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Lmx1b
Gene Detail
 Symbol
Name
ID
Lmx1b
LIM homeobox transcription factor 1 beta
MGI:1100513
Synonyms LMX1.2
Feature Type protein coding gene
Genetic Map
Chromosome 2
22.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:33560965-33640511 bp, - strand
From VEGA annotation of GRCm38

  79547 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55648  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor isl-1
Gene Tree: Lmx1b

Human
homologs
Human Homolog LMX1B, LIM homeobox transcription factor 1, beta
NCBI Gene ID 4010
neXtProt AC  NX_O60663
Human Synonyms  LMX1.2, NPS1
Human Chr (Location)  9q33.3; chr9:126614443-126701032 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LMX1B
Alleles
and
phenotypes
All alleles(15) : Targeted(11) Gene trapped(4)
 
Homozygotes for a targeted null mutation exhibit a lack of patellae, nails, ulna, and ilium, abnormal calvaria, microphthalmia with anterior segment defects, and dysplastic kidneys. Mutants lack serotonergic neurons and fail to suckle.
 
Human Diseases Modeled Using Mouse Lmx1b (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(6)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process camera-type eye development, cell death, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (162 records)
Data Summary: Results (313)    Tissues (219)    Images (109)
Theiler Stages: 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 301
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(15) Primer pair(2) Other(8)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000012589 (Evidence)
Ensembl Gene ModelENSMUSG00000038765 (Evidence)
Entrez Gene16917 (Evidence)
UniGene39825
DoTSDT.91328647
NIA Mouse Gene IndexU022521
Consensus CDS ProjectCCDS15944.1
International Mouse Knockout Project StatusLmx1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012589 VEGA Gene Model | MGI Sequence Detail 79547 C57BL/6J ±  kb
transcript OTTMUST00000029994 VEGA | MGI Sequence Detail 4790 Not Applicable 
polypeptide OTTMUSP00000013489 VEGA | MGI Sequence Detail 372 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(8) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(214 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009871 LIM homeobox transcription factor 1-beta
References (Earliest) J:43464 Matise MP, et al., Expression patterns of developmental control genes in normal and Engrailed-1 mutant mouse spinal cord reveal early diversity in developing interneurons. J Neurosci. 1997 Oct 15;17(20):7805-16
(Latest) J:205591 Corcoran AE, et al., Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice. J Neurosci. 2014 Jan 1;34(1):51-9
All references(210)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory