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Kiss1
Gene Detail
 Symbol
Name
ID
Kiss1
KiSS-1 metastasis-suppressor
MGI:2663985
Synonyms metastin
Feature Type protein coding gene
Genetic Map
Chromosome 1
57.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:133327212-133329722 bp, + strand
From NCBI annotation of GRCm38

  2511 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1701  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Kiss1

Human
homologs
Human Homolog KISS1, KiSS-1 metastasis-suppressor
NCBI Gene ID 3814
neXtProt AC  NX_Q15726
Human Synonyms  HH13, KiSS-1
Human Chr (Location)  1q32; chr1:204190341-204196491 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KISS1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homozygote null mice are infertile with abnormal sexual maturation associated with hypogonadotropism
 
Human Diseases Modeled Using Mouse Kiss1 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)
Interactions
Kiss1 interacts with 24 markers (Mir25, Mir32, Mir92-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process generation of ovulation cycle rhythm, G-protein coupled receptor signaling pathway, ...
Component apical plasma membrane, cytoplasm, ...
Function G-protein coupled receptor binding, kisspeptin receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (6)    Tissues (3)    Images (1)
Theiler Stages: 20, 25, 27
Assay TypeResults
RT-PCR 6
cDNA source data(4)
External Resources: Allen Institute   GEO  
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000091251 (Evidence)
Entrez Gene280287 (Evidence)
UniGene458301
Consensus CDS ProjectCCDS48362.1
International Mouse Knockout Project StatusKiss1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 280287 NCBI Gene Model | MGI Sequence Detail 2511 C57BL/6J ±  kb
transcript NM_178260 RefSeq | MGI Sequence Detail 496 C57BL/6 
polypeptide NP_839991 RefSeq | MGI Sequence Detail 126 C57BL/6 

For the selected sequences
All sequences(38) RefSeq(18)
Polymorphisms SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000009344 metastasis-suppressor KiSS-1
References (Earliest) J:83519 Stafford LJ, et al., Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res. 2002 Oct 1;62(19):5399-404
(Latest) J:210610 Martin C, et al., Leptin-responsive GABAergic neurons regulate fertility through pathways that result in reduced kisspeptinergic tone. J Neurosci. 2014 Apr 23;34(17):6047-56
All references(48)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory