Map2k3
Gene Detail

Symbol Name ID

Map2k3 mitogen-activated protein kinase kinase 3 MGI:1346868

Synonyms

MAP kinase kinase 3, MKK3, Prkmk3

Feature Type

protein coding gene

Genetic Map

Chromosome 11

37.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:60932033-60952811 bp, + strand From VEGA annotation of GRCm38   20779 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Map2k3

Human homologs

Human Homolog		MAP2K3, mitogen-activated protein kinase kinase 3
NCBI Gene ID		5606
neXtProt AC		NX_P46734
Human Synonyms		MAPKK3, MEK3, MKK3, PRKMK3, SAPKK2, SAPKK-2
Human Chr (Location)		17q11.2; chr17:21187968-21218552 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(14) : Targeted(5) Gene trapped(9)
 

Mice homozygous for disruptions in this gene are viable and fertile but display abnormalities in cytokine production.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	activation of MAPK activity, cardiac muscle contraction, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (118)    Tissues (109)    Images (15)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	118

cDNA source data(162)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(163) cDNA(162) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000006341 (Evidence)
Ensembl Gene Model	ENSMUSG00000018932 (Evidence)
Entrez Gene	26397 (Evidence)
UniGene	18494
DFCI	TC1572340, TC1595416, TC1596538, TC1744394
DoTS	DT.101397127, DT.495356, DT.91438278, DT.99862653
NIA Mouse Gene Index	U012710
EC	2.7.12.2
PDB	1LEZ
Consensus CDS Project	CCDS24804.1
International Mouse Knockout Project Status	Map2k3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006341	VEGA Gene Model | MGI Sequence Detail	20779	C57BL/6J
transcript	OTTMUST00000014413	VEGA | MGI Sequence Detail	2198	Not Applicable
polypeptide	OTTMUSP00000006687	VEGA | MGI Sequence Detail	347	Not Applicable

All sequences(59) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(115 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000003284	dual specificity mitogen-activated protein kinase kinase 3

References

(Earliest) J:51747 Moriguchi T, et al., Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2. J Biol Chem. 1996 Oct 25;271(43):26981-8
(Latest) J:194180 Gonzalez-Teran B, et al., Eukaryotic elongation factor 2 controls TNF-alpha translation in LPS-induced hepatitis. J Clin Invest. 2013 Jan 2;123(1):164-78
All references(84)

Other accession IDs

MGI:1328353, MGI:2144511