Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LHX2
  • Mouse genes Lhx2
  • Rat genes Lhx2
  • Zfish genes lhx2a,lhx2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lhx2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003682	chromatin binding	Lhx2	IDA		Mouse	PMID:19146846
Molecular Function	GO:0003682	chromatin binding	Lhx2	IDA		Mouse	PMID:24012369
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Lhx2	IMP		Mouse	MGI:MGI:5825442|PMID:7513049
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Lhx2	IDA		Mouse	MGI:MGI:5825442|PMID:7513049
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Lhx2	IMP		Mouse	MGI:MGI:5699500|PMID:26371318
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q86U70	Human	PMID:20211142
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:A7KAX9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:P0CB47	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:P31273	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:P50053-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q12837	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q17RB8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q3ZCW2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q49AR9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q4VC44	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q6PF18	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q86U70-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q8N8B7-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q8NB15	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q8NDZ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q8TBB1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q96MM3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q99650	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q9NSC5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q9NUJ3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q9UBU8-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q9UKI8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q9UL33-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q9Y3C6	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	LHX2	IPI	UniProtKB:Q86U70	Human	PMID:35140242
Molecular Function	GO:0005515	protein binding	Lhx2	IPI	UniProtKB:O35740	Mouse	MGI:MGI:5009206|PMID:10593900
Molecular Function	GO:0005515	protein binding	Lhx2	IPI	UniProtKB:P70288,UniProtKB:Q60972,UniProtKB:Q6ZQ88	Mouse	MGI:MGI:5817507|PMID:28053041
Molecular Function	GO:0005515	protein binding	Lhx2	IPI	UniProtKB:Q63934-1	Mouse	MGI:MGI:5825419|PMID:24643061
Molecular Function	GO:0005515	protein binding	Lhx2	IPI	UniProtKB:Q15327	Mouse	MGI:MGI:5294529|PMID:20599664
Molecular Function	GO:0005515	protein binding	Lhx2	IPI	PR:P13297	Mouse	PMID:9697309
Molecular Function	GO:0005515	protein binding	Lhx2	IPI	PR:Q9WTV7	Mouse	PMID:10431247
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Lhx2	IMP		Mouse	MGI:MGI:5817507|PMID:28053041
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Lhx2	IMP		Mouse	MGI:MGI:5825442|PMID:7513049
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Lhx2	IDA		Mouse	MGI:MGI:3044864|PMID:15173589
Molecular Function	GO:0043565	sequence-specific DNA binding	Lhx2	IDA		Mouse	PMID:15173589
Molecular Function	GO:0008134	transcription factor binding	Lhx2	IPI	PR:P70662	Mouse	PMID:17991461
Cellular Component	GO:0005622	intracellular anatomical structure	Lhx2	IDA		Mouse	PMID:10482234
Cellular Component	GO:0005634	nucleus	Lhx2	IMP		Mouse	MGI:MGI:5817507|PMID:28053041
Cellular Component	GO:0005634	nucleus	Lhx2	IMP		Mouse	MGI:MGI:5699500|PMID:26371318
Cellular Component	GO:0005634	nucleus	Lhx2	IDA		Mouse	PMID:18076286
Cellular Component	GO:0005634	nucleus	Lhx2	IDA		Mouse	PMID:24012369
Biological Process	GO:0048646	anatomical structure formation involved in morphogenesis	Lhx2	IMP	MGI:MGI:1890208	Mouse	PMID:11719201
Biological Process	GO:0048675	axon extension	Lhx2	IDA		Mouse	PMID:21857657
Biological Process	GO:0007411	axon guidance	Lhx2	IMP		Mouse	MGI:MGI:5319439|PMID:22457488
Biological Process	GO:0007411	axon guidance	Lhx2	IMP	MGI:MGI:1890208	Mouse	PMID:17493606
Biological Process	GO:0007411	axon guidance	lhx2b	IMP	ZFIN:ZDB-GENO-050209-9	Zfish	PMID:16436624
Biological Process	GO:0007420	brain development	Lhx2	IMP	MGI:MGI:1890208	Mouse	PMID:14566948
Biological Process	GO:0007420	brain development	Lhx2	IMP	MGI:MGI:1890208	Mouse	PMID:15295034
Biological Process	GO:0007420	brain development	lhx2b	IMP	ZFIN:ZDB-MRPHLNO-051220-7	Zfish	PMID:16226737
Biological Process	GO:0043010	camera-type eye development	lhx2b	IMP	ZFIN:ZDB-GENO-050209-9	Zfish	PMID:16436624
Biological Process	GO:0021987	cerebral cortex development	Lhx2	IMP		Mouse	MGI:MGI:5817507|PMID:28053041
