Map2k7
Gene Detail

Symbol Name ID

Map2k7 mitogen-activated protein kinase kinase 7 MGI:1346871

Synonyms

5930412N11Rik, Jnkk2, MAP kinase kinase 7, MKK7, Prkmk7, sek2

Feature Type

protein coding gene

Genetic Map

Chromosome 8

1.99 cM, cytoband A1.1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr8:4238740-4251423 bp, + strand From VEGA annotation of GRCm38   12684 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56548  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Map2k7

Human homologs

Human Homolog		MAP2K7, mitogen-activated protein kinase kinase 7
NCBI Gene ID		5609
neXtProt AC		NX_O14733
Human Synonyms		Jnkk2, MAPKK7, MKK7, PRKMK7, SAPKK4, SAPKK-4
Human Chr (Location)		19p13.3-p13.2; chr19:7968765-7979363 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(9) Gene trapped(1)
 

Mice homozygous for disruptions in this gene die during embryogenesis.

 
Human Diseases Modeled Using Mouse Map2k7 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	activation of JUN kinase activity, apoptotic process, ...
Component	cytoplasm, cytosol, ...
Function	ATP binding, JUN kinase kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (38)    Tissues (27)    Images (6)
Theiler Stages: 20, 22, 23, 26, 28

Assay Type	Results
RNA in situ	27
Northern blot	8
Western blot	3

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(23) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000020569 (Evidence)
Ensembl Gene Model	ENSMUSG00000002948 (Evidence)
Entrez Gene	26400 (Evidence)
DFCI	TC1578114, TC1591120, TC1595684, TC1596425, TC1598998, TC1599765
DoTS	DT.101377714, DT.101377715, DT.101377716, DT.101377719, DT.101735702, DT.110886410, DT.55199883, DT.91341752, DT.94250243, DT.94331622
EC	2.7.12.2
Consensus CDS Project	CCDS40208.1, CCDS40209.1, CCDS52474.1
International Mouse Knockout Project Status	Map2k7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020569	VEGA Gene Model | MGI Sequence Detail	12684	C57BL/6J
transcript	OTTMUST00000039740	VEGA | MGI Sequence Detail	2879	Not Applicable
polypeptide	OTTMUSP00000045502	VEGA | MGI Sequence Detail	535	Not Applicable

All sequences(95) RefSeq(6) UniProt(1)

Polymorphisms

SNPs(62 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000010128	dual specificity mitogen-activated protein kinase kinase 7

References

(Earliest) J:41744 Tournier C, et al., Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7337-42
(Latest) J:188339 Winchester CL, et al., Converging evidence that sequence variations in the novel candidate gene MAP2K7 (MKK7) are functionally associated with schizophrenia. Hum Mol Genet. 2012 Nov 15;21(22):4910-21
All references(57)

Other accession IDs

MGI:1099437, MGI:2443684