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Kiss1
Gene Detail
Symbol

Name
ID
Kiss1
KiSS-1 metastasis-suppressor
MGI:2663985
Synonyms
kisspeptin, metastin
Feature Type
protein coding gene
Genetic Map
Chromosome 1
57.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:133309827-133329722 bp, + strand
From VEGA annotation of GRCm38

  19896 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1701  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: KISS1
Gene Tree: Kiss1

Human
homologs
KISS1, KiSS-1 metastasis-suppressor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3814
neXtProt AC: NX_Q15726

Human Synonyms: HH13, KiSS-1

Human Chr (Location): 1q32; chr1:204190341-204196491 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KISS1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homozygote null mice are infertile with abnormal sexual maturation associated with hypogonadotropism
 
Human Diseases Modeled in Mice Using Kiss1 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Kiss1 interacts with 24 markers (Mir25, Mir32, Mir92-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (6)    Tissues (3)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 6
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN kiss1    NEW 
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000044883 (Evidence)
Ensembl Gene Model ENSMUSG00000102367 (Evidence)
Entrez Gene 280287 (Evidence)
UniGene 458301
Consensus CDS Project CCDS48362.1
International Mouse Phenotyping Consortium Status Kiss1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044883 VEGA Gene Model | MGI Sequence Detail 19896 C57BL/6J ±  kb
transcript OTTMUST00000117937 VEGA | MGI Sequence Detail 624 Not Applicable 
polypeptide OTTMUSP00000065874 VEGA | MGI Sequence Detail 126 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(18)
Polymorphisms
SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000009344 metastasis-suppressor KiSS-1
References
(Earliest) J:83519 Stafford LJ, et al., Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res. 2002 Oct 1;62(19):5399-404
(Latest) J:221928 Dubois SL, et al., Positive, but not negative feedback actions of estradiol in adult female mice require estrogen receptor alpha in kisspeptin neurons. Endocrinology. 2015 Mar;156(3):1111-20
All references(61)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory