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Map2k3
Gene Detail
 Symbol
Name
ID
Map2k3
mitogen-activated protein kinase kinase 3
MGI:1346868
Synonyms MAP kinase kinase 3, MKK3, Prkmk3
Feature Type protein coding gene
Genetic Map
Chromosome 11
37.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:60932033-60952811 bp, + strand
From VEGA annotation of GRCm38

  20779 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Map2k3

Human
homologs
Human Homolog MAP2K3, mitogen-activated protein kinase kinase 3
NCBI Gene ID 5606
neXtProt AC  NX_P46734
Human Synonyms  MAPKK3, MEK3, MKK3, PRKMK3, SAPKK2, SAPKK-2
Human Chr (Location)  17q11.2; chr17:21284656-21315240 (+)  GRCh38
Alleles
and
phenotypes
All alleles(14) : Targeted(5) Gene trapped(9)
 
Mice homozygous for disruptions in this gene are viable and fertile but display abnormalities in cytokine production.
 
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process activation of MAPK activity, cardiac muscle contraction, ...
Component cytoplasm, cytosol, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (118)    Tissues (109)    Images (15)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 118
cDNA source data(160)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(161) cDNA(160) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000006341 (Evidence)
Ensembl Gene ModelENSMUSG00000018932 (Evidence)
Entrez Gene26397 (Evidence)
UniGene18494
DFCITC1572340, TC1595416, TC1596538, TC1744394
DoTSDT.101397127, DT.495356, DT.91438278, DT.99862653
NIA Mouse Gene IndexU012710
EC2.7.12.2
PDB1LEZ
Consensus CDS ProjectCCDS24804.1
International Mouse Knockout Project StatusMap2k3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006341 VEGA Gene Model | MGI Sequence Detail 20779 C57BL/6J ±  kb
transcript OTTMUST00000014413 VEGA | MGI Sequence Detail 2198 Not Applicable 
polypeptide OTTMUSP00000006687 VEGA | MGI Sequence Detail 347 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(6) UniProt(6)
Polymorphisms SNPs within 2kb(181 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003284 dual specificity mitogen-activated protein kinase kinase 3
References (Earliest) J:51747 Moriguchi T, et al., Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2. J Biol Chem. 1996 Oct 25;271(43):26981-8
(Latest) J:205361 Kang Y, et al., MAPK kinase 3 potentiates Chlamydia HSP60-induced inflammatory response through distinct activation of NF-kappaB. J Immunol. 2013 Jul 1;191(1):386-94
All references(87)
Other
accession IDs
MGI:1328353, MGI:2144511

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory