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Lhx2
Gene Detail
 Symbol
Name
ID
Lhx2
LIM homeobox protein 2
MGI:96785
Synonyms ap, apterous, Lh-2, LH2A
Feature Type protein coding gene
Genetic Map
Chromosome 2
24.31 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:38339281-38369733 bp, + strand
From VEGA annotation of GRCm38

  30453 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55848  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lhx2

Human
homologs
Human Homolog LHX2, LIM homeobox 2
NCBI Gene ID 9355
neXtProt AC  NX_P50458
Human Synonyms  hLhx2, LH2
Human Chr (Location)  9q33.3; chr9:124011610-124033163 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(9)
 
Mice homozygous for a knock-out allele exhibit lethality during fetal development and the perinatal period with abnormal liver, telencephalon, olfactory bulb, basal ganglion, and eye morphology.
 
Interactions
Lhx2 interacts with 193 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process anatomical structure formation involved in morphogenesis, axon extension, ...
Component intracellular, nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (194 records)
Data Summary: Results (547)    Tissues (300)    Images (142)
Theiler Stages: 2, 3, 12, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 508
RT-PCR 36
cDNA source data(41)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) cDNA(45) Primer pair(2) Other(7)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000012866 (Evidence)
Ensembl Gene ModelENSMUSG00000000247 (Evidence)
Entrez Gene16870 (Evidence)
UniGene142856
DFCITC1580161, TC1622069
DoTSDT.101734592, DT.40168323, DT.94188811
NIA Mouse Gene IndexU001694
Consensus CDS ProjectCCDS16008.1, CCDS71048.1
International Mouse Knockout Project StatusLhx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012866 VEGA Gene Model | MGI Sequence Detail 30453 C57BL/6J ±  kb
transcript OTTMUST00000030849 VEGA | MGI Sequence Detail 2840 Not Applicable 
polypeptide OTTMUSP00000013821 VEGA | MGI Sequence Detail 406 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(16) UniProt(5)
Polymorphisms SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009792 LIM/homeobox protein Lhx2
References (Earliest) J:3610 Xu Y, et al., LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):227-31
(Latest) J:208421 Klimova L, et al., Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development. 2014 Mar;141(6):1292-302
All references(234)
Other
accession IDs
MGD-MRK-11805

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory