Lmx1b
Gene Detail

Symbol Name ID

Lmx1b LIM homeobox transcription factor 1 beta MGI:1100513

Synonyms

LMX1.2

Feature Type

protein coding gene

Genetic Map

Chromosome 2

22.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr2:33560965-33640511 bp, - strand From VEGA annotation of GRCm38   79547 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55648  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor isl-1
Gene Tree: Lmx1b

Human homologs

Human Homolog		LMX1B, LIM homeobox transcription factor 1, beta
NCBI Gene ID		4010
neXtProt AC		NX_O60663
Human Synonyms		LMX1.2, NPS1
Human Chr (Location)		9q33.3; chr9:129376722-129463311 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LMX1B

Alleles and phenotypes

All alleles(15) : Targeted(11) Gene trapped(4)
 

Homozygotes for a targeted null mutation exhibit a lack of patellae, nails, ulna, and ilium, abnormal calvaria, microphthalmia with anterior segment defects, and dysplastic kidneys. Mutants lack serotonergic neurons and fail to suckle.

 
Human Diseases Modeled Using Mouse Lmx1b (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(6)

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	camera-type eye development, cell death, ...
Component	nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (158 records)
Data Summary: Results (296)    Tissues (213)    Images (95)
Theiler Stages: 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	292

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(1) cDNA(15) Primer pair(2) Other(6)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000012589 (Evidence)
Ensembl Gene Model	ENSMUSG00000038765 (Evidence)
Entrez Gene	16917 (Evidence)
UniGene	39825
DoTS	DT.91328647
NIA Mouse Gene Index	U022521
Consensus CDS Project	CCDS15944.1
International Mouse Knockout Project Status	Lmx1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012589	VEGA Gene Model | MGI Sequence Detail	79547	C57BL/6J
transcript	OTTMUST00000029994	VEGA | MGI Sequence Detail	4790	Not Applicable
polypeptide	OTTMUSP00000013489	VEGA | MGI Sequence Detail	372	Not Applicable

All sequences(26) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(161 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR001781	Zinc finger, LIM-type
Protein Ontology	PR:000009871	LIM homeobox transcription factor 1-beta

References

(Earliest) J:43464 Matise MP, et al., Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons. J Neurosci. 1997 Oct 15;17(20):7805-16
(Latest) J:192558 Rabe TI, et al., The transcription factor Uncx4.1 acts in a short window of midbrain dopaminergic neuron differentiation. Neural Dev. 2012;7:39
All references(201)