Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAP2K3
  • Mouse genes Map2k3
  • Rat genes Map2k3
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Map2k3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004708	MAP kinase kinase activity	MAP2K3	IDA		Human	PMID:8622669
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k3	IMP	MGI:MGI:1857752	Mouse	PMID:10097111
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k3	IDA		Mouse	PMID:10202148
Molecular Function	GO:0004708	MAP kinase kinase activity	Map2k3	IDA		Mouse	PMID:8900184
Molecular Function	GO:0005515	protein binding	MAP2K3	IPI	UniProtKB:Q9Y463	Human	PMID:11980910
Molecular Function	GO:0005515	protein binding	MAP2K3	IPI	UniProtKB:Q16539	Human	PMID:17255949
Molecular Function	GO:0005515	protein binding	MAP2K3	IPI	UniProtKB:Q99683	Human	PMID:19805025
Molecular Function	GO:0005515	protein binding	MAP2K3	IPI	UniProtKB:Q5S007	Human	PMID:20067578
Molecular Function	GO:0005515	protein binding	MAP2K3	IPI	UniProtKB:Q5S007	Human	PMID:20173330
Molecular Function	GO:0005515	protein binding	MAP2K3	IPI	UniProtKB:Q9BSI4	Human	PMID:21044950
Molecular Function	GO:0005515	protein binding	MAP2K3	IPI	UniProtKB:Q99683	Human	PMID:21771788
Molecular Function	GO:0005515	protein binding	MAP2K3	IPI	UniProtKB:Q16539	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	MAP2K3	IPI	UniProtKB:Q16539	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAP2K3	IPI	UniProtKB:Q99683	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAP2K3	IPI	UniProtKB:Q16539	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	Map2k3	IPI	UniProtKB:Q61249	Mouse	MGI:MGI:4457251|PMID:17438131
Molecular Function	GO:0005515	protein binding	Map2k3	IPI	RGD:620106	Rat	PMID:23658158|RGD:7257606
Molecular Function	GO:0019901	protein kinase binding	MAP2K3	IPI	UniProtKB:Q9UL54	Human	PMID:11279118
Molecular Function	GO:0019901	protein kinase binding	Map2k3	IPI	UniProtKB:O35099	Mouse	MGI:MGI:3829088|PMID:18948261
Cellular Component	GO:0005829	cytosol	Map2k3	IDA		Rat	PMID:9779826|RGD:70317
Cellular Component	GO:0016020	membrane	MAP2K3	HDA		Human	PMID:19946888
Biological Process	GO:0060048	cardiac muscle contraction	Map2k3	IMP	MGI:MGI:2385922,MGI:MGI:3581033	Mouse	PMID:11593045
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Map2k3	IDA		Rat	PMID:14670949|RGD:7495812
Biological Process	GO:0072709	cellular response to sorbitol	Map2k3	IEP		Rat	PMID:20550965|RGD:7243113
Biological Process	GO:0035924	cellular response to vascular endothelial growth factor stimulus	MAP2K3	IMP		Human	PMID:22696064
Biological Process	GO:0007507	heart development	Map2k3	IEP		Rat	PMID:9779826|RGD:70317
Biological Process	GO:0006954	inflammatory response	Map2k3	IMP	MGI:MGI:1857752	Mouse	PMID:10202148
Biological Process	GO:0006954	inflammatory response	Map2k3	IMP	MGI:MGI:1857752	Mouse	PMID:10097111
Biological Process	GO:0000165	MAPK cascade	Map2k3	IMP	MGI:MGI:1857752	Mouse	PMID:10097111
Biological Process	GO:0000165	MAPK cascade	Map2k3	IDA		Mouse	PMID:8900184
Biological Process	GO:0035331	negative regulation of hippo signaling	MAP2K3	IMP		Human	PMID:27402810
Biological Process	GO:0038066	p38MAPK cascade	MAP2K3	IMP		Human	PMID:22696064
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	MAP2K3	IMP		Human	PMID:22696064
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	MAP2K3	IDA		Human	PMID:11980910
Biological Process	GO:0043410	positive regulation of MAPK cascade	Map2k3	IGI	MGI:MGI:1918084	Mouse	PMID:15767678
Biological Process	GO:0043410	positive regulation of MAPK cascade	Map2k3	IDA		Mouse	PMID:15767678
Biological Process	GO:0043410	positive regulation of MAPK cascade	Map2k3	IGI	MGI:MGI:1346870	Mouse	PMID:15767678
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Map2k3	IMP		Rat	PMID:10593906|RGD:2304240
Biological Process	GO:0045860	positive regulation of protein kinase activity	MAP2K3	IDA		Human	PMID:11980910
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Map2k3	IDA		Rat	PMID:20550965|RGD:7243113
Biological Process	GO:0001817	regulation of cytokine production	Map2k3	IMP	MGI:MGI:1857752	Mouse	PMID:10097111
Biological Process	GO:0002931	response to ischemia	Map2k3	IEP		Rat	PMID:20550965|RGD:7243113
Biological Process	GO:0031098	stress-activated protein kinase signaling cascade	MAP2K3	IDA		Human	PMID:8622669

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern