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Map2k3
Gene Detail
Symbol

Name
ID
Map2k3
mitogen-activated protein kinase kinase 3
MGI:1346868
Synonyms
MAP kinase kinase 3, MKK3, Prkmk3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:60932033-60952811 bp, + strand
From VEGA annotation of GRCm38

  20779 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56430  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: MAP2K3
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Map2k3

Human
homologs
MAP2K3, mitogen-activated protein kinase kinase 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5606
neXtProt AC: NX_P46734

Human Synonyms: MAPKK3, MEK3, MKK3, PRKMK3, SAPKK2, SAPKK-2

Human Chr (Location): 17q11.2; chr17:21284656-21315240 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(9) Targeted(7) Transgenic(1)
Genomic Mutations involving Map2k3 (2)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene are viable and fertile but display abnormalities in cytokine production.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Map2k3 interacts with 202 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process activation of MAPK activity, cardiac muscle contraction, ...
Component cytoplasm, cytosol, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (131)    Tissues (122)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 118
RT-PCR 7
cDNA source data(160)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(162) cDNA(160) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000006341 (Evidence)
Ensembl Gene Model ENSMUSG00000018932 (Evidence)
Entrez Gene 26397 (Evidence)
UniGene 18494
DFCI TC1744394, TC1596538, TC1595416, TC1572340
DoTS DT.91438278, DT.495356, DT.101397127, DT.99862653
NIA Mouse Gene Index U012710
EC 2.7.12.2
PDB 1LEZ
Consensus CDS Project CCDS24804.1
International Mouse Phenotyping Consortium Status Map2k3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006341 VEGA Gene Model | MGI Sequence Detail 20779 C57BL/6J ±  kb
transcript OTTMUST00000014413 VEGA | MGI Sequence Detail 2198 Not Applicable 
polypeptide OTTMUSP00000006687 VEGA | MGI Sequence Detail 347 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(181 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003284 dual specificity mitogen-activated protein kinase kinase 3
References
(Earliest) J:51747 Moriguchi T, et al., Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2. J Biol Chem. 1996 Oct 25;271(43):26981-8
(Latest) J:218387 Greenblatt MB, et al., p38alpha MAPK is required for tooth morphogenesis and enamel secretion. J Biol Chem. 2015 Jan 2;290(1):284-95
All references(92)
Other
accession IDs
MGI:1328353, MGI:2144511

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory