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Kiss1 Gene Detail
Summary
  • Symbol
    Kiss1
  • Name
    KiSS-1 metastasis-suppressor
  • Synonyms
    kisspeptin, metastin
  • Feature Type
    protein coding gene
  • IDs
    MGI:2663985
    NCBI Gene: 280287
  • Gene Overview
    MyGene.info: KISS1
Location & Maps
more
  • Sequence Map
    Chr1:133309827-133329722 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19896 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    KISS1, KiSS-1 metastasis-suppressor
  • Vertebrate Orthologs
    6
  • Human Ortholog
    KISS1, KiSS-1 metastasis-suppressor
    Orthology source: HomoloGene
  • Synonyms
    HH13, KiSS-1
  • Links
    NCBI Gene ID: 3814
    neXtProt AC: NX_Q15726

  • Chr Location
    1q32; chr1:204190341-204196491 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Kiss1 mouse models; 1 with human KISS1 associations

Human Disease Mouse Models
       Hypogonadotropic Hypogonadism 13 with or without Anosmia; HH13   OMIM: 614842 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotypes from multigenic genotypes
    2 images
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    3 involving Kiss1
Homozygote null mice are infertile with abnormal sexual maturation associated with hypogonadotropism
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044883 VEGA Gene Model | MGI Sequence Detail 19896 C57BL/6J ±  kb
transcript OTTMUST00000117937 VEGA | MGI Sequence Detail 624 Not Applicable  
polypeptide OTTMUSP00000065874 VEGA | MGI Sequence Detail 126 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    92 from dbSNP Build 142
Molecular
Reagents
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  • All nucleic 5
    cDNA 4
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 68
    Developmental Gene Expression 9
    Diseases 2
    Gene Ontology 2
    Phenotypes 36
  • Earliest
    J:83519 Stafford LJ, et al., Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res. 2002 Oct 1;62(19):5399-404
  • Latest
    J:226980 Naule L, et al., Delayed pubertal onset and prepubertal Kiss1 expression in female mice lacking central oestrogen receptor beta. Hum Mol Genet. 2015 Dec 20;24(25):7326-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory