About   Help   FAQ
Lgals1 Gene Detail
Summary
  • Symbol
    Lgals1
  • Name
    lectin, galactose binding, soluble 1
  • Synonyms
    Gal-1, Galbp, galectin-1, L14, Lect14
  • Feature Type
    protein coding gene
  • IDs
    MGI:96777
    NCBI Gene: 16852
  • Gene Overview
    MyGene.info: LGALS1
Location & Maps
more
  • Sequence Map
    Chr15:78926725-78930465 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3741 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.70 cM, cytoband E
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    LGALS1, galectin 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    LGALS1, galectin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GAL1, GBP
  • Links
    NCBI Gene ID: 3956
    neXtProt AC: NX_P09382

  • Chr Location
    22q13.1; chr22:37675606-37679802 (+)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    66
  • Chemically induced (other)
    1
  • Gene trapped
    59
  • Radiation induced
    2
  • Targeted
    4
  • Genomic Mutations
    3 involving Lgals1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit abnormal sensory neurons, altered immune system and delayed muscle development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16852 NCBI Gene Model | MGI Sequence Detail 3741 C57BL/6J ±  kb
transcript NM_008495 RefSeq | MGI Sequence Detail 817 C57BL/6  
polypeptide P16045 UniProt | EBI | MGI Sequence Detail 135 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    43 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009766 galectin-1
  • PDB
  • InterPro Domains
    IPR013320 Concanavalin A-like lectin/glucanase domain
    IPR001079 Galectin, carbohydrate recognition domain
Molecular
Reagents
less
  • All nucleic 335
    Genomic 3
    cDNA 329
    Primer pair 2
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11781, MGD-MRK-11796, MGD-MRK-9961, MGI:2145905
References
more
  • Summaries
    All 120
    Developmental Gene Expression 20
    Diseases 1
    Gene Ontology 9
    Phenotypes 76
  • Earliest
    J:113709 Gitt MA, et al., Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes. Proc Natl Acad Sci U S A. 1986 Oct;83(20):7603-7
  • Latest
    J:223224 Nita-Lazar M, et al., Desialylation of airway epithelial cells during influenza virus infection enhances pneumococcal adhesion via galectin binding. Mol Immunol. 2015 May;65(1):1-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory