Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KISS1
  • Mouse genes Kiss1
  • Rat genes Kiss1
  • Zfish genes kiss1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kiss1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001664	G protein-coupled receptor binding	kiss1	IDA		Zfish	PMID:18509165
Molecular Function	GO:0031773	kisspeptin receptor binding	Kiss1	IPI	RGD:70930	Rat	PMID:11457843|RGD:1357971
Molecular Function	GO:0031773	kisspeptin receptor binding	kiss1	IDA		Zfish	PMID:33301759
Molecular Function	GO:0005515	protein binding	KISS1	IPI	UniProtKB:Q969F8	Human	PMID:11387329
Molecular Function	GO:0005515	protein binding	KISS1	IPI	UniProtKB:Q9UHD9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Kiss1	IPI	PR:Q91V45	Mouse	PMID:12359743
Cellular Component	GO:0016324	apical plasma membrane	Kiss1	IDA		Rat	PMID:17503086|RGD:2292141
Cellular Component	GO:0005737	cytoplasm	Kiss1	IDA		Rat	PMID:17503086|RGD:2292141
Cellular Component	GO:0005615	extracellular space	Kiss1	IDA		Rat	PMID:16339453|RGD:2292147
Cellular Component	GO:0043005	neuron projection	Kiss1	IDA		Rat	PMID:15976058|RGD:2292152
Cellular Component	GO:0043025	neuronal cell body	Kiss1	IDA		Rat	PMID:15976058|RGD:2292152
Biological Process	GO:0046697	decidualization	Kiss1	IMP		Mouse	PMID:24830702
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	Kiss1	IDA		Mouse	PMID:12359743
Biological Process	GO:0060112	generation of ovulation cycle rhythm	Kiss1	IMP		Rat	PMID:15976058|RGD:2292152
Biological Process	GO:0030336	negative regulation of cell migration	Kiss1	IPI	UniProtKB:Q8K3P2	Mouse	PMID:12359743
Biological Process	GO:0008285	negative regulation of cell population proliferation	Kiss1	IPI	UniProtKB:Q8K3P2	Mouse	PMID:12359743
Biological Process	GO:0008285	negative regulation of cell population proliferation	Kiss1	IDA		Rat	PMID:11457843|RGD:1357971
Biological Process	GO:0019228	neuronal action potential	kiss1	IDA		Zfish	PMID:28534042
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	Kiss1	IDA		Rat	PMID:17532794|RGD:2292159
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	Kiss1	IDA		Rat	PMID:11457843|RGD:1357971
Biological Process	GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	Kiss1	IDA		Rat	PMID:16222076|RGD:1599289
Biological Process	GO:0060124	positive regulation of growth hormone secretion	Kiss1	IDA		Rat	PMID:17532794|RGD:2292159
Biological Process	GO:0033686	positive regulation of luteinizing hormone secretion	Kiss1	IMP		Rat	PMID:17213691|RGD:2292143
Biological Process	GO:0033686	positive regulation of luteinizing hormone secretion	Kiss1	IDA		Rat	PMID:17532794|RGD:2292159
Biological Process	GO:0043410	positive regulation of MAPK cascade	Kiss1	IMP		Rat	PMID:16222076|RGD:1599289
Biological Process	GO:0050806	positive regulation of synaptic transmission	Kiss1	IDA		Rat	PMID:16222076|RGD:1599289
Biological Process	GO:1903365	regulation of fear response	kiss1	IDA		Zfish	PMID:25818845

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern