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Lgals1
Gene Detail
Symbol

Name
ID
Lgals1
lectin, galactose binding, soluble 1
MGI:96777
Synonyms
Gal-1, Galbp, galectin-1, L14, Lect14
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.70 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr15:78926725-78930465 bp, + strand
From NCBI annotation of GRCm38

  3741 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7399  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: LGALS1
Protein SuperFamily: beta-galactoside-binding lectin
Gene Tree: Lgals1

Human
homologs
LGALS1, lectin, galactoside-binding, soluble, 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3956
neXtProt AC: NX_P09382

Human Synonyms: GAL1, GBP

Human Chr (Location): 22q13.1; chr22:37675606-37679802 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(64) : Gene trapped(59) Radiation induced(1) Targeted(4)
Genomic Mutations involving Lgals1 (1)
Incidental mutations (data from CvDC )
 
Mice homozygous for a knock-out allele exhibit abnormal sensory neurons, altered immune system and delayed muscle development.
 
Phenotype Images(2)
Interactions
Lgals1 interacts with 50 markers (Mir22, Mir27a, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process apoptotic process, heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules, ...
Component cell surface, cytoplasm, ...
Function carbohydrate binding, galactose binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (314)    Tissues (101)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 312
RT-PCR 2
cDNA source data(328)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA LGALS1 ; Xenbase LOC100485378    NEW 
Molecular
reagents
All nucleic(335) Genomic(3) cDNA(329) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000068220 (Evidence)
Entrez Gene 16852 (Evidence)
UniGene 43831
DFCI TC1573420
DoTS DT.101187054, DT.496470, DT.97387089
NIA Mouse Gene Index U016412
PDB 4LBQ
Consensus CDS Project CCDS27628.1
International Mouse Phenotyping Consortium Status Lgals1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16852 NCBI Gene Model | MGI Sequence Detail 3741 C57BL/6J ±  kb
transcript NM_008495 RefSeq | MGI Sequence Detail 817 C57BL/6 
polypeptide P16045 UniProt | EBI | MGI Sequence Detail 135 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR015535 Galectin-1
InterPro IPR001079 Galectin, carbohydrate recognition domain
Protein Ontology PR:000009766 galectin-1
Graphical View of Protein Domain Structure
References
(Earliest) J:113709 Gitt MA, et al., Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes. Proc Natl Acad Sci U S A. 1986 Oct;83(20):7603-7
(Latest) J:216201 Lin YT, et al., Galectin-1 Accelerates Wound Healing by Regulating the Neuropilin-1/Smad3/NOX4 Pathway and ROS Production in Myofibroblasts. J Invest Dermatol. 2015 Jan;135(1):258-68
All references(117)
Other
accession IDs
MGD-MRK-11781, MGD-MRK-11796, MGD-MRK-9961, MGI:2145905

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory