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Map2k3 Gene Detail
Summary
  • Symbol
    Map2k3
  • Name
    mitogen-activated protein kinase kinase 3
  • Synonyms
    MAP kinase kinase 3, MKK3, Prkmk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346868
    NCBI Gene: 26397
  • Gene Overview
    MyGene.info: MAP2K3
Location & Maps
more
  • Sequence Map
    Chr11:60932033-60952811 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20779 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.95 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MAP2K3, mitogen-activated protein kinase kinase 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MAP2K3, mitogen-activated protein kinase kinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAPKK3, MEK3, MKK3, PRKMK3, SAPKK2, SAPKK-2
  • Links
    NCBI Gene ID: 5606
    neXtProt AC: NX_P46734

  • Chr Location
    17q11.2; chr17:21284656-21315240 (+)  GRCh38.p2

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    1
  • Gene trapped
    9
  • Targeted
    7
  • Transgenic
    2
  • Genomic Mutations
    3 involving Map2k3
  • Incidental Mutations
    APF
Mice homozygous for disruptions in this gene are viable and fertile but display abnormalities in cytokine production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006341 VEGA Gene Model | MGI Sequence Detail 20779 C57BL/6J ±  kb
transcript OTTMUST00000014413 VEGA | MGI Sequence Detail 2198 Not Applicable  
polypeptide OTTMUSP00000006687 VEGA | MGI Sequence Detail 347 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    184 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000003284 dual specificity mitogen-activated protein kinase kinase 3
  • PDB
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 162
    cDNA 160
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
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MGI:1328353, MGI:2144511
References
more
  • Summaries
    All 91
    Developmental Gene Expression 6
    Diseases 2
    Gene Ontology 12
    Phenotypes 65
  • Earliest
    J:51747 Moriguchi T, et al., Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2. J Biol Chem. 1996 Oct 25;271(43):26981-8
  • Latest
    J:218387 Greenblatt MB, et al., p38alpha MAPK is required for tooth morphogenesis and enamel secretion. J Biol Chem. 2015 Jan 2;290(1):284-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory