Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Lgals1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes LGALS1
- Mouse genes Lgals1
- Rat genes Lgals1
- Zfish genes lgals1l1,lgals2a,lgals2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lgals1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0030246	carbohydrate binding	Lgals1	IDA		Mouse	PMID:21753146
Molecular Function	GO:0016936	galactoside binding	lgals2a	IDA		Zfish	PMID:14693912
Molecular Function	GO:0042802	identical protein binding	Lgals1	IPI	RGD:69355	Rat	PMID:10814697\|RGD:1643027
Molecular Function	GO:0030395	lactose binding	Lgals1	IDA		Rat	PMID:1955484\|RGD:2316546
Molecular Function	GO:0043236	laminin binding	Lgals1	IDA		Rat	PMID:1955484\|RGD:2316546
Molecular Function	GO:0043236	laminin binding	lgals2a	IDA		Zfish	PMID:14693912
Molecular Function	GO:0005515	protein binding	LGALS1	IPI	UniProtKB:P08575	Human	PMID:10369126
Molecular Function	GO:0005515	protein binding	LGALS1	IPI	UniProtKB:Q9UGT4	Human	PMID:23131994
Molecular Function	GO:0005515	protein binding	LGALS1	IPI	UniProtKB:P35968	Human	PMID:24529377
Molecular Function	GO:0005515	protein binding	LGALS1	IPI	UniProtKB:P30203	Human	PMID:24945728
Molecular Function	GO:0005515	protein binding	LGALS1	IPI	UniProtKB:Q13740	Human	PMID:24945728
Molecular Function	GO:0005515	protein binding	LGALS1	IPI	UniProtKB:P16284	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	LGALS1	IPI	UniProtKB:P02649	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS1	IPI	UniProtKB:P16284	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS1	IPI	UniProtKB:P27797	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS1	IPI	UniProtKB:P36957	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	LGALS1	IPI	UniProtKB:Q8TDX7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Lgals1	IPI	PR:Q8BV57	Mouse	PMID:21217009
Molecular Function	GO:0005515	protein binding	Lgals1	IPI	RGD:3451	Rat	PMID:10814697\|RGD:1643027
Molecular Function	GO:0005515	protein binding	Lgals1	IPI	RGD:3860	Rat	PMID:10814697\|RGD:1643027
Molecular Function	GO:0003723	RNA binding	LGALS1	HDA		Human	PMID:22658674
Cellular Component	GO:0009986	cell surface	Lgals1	IDA		Rat	PMID:1955484\|RGD:2316546
Cellular Component	GO:0062023	collagen-containing extracellular matrix	LGALS1	HDA		Human	PMID:20551380
Cellular Component	GO:0062023	collagen-containing extracellular matrix	LGALS1	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	LGALS1	HDA		Human	PMID:23979707
Cellular Component	GO:0062023	collagen-containing extracellular matrix	LGALS1	HDA		Human	PMID:27559042
Cellular Component	GO:0062023	collagen-containing extracellular matrix	LGALS1	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	LGALS1	HDA		Human	PMID:28675934
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Lgals1	HDA		Mouse	MGI:MGI:6201853\|PMID:28071719
Cellular Component	GO:0005737	cytoplasm	Lgals1	IDA		Rat	PMID:16673152\|RGD:9685215
Cellular Component	GO:0005829	cytosol	Lgals1	IDA		Rat	PMID:19616040\|RGD:2314839
Cellular Component	GO:0070062	extracellular exosome	LGALS1	HDA		Human	PMID:23533145
Cellular Component	GO:0005576	extracellular region	LGALS1	HDA		Human	PMID:27068509
Cellular Component	GO:0005615	extracellular space	LGALS1	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	Lgals1	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Lgals1	IDA		Mouse	PMID:11839787
Cellular Component	GO:1990724	galectin complex	LGALS1	IPI		Human	PMID:15476813
Cellular Component	GO:0005634	nucleus	Lgals1	IDA		Rat	PMID:16673152\|RGD:9685215
Cellular Component	GO:0005634	nucleus	Lgals1	IDA		Rat	PMID:19079321\|RGD:2316526
Biological Process	GO:0098609	cell-cell adhesion	LGALS1	IDA		Human	PMID:18796645
Biological Process	GO:0071333	cellular response to glucose stimulus	Lgals1	IEP		Rat	PMID:19125585\|RGD:2316521
Biological Process	GO:0071407	cellular response to organic cyclic compound	Lgals1	IEP		Rat	PMID:17316808\|RGD:2316540
Biological Process	GO:0045445	myoblast differentiation	Lgals1	IDA		Mouse	PMID:11839787
Biological Process	GO:0010812	negative regulation of cell-substrate adhesion	Lgals1	IDA		Rat	PMID:1955484\|RGD:2316546
Biological Process	GO:0010977	negative regulation of neuron projection development	Lgals1	IMP		Rat	PMID:17486104\|RGD:2316537
Biological Process	GO:0002317	plasma cell differentiation	Lgals1	IDA		Mouse	PMID:21753146
Biological Process	GO:0043065	positive regulation of apoptotic process	LGALS1	IDA		Human	PMID:12730878
Biological Process	GO:0034120	positive regulation of erythrocyte aggregation	Lgals1	IDA		Rat	PMID:3800956\|RGD:2316548
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	LGALS1	HMP		Human	PMID:12761501
Biological Process	GO:0050729	positive regulation of inflammatory response	LGALS1	IDA		Human	PMID:12730878
Biological Process	GO:0050769	positive regulation of neurogenesis	lgals2a	IMP	ZFIN:ZDB-MRPHLNO-101117-6	Zfish	PMID:20071673
Biological Process	GO:0046598	positive regulation of viral entry into host cell	LGALS1	IDA		Human	PMID:21670307
Biological Process	GO:0090303	positive regulation of wound healing	lgals2a	IMP	ZFIN:ZDB-MRPHLNO-101117-6	Zfish	PMID:20071673
Biological Process	GO:0048678	response to axon injury	Lgals1	IEP		Rat	PMID:18850073\|RGD:2316527
Biological Process	GO:0035900	response to isolation stress	Lgals1	IEP		Rat	PMID:19616040\|RGD:2314839
Biological Process	GO:0009410	response to xenobiotic stimulus	Lgals1	IEP		Rat	PMID:17490626\|RGD:2316530
Biological Process	GO:0048741	skeletal muscle fiber development	lgals2a	IMP	ZFIN:ZDB-MRPHLNO-090717-1	Zfish	PMID:18763034
Biological Process	GO:0002040	sprouting angiogenesis	lgals2b	IGI	ZFIN:ZDB-MRPHLNO-061122-2,ZFIN:ZDB-MRPHLNO-061122-5	Zfish	PMID:17043243
Biological Process	GO:0002040	sprouting angiogenesis	lgals2b	IGI	ZFIN:ZDB-MRPHLNO-061122-3,ZFIN:ZDB-MRPHLNO-061122-4	Zfish	PMID:17043243
Biological Process	GO:0002040	sprouting angiogenesis	lgals2a	IGI	ZFIN:ZDB-MRPHLNO-061122-2,ZFIN:ZDB-MRPHLNO-061122-5	Zfish	PMID:17043243
Biological Process	GO:0002040	sprouting angiogenesis	lgals2a	IGI	ZFIN:ZDB-MRPHLNO-061122-3,ZFIN:ZDB-MRPHLNO-061122-4	Zfish	PMID:17043243
Biological Process	GO:0031295	T cell costimulation	Lgals1	IDA		Mouse	PMID:22357632
Biological Process	GO:0001944	vasculature development	lgals2b	IMP	ZFIN:ZDB-MRPHLNO-061122-5	Zfish	PMID:17043243
Biological Process	GO:0001944	vasculature development	lgals2b	IMP	ZFIN:ZDB-MRPHLNO-061122-4	Zfish	PMID:17043243
Biological Process	GO:0001944	vasculature development	lgals2a	IMP	ZFIN:ZDB-MRPHLNO-061122-2	Zfish	PMID:17043243
Biological Process	GO:0001944	vasculature development	lgals2a	IMP	ZFIN:ZDB-MRPHLNO-061122-3	Zfish	PMID:17043243

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.