Kiss1
Gene Detail

Symbol Name ID

Kiss1 KiSS-1 metastasis-suppressor MGI:2663985

Synonyms

metastin

Feature Type

protein coding gene

Genetic Map

Chromosome 1

57.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:133327212-133329722 bp, + strand From NCBI annotation of GRCm38   2511 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1701  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Kiss1

Human homologs

Human Homolog		KISS1, KiSS-1 metastasis-suppressor
NCBI Gene ID		3814
neXtProt AC		NX_Q15726
Human Synonyms		HH13, KiSS-1
Human Chr (Location)		1q32; chr1:204159469-204165619 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KISS1

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygote null mice are infertile with abnormal sexual maturation associated with hypogonadotropism

 
Human Diseases Modeled Using Mouse Kiss1 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	elevation of cytosolic calcium ion concentration, elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway, ...
Component	apical plasma membrane, cytoplasm, ...
Function	G-protein coupled receptor binding, kisspeptin receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (6)    Tissues (3)    Images (1)
Theiler Stages: 20, 25, 28

Assay Type	Results
RT-PCR	6

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000091251 (Evidence)
Entrez Gene	280287 (Evidence)
UniGene	458301
Consensus CDS Project	CCDS48362.1
International Mouse Knockout Project Status	Kiss1

Sequences

Length	Strain/Species
genomic	280287	NCBI Gene Model | MGI Sequence Detail	2511	C57BL/6J
transcript	NM_178260	RefSeq | MGI Sequence Detail	496	C57BL/6
polypeptide	NP_839991	RefSeq | MGI Sequence Detail	126	C57BL/6

All sequences(18) RefSeq(2)

Polymorphisms

SNPs(27 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
Protein Ontology	PR:000009344	metastasis-suppressor KiSS-1

References

(Earliest) J:83519 Stafford LJ, et al., Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res. 2002 Oct 1;62(19):5399-404
(Latest) J:191270 de Croft S, et al., Spontaneous kisspeptin neuron firing in the adult mouse reveals marked sex and brain region differences but no support for a direct role in negative feedback. Endocrinology. 2012 Nov;153(11):5384-93
All references(39)