Biological Process	GO:0021987	cerebral cortex development	Lhx2	IMP		Mouse	MGI:MGI:5699500|PMID:26371318
Biological Process	GO:0021987	cerebral cortex development	Lhx2	IMP	MGI:MGI:4399044	Mouse	PMID:19820705
Biological Process	GO:0009953	dorsal/ventral pattern formation	Lhx2	IMP	MGI:MGI:1890208	Mouse	PMID:11165475
Biological Process	GO:0009953	dorsal/ventral pattern formation	Lhx2	IMP	MGI:MGI:1890208	Mouse	PMID:14566948
Biological Process	GO:0030900	forebrain development	lhx2b	IMP	ZFIN:ZDB-GENO-050209-9	Zfish	PMID:16436624
Biological Process	GO:0001942	hair follicle development	Lhx2	IMP	MGI:MGI:1926500,MGI:MGI:3772179	Mouse	PMID:24012369
Biological Process	GO:0045199	maintenance of epithelial cell apical/basal polarity	Lhx2	IMP	MGI:MGI:1926500,MGI:MGI:3772179	Mouse	PMID:24012369
Biological Process	GO:0007498	mesoderm development	Lhx2	IMP	MGI:MGI:1890208	Mouse	PMID:9247336
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	Lhx2	IMP		Mouse	MGI:MGI:5817507|PMID:28053041
Biological Process	GO:0050768	negative regulation of neurogenesis	Lhx2	IMP		Mouse	MGI:MGI:5699500|PMID:26371318
Biological Process	GO:0050768	negative regulation of neurogenesis	Lhx2	IMP		Mouse	MGI:MGI:5817507|PMID:28053041
Biological Process	GO:2000678	negative regulation of transcription regulatory region DNA binding	Lhx2	IGI	MGI:MGI:97168	Mouse	PMID:9697309
Biological Process	GO:0007399	nervous system development	Lhx2	IMP	MGI:MGI:1890208	Mouse	PMID:9247336
Biological Process	GO:0001843	neural tube closure	Lhx2	IMP	MGI:MGI:1890208	Mouse	PMID:11719201
Biological Process	GO:0022008	neurogenesis	Lhx2	IDA		Mouse	PMID:18184563
Biological Process	GO:0030182	neuron differentiation	Lhx2	IMP	MGI:MGI:1890208	Mouse	PMID:15173589
Biological Process	GO:0030182	neuron differentiation	Lhx2	IEP		Rat	PMID:7678338|RGD:70777
Biological Process	GO:0021772	olfactory bulb development	Lhx2	IMP	MGI:MGI:4399044	Mouse	PMID:19820705
Biological Process	GO:0021554	optic nerve development	lhx2b	IMP	ZFIN:ZDB-GENO-080327-301	Zfish	PMID:23238723
Biological Process	GO:0007634	optokinetic behavior	lhx2b	IMP	ZFIN:ZDB-GENO-980202-840	Zfish	PMID:17005851
Biological Process	GO:0071632	optomotor response	lhx2b	IMP	ZFIN:ZDB-GENO-080327-301	Zfish	PMID:23238723
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Lhx2	IDA		Mouse	MGI:MGI:5009206|PMID:10593900
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Lhx2	IMP		Mouse	MGI:MGI:5619740|PMID:22734700
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	Lhx2	IMP		Mouse	MGI:MGI:5699500|PMID:26371318
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx2	IMP		Mouse	MGI:MGI:5699500|PMID:26371318
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx2	IDA		Mouse	MGI:MGI:5825442|PMID:7513049
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx2	IDA		Mouse	MGI:MGI:3836385|PMID:19146846
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx2	IGI	MGI:MGI:97490	Mouse	PMID:19146846
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx2	IDA		Mouse	PMID:24012369
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Lhx2	IGI	MGI:MGI:1342291	Mouse	PMID:10431247
Biological Process	GO:0010468	regulation of gene expression	lhx2b	IMP	ZFIN:ZDB-GENO-050209-9	Zfish	PMID:12538521
Biological Process	GO:0009416	response to light stimulus	lhx2b	IMP	ZFIN:ZDB-GENO-080327-301	Zfish	PMID:23238723
Biological Process	GO:0060041	retina development in camera-type eye	Lhx2	IGI	MGI:MGI:97490	Mouse	PMID:19146846
Biological Process	GO:0031290	retinal ganglion cell axon guidance	lhx2b	IMP	ZFIN:ZDB-GENO-050209-9	Zfish	PMID:16436624
Biological Process	GO:0031290	retinal ganglion cell axon guidance	lhx2b	IMP	ZFIN:ZDB-GENO-980202-840	Zfish	PMID:9007260
Biological Process	GO:0021537	telencephalon development	Lhx2	IMP	MGI:MGI:1890208	Mouse	PMID:11165475
Biological Process	GO:0021537	telencephalon development	Lhx2	IMP	MGI:MGI:1890208	Mouse	PMID:17493606
Biological Process	GO:0021537	telencephalon development	Lhx2	IMP	MGI:MGI:4399044	Mouse	PMID:19820705
Biological Process	GO:0021537	telencephalon development	Lhx2	IMP	MGI:MGI:1890208	Mouse	PMID:11719201
Biological Process	GO:0021537	telencephalon development	lhx2b	IMP		Zfish	PMID:16614871
Biological Process	GO:0021978	telencephalon regionalization	Lhx2	IGI	MGI:MGI:88180	Mouse	PMID:11719201
Biological Process	GO:0021978	telencephalon regionalization	Lhx2	IGI	MGI:MGI:88177	Mouse	PMID:11719201
Biological Process	GO:0021978	telencephalon regionalization	Lhx2	IMP	MGI:MGI:1890208	Mouse	PMID:11719201
Biological Process	GO:0021794	thalamus development	lhx2b	IGI	ZFIN:ZDB-MRPHLNO-120201-1,ZFIN:ZDB-MRPHLNO-120202-5	Zfish	PMID:22180728

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern