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Lhx2 Gene Detail
Summary
  • Symbol
    Lhx2
  • Name
    LIM homeobox protein 2
  • Synonyms
    ap, apterous, Lh-2, LH2A
  • Feature Type
    protein coding gene
  • IDs
    MGI:96785
    NCBI Gene: 16870
  • Gene Overview
    MyGene.info: LHX2
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:38339281-38369733 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 24.31 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96785
protein coding gene Chr2:38339281-38369737 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025701
protein coding gene Chr2:37086076-37117411 (+)
A/J MGP_AJ_G0025678
protein coding gene Chr2:35560748-35591623 (+)
AKR/J MGP_AKRJ_G0025648
protein coding gene Chr2:36739364-36771172 (+)
BALB/cJ MGP_BALBcJ_G0025673
protein coding gene Chr2:35614892-35645968 (+)
C3H/HeJ MGP_C3HHeJ_G0025434
protein coding gene Chr2:36653694-36685039 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026119
protein coding gene Chr2:38121222-38151344 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023524
protein coding gene Chr2:34216444-34246697 (+)
CAST/EiJ MGP_CASTEiJ_G0024897
protein coding gene Chr2:36597805-36629097 (+)
CBA/J MGP_CBAJ_G0025413
protein coding gene Chr2:39554888-39585177 (+)
DBA/2J MGP_DBA2J_G0025545
protein coding gene Chr2:35309099-35339512 (+)
FVB/NJ MGP_FVBNJ_G0025507
protein coding gene Chr2:35176157-35206713 (+)
LP/J MGP_LPJ_G0025632
protein coding gene Chr2:36969796-37001060 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025538
protein coding gene Chr2:39170611-39200810 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026177
protein coding gene Chr2:36628457-36659873 (+)
PWK/PhJ MGP_PWKPhJ_G0024639
protein coding gene Chr2:35208906-35239323 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024444
protein coding gene Chr2:36739367-36769249 (+)
WSB/EiJ MGP_WSBEiJ_G0024965
protein coding gene Chr2:36791955-36826432 (+)



Homology
more
  • Human Ortholog
    LHX2, LIM homeobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LHX2, LIM homeobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hLhx2, LH2
  • Links
    NCBI Gene ID: 9355
    neXtProt AC: NX_P50458
    UniProt: P50458

  • Chr Location
    9q33.3; chr9:124011610-124033163 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55848
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LHX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 8 alleles in 14 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality during fetal development and the perinatal period with abnormal liver, telencephalon, olfactory bulb, basal ganglion, and eye morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000247 Ensembl Gene Model | MGI Sequence Detail 30453 C57BL/6J ±  kb
    transcript ENSMUST00000000253 Ensembl | MGI Sequence Detail 2840 Not Applicable  
    polypeptide ENSMUSP00000000253 Ensembl | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 47
      Primer pair 2
      Other 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11805
    References
    more
    • Summaries
      All 318
      Developmental Gene Expression 263
      Gene Ontology 28
      Phenotypes 62
    • Earliest
      J:3610 Xu Y, et al., LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):227-31
    • Latest
      J:278245 Guo Q, et al., Defining developmental diversification of diencephalon neurons through single cell gene expression profiling. Development. 2019 Apr 1;146(12)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory