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Lhx2 Gene Detail
Summary
  • Symbol
    Lhx2
  • Name
    LIM homeobox protein 2
  • Synonyms
    ap, apterous, Lh-2, LH2A
  • Feature Type
    protein coding gene
  • IDs
    MGI:96785
    NCBI Gene: 16870
  • Gene Overview
    MyGene.info: LHX2
Location & Maps
more
  • Sequence Map
    Chr2:38339281-38369733 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30453 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 24.31 cM, cytoband B
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    LHX2, LIM homeobox 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LHX2, LIM homeobox 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hLhx2, LH2
  • Links
    NCBI Gene ID: 9355
    neXtProt AC: NX_P50458

  • Chr Location
    9q33.3; chr9:124011610-124033163 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55848
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LHX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    34 phenotypes from 8 alleles in 14 genetic backgrounds
    3 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    1
  • Targeted
    9
  • Transgenic
    1
Mice homozygous for a knock-out allele exhibit lethality during fetal development and the perinatal period with abnormal liver, telencephalon, olfactory bulb, basal ganglion, and eye morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012866 VEGA Gene Model | MGI Sequence Detail 30453 C57BL/6J ±  kb
transcript OTTMUST00000030849 VEGA | MGI Sequence Detail 2840 Not Applicable  
polypeptide OTTMUSP00000013821 VEGA | MGI Sequence Detail 406 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    53 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 57
    cDNA 45
    Primer pair 2
    Other 10

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11805
References
more
  • Summaries
    All 267
    Developmental Gene Expression 227
    Gene Ontology 23
    Phenotypes 46
  • Earliest
    J:3610 Xu Y, et al., LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):227-31
  • Latest
    J:233763 Karpinski BA, et al., A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons. Dev Biol. 2016 Jul 15;415(2):228-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory