Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Lmx1b

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes LMX1B
- Mouse genes Lmx1b
- Rat genes Lmx1b
- Zfish genes lmx1ba,lmx1bb
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lmx1b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003700	DNA-binding transcription factor activity	LMX1B	IDA		Human	PMID:10767331
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Lmx1b	IDA		Mouse	MGI:MGI:5705221\|PMID:19951692
Molecular Function	GO:0005515	protein binding	LMX1B	IPI	UniProtKB:Q86U70	Human	PMID:12792813
Molecular Function	GO:0005515	protein binding	Lmx1b	IPI	UniProtKB:Q8R326\|UniProtKB:Q8VIJ6	Mouse	MGI:MGI:5905264\|PMID:23308148
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Lmx1b	IDA		Mouse	MGI:MGI:5705221\|PMID:19951692
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	LMX1B	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	LMX1B	IDA		Human	PMID:10767331
Cellular Component	GO:0005634	nucleus	LMX1B	IDA		Human	PMID:24399192
Cellular Component	GO:0005634	nucleus	Lmx1b	IDA		Mouse	PMID:18076286
Biological Process	GO:0060117	auditory receptor cell development	lmx1bb	IMP	ZFIN:ZDB-GENO-071114-16	Zfish	PMID:17574823
Biological Process	GO:0043010	camera-type eye development	Lmx1b	IMP	MGI:MGI:2158463	Mouse	PMID:10660670
Biological Process	GO:0043010	camera-type eye development	Lmx1b	IMP	MGI:MGI:2158463,MGI:MGI:2386570,MGI:MGI:3714802	Mouse	PMID:20568247
Biological Process	GO:0008283	cell population proliferation	Lmx1b	IMP	MGI:MGI:2158463	Mouse	PMID:17166916
Biological Process	GO:0021954	central nervous system neuron development	Lmx1b	IMP	MGI:MGI:3696968,MGI:MGI:3696982	Mouse	PMID:17151281
Biological Process	GO:0021587	cerebellum morphogenesis	Lmx1b	IMP	MGI:MGI:2158463	Mouse	PMID:17166916
Biological Process	GO:0061386	closure of optic fissure	lmx1bb	IGI	ZFIN:ZDB-MRPHLNO-091218-7,ZFIN:ZDB-MRPHLNO-100629-3	Zfish	PMID:19500562
Biological Process	GO:0061386	closure of optic fissure	lmx1ba	IGI	ZFIN:ZDB-MRPHLNO-091218-7,ZFIN:ZDB-MRPHLNO-100629-3	Zfish	PMID:19500562
Biological Process	GO:0030199	collagen fibril organization	Lmx1b	IMP	MGI:MGI:2158463	Mouse	PMID:10660670
Biological Process	GO:0071542	dopaminergic neuron differentiation	Lmx1b	IGI	UniProtKB:Q9JKU8	Mouse	MGI:MGI:5705221\|PMID:19951692
Biological Process	GO:0071542	dopaminergic neuron differentiation	Lmx1b	IMP	MGI:MGI:2158463	Mouse	PMID:21752929
Biological Process	GO:0009953	dorsal/ventral pattern formation	Lmx1b	IEP		Mouse	MGI:MGI:3687803\|PMID:10767331
Biological Process	GO:0021592	fourth ventricle development	lmx1bb	IGI	ZFIN:ZDB-MRPHLNO-050824-3,ZFIN:ZDB-MRPHLNO-050824-4	Zfish	PMID:18191121
Biological Process	GO:0021592	fourth ventricle development	lmx1ba	IMP	ZFIN:ZDB-MRPHLNO-050824-4	Zfish	PMID:18191121
Biological Process	GO:1905962	glutamatergic neuron differentiation	lmx1bb	IMP		Zfish	PMID:27553035
Biological Process	GO:1905962	glutamatergic neuron differentiation	lmx1ba	IMP		Zfish	PMID:27553035
Biological Process	GO:0030902	hindbrain development	lmx1ba	IMP	ZFIN:ZDB-MRPHLNO-050824-4	Zfish	PMID:18191121
Biological Process	GO:0042472	inner ear morphogenesis	lmx1bb	IMP	ZFIN:ZDB-GENO-071114-16	Zfish	PMID:17574823
Biological Process	GO:0042472	inner ear morphogenesis	lmx1bb	IMP	ZFIN:ZDB-GENO-071114-16	Zfish	PMID:23052906
Biological Process	GO:0042472	inner ear morphogenesis	lmx1bb	IMP	ZFIN:ZDB-MRPHLNO-091218-7	Zfish	PMID:23052906
Biological Process	GO:0035108	limb morphogenesis	Lmx1b	IMP	MGI:MGI:2158463	Mouse	PMID:20589901
Biological Process	GO:0007626	locomotory behavior	Lmx1b	IGI	UniProtKB:Q9JKU8	Mouse	MGI:MGI:5645828\|PMID:25915474
Biological Process	GO:0007613	memory	Lmx1b	IGI	UniProtKB:Q9JKU8	Mouse	MGI:MGI:5645828\|PMID:25915474
Biological Process	GO:0030901	midbrain development	Lmx1b	IMP	MGI:MGI:2158463	Mouse	PMID:21752929
Biological Process	GO:0030917	midbrain-hindbrain boundary development	lmx1bb	IGI	ZFIN:ZDB-MRPHLNO-050824-3,ZFIN:ZDB-MRPHLNO-050824-4	Zfish	PMID:15944182
Biological Process	GO:0030917	midbrain-hindbrain boundary development	lmx1ba	IGI	ZFIN:ZDB-MRPHLNO-050824-3,ZFIN:ZDB-MRPHLNO-050824-4	Zfish	PMID:15944182
Biological Process	GO:0030182	neuron differentiation	Lmx1b	IMP	MGI:MGI:2158463	Mouse	PMID:12897786
Biological Process	GO:0030182	neuron differentiation	Lmx1b	IMP	MGI:MGI:2158463	Mouse	PMID:15229182
Biological Process	GO:0001764	neuron migration	Lmx1b	IMP	MGI:MGI:2158463	Mouse	PMID:15229182
Biological Process	GO:0042048	olfactory behavior	Lmx1b	IGI	UniProtKB:Q9JKU8	Mouse	MGI:MGI:5645828\|PMID:25915474
Biological Process	GO:0002072	optic cup morphogenesis involved in camera-type eye development	lmx1bb	IGI	ZFIN:ZDB-MRPHLNO-091218-7,ZFIN:ZDB-MRPHLNO-100629-3	Zfish	PMID:19500562
Biological Process	GO:0002072	optic cup morphogenesis involved in camera-type eye development	lmx1ba	IGI	ZFIN:ZDB-MRPHLNO-091218-7,ZFIN:ZDB-MRPHLNO-100629-3	Zfish	PMID:19500562
Biological Process	GO:0035265	organ growth	Lmx1b	IMP	MGI:MGI:2158463	Mouse	PMID:17166916
Biological Process	GO:0032474	otolith morphogenesis	lmx1bb	IMP	ZFIN:ZDB-GENO-071114-16	Zfish	PMID:17574823
Biological Process	GO:0072015	podocyte development	lmx1bb	IGI	ZFIN:ZDB-MRPHLNO-050824-3,ZFIN:ZDB-MRPHLNO-061111-2	Zfish	PMID:24854274
Biological Process	GO:0072015	podocyte development	lmx1bb	IMP	ZFIN:ZDB-MRPHLNO-050824-3	Zfish	PMID:24854274
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lmx1b	IDA		Mouse	MGI:MGI:5705221\|PMID:19951692
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lmx1b	IMP		Mouse	MGI:MGI:5645828\|PMID:25915474
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lmx1b	IMP	MGI:MGI:2158463	Mouse	PMID:17166916
Biological Process	GO:0035775	pronephric glomerulus morphogenesis	lmx1bb	IGI	ZFIN:ZDB-MRPHLNO-050824-3,ZFIN:ZDB-MRPHLNO-050824-4,ZFIN:ZDB-MRPHLNO-140317-1	Zfish	PMID:23990680
Biological Process	GO:0035775	pronephric glomerulus morphogenesis	lmx1bb	IGI	ZFIN:ZDB-MRPHLNO-050824-3,ZFIN:ZDB-MRPHLNO-050824-4	Zfish	PMID:23990680
Biological Process	GO:0035775	pronephric glomerulus morphogenesis	lmx1ba	IGI	ZFIN:ZDB-MRPHLNO-050824-3,ZFIN:ZDB-MRPHLNO-050824-4,ZFIN:ZDB-MRPHLNO-140317-1	Zfish	PMID:23990680
Biological Process	GO:0035775	pronephric glomerulus morphogenesis	lmx1ba	IGI	ZFIN:ZDB-MRPHLNO-050824-3,ZFIN:ZDB-MRPHLNO-050824-4	Zfish	PMID:23990680
Biological Process	GO:0010506	regulation of autophagy	Lmx1b	IMP		Mouse	MGI:MGI:5645828\|PMID:25915474
Biological Process	GO:0006355	regulation of DNA-templated transcription	LMX1B	IDA		Human	PMID:10767331
Biological Process	GO:0010468	regulation of gene expression	Lmx1b	IMP	MGI:MGI:2158463	Mouse	PMID:20589901
Biological Process	GO:0032386	regulation of intracellular transport	Lmx1b	IMP		Mouse	MGI:MGI:5645828\|PMID:25915474
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Lmx1b	IDA		Mouse	PMID:21752929
Biological Process	GO:0060041	retina development in camera-type eye	lmx1bb	IGI	ZFIN:ZDB-MRPHLNO-091218-7,ZFIN:ZDB-MRPHLNO-100629-3	Zfish	PMID:19500562
Biological Process	GO:0060041	retina development in camera-type eye	lmx1ba	IGI	ZFIN:ZDB-MRPHLNO-091218-7,ZFIN:ZDB-MRPHLNO-100629-3	Zfish	PMID:19500562
Biological Process	GO:0048752	semicircular canal morphogenesis	lmx1bb	IMP	ZFIN:ZDB-GENO-071114-16	Zfish	PMID:17574823
Biological Process	GO:0050808	synapse organization	Lmx1b	IGI	UniProtKB:Q9JKU8	Mouse	MGI:MGI:5645828\|PMID:25915474
Biological Process	GO:0002930	trabecular meshwork development	Lmx1b	IMP	MGI:MGI:2158463,MGI:MGI:2386570,MGI:MGI:3714802	Mouse	PMID:20568247

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.