About   Help   FAQ
Lhx2
Gene Detail
Symbol

Name
ID
Lhx2
LIM homeobox protein 2
MGI:96785
Synonyms
ap, apterous, Lh-2, LH2A
Feature Type
protein coding gene
Genetic Map
Chromosome 2
24.31 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:38339281-38369733 bp, + strand
From VEGA annotation of GRCm38

  30453 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55848  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LHX2
Gene Tree: Lhx2

Human
homologs
LHX2, LIM homeobox 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9355
neXtProt AC: NX_P50458

Human Synonyms: hLhx2, LH2

Human Chr (Location): 9q33.3; chr9:124011610-124033163 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(9)
 
Mice homozygous for a knock-out allele exhibit lethality during fetal development and the perinatal period with abnormal liver, telencephalon, olfactory bulb, basal ganglion, and eye morphology.
 
Interactions
Lhx2 interacts with 193 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process anatomical structure formation involved in morphogenesis, axon extension, ...
Component intracellular, nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (213 records)
Data Summary: Results (551)    Tissues (302)    Images (143)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 512
RT-PCR 36
cDNA source data(41)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA LHX2 ; Xenbase lhx2 ; ZFIN lhx2a, lhx2b    NEW 
Molecular
reagents
All nucleic(55) cDNA(45) Primer pair(2) Other(8)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000012866 (Evidence)
Ensembl Gene Model ENSMUSG00000000247 (Evidence)
Entrez Gene 16870 (Evidence)
UniGene 142856
DFCI TC1580161, TC1622069
DoTS DT.101734592, DT.40168323, DT.94188811
NIA Mouse Gene Index U001694
Consensus CDS Project CCDS16008.1, CCDS71048.1
International Mouse Phenotyping Consortium Status Lhx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012866 VEGA Gene Model | MGI Sequence Detail 30453 C57BL/6J ±  kb
transcript OTTMUST00000030849 VEGA | MGI Sequence Detail 2840 Not Applicable 
polypeptide OTTMUSP00000013821 VEGA | MGI Sequence Detail 406 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(16) UniProt(6)
Polymorphisms
SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009792 LIM/homeobox protein Lhx2
References
(Earliest) J:3610 Xu Y, et al., LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):227-31
(Latest) J:220860 Magnani D, et al., The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 2015 May 1;24(9):2578-93
All references(252)
Other
accession IDs
MGD-MRK-11805

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory