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Map2k7 Gene Detail
Summary
  • Symbol
    Map2k7
  • Name
    mitogen-activated protein kinase kinase 7
  • Synonyms
    5930412N11Rik, Jnkk2, MAP kinase kinase 7, MKK7, Prkmk7, sek2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346871
    NCBI Gene: 26400
  • Gene Overview
    MyGene.info: MAP2K7
Location & Maps
more
  • Genetic Map
    Chromosome 8, 1.99 cM, cytoband A1.1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MAP2K7, mitogen-activated protein kinase kinase 7
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAP2K7, mitogen-activated protein kinase kinase 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK4, SAPKK-4
  • Links
    NCBI Gene ID: 5609
    neXtProt AC: NX_O14733

  • Chr Location
    19p13.3-p13.2; chr19:7903780-7914483 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Map2k7 mouse models

Human Disease Mouse Models
       Schizophrenia; SCZD   OMIM: 181500 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 8 alleles in 9 genetic backgrounds
    13 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Gene trapped
    1
  • Targeted
    10
  • Transgenic
    1
Mice homozygous for disruptions in this gene die during embryogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26400 NCBI Gene Model | MGI Sequence Detail 9158 C57BL/6J ±  kb
transcript NM_001164172 RefSeq | MGI Sequence Detail 3556 C57BL/6  
polypeptide Q8CE90 UniProt | EBI | MGI Sequence Detail 535 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    73 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010128 dual specificity mitogen-activated protein kinase kinase 7
  • EC
  • InterPro Domains
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 24
    cDNA 23
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1099437, MGI:2443684
References
more
  • Summaries
    All 61
    Developmental Gene Expression 12
    Diseases 1
    Gene Ontology 11
    Phenotypes 22
  • Earliest
    J:41744 Tournier C, et al., Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7337-42
  • Latest
    J:215576 Itoh T, et al., ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. J Neurosci. 2014 Aug 6;34(32):10729-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory