| GO term: | plasma cell differentiation |
| Synonym: | plasma cell development |
| GO id: | GO:0002317 |
| Definition: | The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody. |
| Comments | Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. |
| Number of paths to term: | 35 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processsingle-organism cellular processcell activationcell activation involved in immune responseleukocyte activation involved in immune responselymphocyte activation involved in immune responseB cell activation involved in immune responsemature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processcellular processsingle-organism cellular processcell activationleukocyte activationleukocyte activation involved in immune responselymphocyte activation involved in immune responseB cell activation involved in immune responsemature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationB cell activationB cell activation involved in immune responsemature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationB cell activationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationlymphocyte activation involved in immune responseB cell activation involved in immune responsemature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processcellular processsingle-organism cellular processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processdevelopmental processanatomical structure developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processdevelopmental processanatomical structure developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processdevelopmental processanatomical structure developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processdevelopmental processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processdevelopmental processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processdevelopmental processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processdevelopmental processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processimmune system processimmune effector processcell activation involved in immune responseleukocyte activation involved in immune responselymphocyte activation involved in immune responseB cell activation involved in immune responsemature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processimmune system processimmune responsecell activation involved in immune responseleukocyte activation involved in immune responselymphocyte activation involved in immune responseB cell activation involved in immune responsemature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processimmune system processimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processimmune system processleukocyte activationleukocyte activation involved in immune responselymphocyte activation involved in immune responseB cell activation involved in immune responsemature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processimmune system processleukocyte activationlymphocyte activationB cell activationB cell activation involved in immune responsemature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processimmune system processleukocyte activationlymphocyte activationB cell activationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processimmune system processleukocyte activationlymphocyte activationlymphocyte activation involved in immune responseB cell activation involved in immune responsemature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processimmune system processleukocyte activationlymphocyte activationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processresponse to stimulusimmune responsecell activation involved in immune responseleukocyte activation involved in immune responselymphocyte activation involved in immune responseB cell activation involved in immune responsemature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processsingle-organism processsingle-organism cellular processcell activationcell activation involved in immune responseleukocyte activation involved in immune responselymphocyte activation involved in immune responseB cell activation involved in immune responsemature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationleukocyte activation involved in immune responselymphocyte activation involved in immune responseB cell activation involved in immune responsemature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationB cell activationB cell activation involved in immune responsemature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationB cell activationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationlymphocyte activation involved in immune responseB cell activation involved in immune responsemature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processsingle-organism processsingle-organism cellular processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +biological_processsingle-organism processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiationmature B cell differentiationmature B cell differentiation involved in immune responsefollicular B cell differentiationgerminal center B cell differentiationmarginal zone B cell differentiationmemory B cell differentiationplasma cell differentiation [GO:0002317] (3 genes, 3 annotations)negative regulation of plasma cell differentiationpositive regulation of plasma cell differentiationregulation of plasma cell differentiation +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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