Name
ID
Map2k7
mitogen-activated protein kinase kinase 7
MGI:1346871
Synonyms
5930412N11Rik, Jnkk2, MAP kinase kinase 7, MKK7, Prkmk7, sek2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
1.99 cM, cytoband A1.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:4238740-4251423 bp, + strand
From VEGA annotation of GRCm38

  12684 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56548  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Map2k7

Human
homologs
Human Homolog MAP2K7, mitogen-activated protein kinase kinase 7
NCBI Gene ID 5609
neXtProt AC  NX_O14733
Human Synonyms  JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK4, SAPKK-4
Human Chr (Location)  19p13.3-p13.2; chr19:7903780-7914478 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(9)
 
Mice homozygous for disruptions in this gene die during embryogenesis.
 
Human Diseases Modeled Using Mouse Map2k7 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Map2k7 interacts with 261 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process activation of JUN kinase activity, apoptotic process, ...
Component cytoplasm, cytosol, ...
Function ATP binding, JUN kinase kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (38)    Tissues (27)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 27
Northern blot 8
Western blot 3
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(23) Other(1)
Microarray probesets(7)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020569 VEGA Gene Model | MGI Sequence Detail 12684 C57BL/6J ±  kb
transcript OTTMUST00000039740 VEGA | MGI Sequence Detail 2879 Not Applicable 
polypeptide OTTMUSP00000045502 VEGA | MGI Sequence Detail 535 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(90 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000010128 dual specificity mitogen-activated protein kinase kinase 7
References
(Earliest) J:41744 Tournier C, et al., Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7337-42
(Latest) J:212458 Davies CC, et al., Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma. Cancer Res. 2014 Jun 15;74(12):3344-56
All references(61)
Disease annotation references (1)
Other
accession IDs
MGI:1099437, MGI:2443684

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory