Map2k3 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Map2k3
mitogen-activated protein kinase kinase 3
MGI:1346868

13 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Map2k3^tm1Flv/Map2k3^tm1Flv B6.129S1-Map2k3^tm1Flv	increased susceptibility to bacterial infection	J:124327
Map2k3^tm1Flv/Map2k3^tm1Flv B6.129S1-Map2k3^tm1Flv	increased susceptibility to induced morbidity/mortality	J:124327
Map2k3^tm1Flv/Map2k3^tm1Flv involves: 129S1/Sv	abnormal CD4-positive, alpha-beta T cell physiology	J:85266
Map2k3^tm1Flv/Map2k3^tm1Flv involves: 129S1/Sv	decreased T cell apoptosis	J:85266
Tg(Myh6-Map2k3)1Jmol/0 FVB-Tg(Myh6-Map2k3)1Jmol	abnormal heart left ventricle morphology	J:83547
	cardiac hypertrophy	J:83547
	cardiac interstitial fibrosis	J:83547
	cardiomyopathy	J:83547
	decreased cardiac muscle contractility	J:83547
	decreased ventricle muscle contractility	J:83547
	heart left ventricle hypertrophy	J:83547
	increased myocardial fiber size	J:83547
	premature death	J:83547

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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