Comparative GO Graph (mouse, human, rat)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Kcne2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes KCNE2
- Mouse genes Kcne2
- Rat genes Kcne2
- Zfish genes
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Kcne2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	KCNE2	IDA		Human	PMID:10219239
Molecular Function	GO:0005251	delayed rectifier potassium channel activity	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Molecular Function	GO:0042802	identical protein binding	Kcne2	IPI	RGD:621383	Rat	PMID:19913309\|RGD:7243941
Molecular Function	GO:0005242	inward rectifier potassium channel activity	KCNE2	IDA		Human	PMID:10219239
Molecular Function	GO:0005242	inward rectifier potassium channel activity	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Molecular Function	GO:0015459	potassium channel regulator activity	KCNE2	IDA		Human	PMID:10219239
Molecular Function	GO:0015459	potassium channel regulator activity	KCNE2	IDA		Human	PMID:19219384
Molecular Function	GO:0015459	potassium channel regulator activity	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Molecular Function	GO:0015459	potassium channel regulator activity	Kcne2	IDA		Rat	PMID:15292247\|RGD:1580500
Molecular Function	GO:0015459	potassium channel regulator activity	Kcne2	IDA		Rat	PMID:19219384\|RGD:7243947
Molecular Function	GO:0005515	protein binding	KCNE2	IPI	UniProtKB:P51787	Human	PMID:11101505
Molecular Function	GO:0005515	protein binding	KCNE2	IPI	UniProtKB:P51787	Human	PMID:20533308
Molecular Function	GO:0005515	protein binding	Kcne2	IPI	UniProtKB:Q9JKZ2	Mouse	PMID:24595108
Molecular Function	GO:0005515	protein binding	Kcne2	IPI	UniProtKB:P97414	Mouse	PMID:24595108
Molecular Function	GO:0005515	protein binding	Kcne2	IPI	PR:Q61762	Mouse	PMID:18603586
Molecular Function	GO:0005515	protein binding	Kcne2	IPI	PR:Q9Z0V2	Mouse	PMID:18603586
Molecular Function	GO:0005515	protein binding	Kcne2	IPI	RGD:2955	Rat	PMID:14679187\|RGD:7243967
Molecular Function	GO:0005515	protein binding	Kcne2	IPI	RGD:2952	Rat	PMID:21943416\|RGD:7242916
Molecular Function	GO:0044325	transmembrane transporter binding	KCNE2	IDA		Human	PMID:10219239
Molecular Function	GO:0044325	transmembrane transporter binding	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Molecular Function	GO:0044325	transmembrane transporter binding	Kcne2	IPI	UniProtKB:P15387	Rat	PMID:19219384\|RGD:7243947
Molecular Function	GO:0005249	voltage-gated potassium channel activity	Kcne2	IDA		Rat	PMID:15292247\|RGD:1580500
Molecular Function	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization	KCNE2	IMP		Human	PMID:10219239
Cellular Component	GO:0016324	apical plasma membrane	Kcne2	IDA		Mouse	MGI:MGI:6142178\|PMID:24595108
Cellular Component	GO:0009986	cell surface	KCNE2	IDA		Human	PMID:22180649
Cellular Component	GO:0009986	cell surface	Kcne2	IDA		Rat	PMID:21943416\|RGD:7242916
Cellular Component	GO:0005783	endoplasmic reticulum	Kcne2	IDA		Rat	PMID:21943416\|RGD:7242916
Cellular Component	GO:0005794	Golgi apparatus	Kcne2	IDA		Rat	PMID:21943416\|RGD:7242916
Cellular Component	GO:0005764	lysosome	KCNE2	HDA		Human	PMID:16780588
Cellular Component	GO:0016020	membrane	Kcne2	IDA		Mouse	PMID:18603586
Cellular Component	GO:0016020	membrane	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Cellular Component	GO:0005886	plasma membrane	KCNE2	HDA		Human	PMID:16780588
Cellular Component	GO:0005886	plasma membrane	KCNE2	IDA		Human	PMID:19219384
Cellular Component	GO:0005886	plasma membrane	KCNE2	IDA		Human	PMID:20533308
Cellular Component	GO:0005886	plasma membrane	Kcne2	IDA		Rat	PMID:19219384\|RGD:7243947
Cellular Component	GO:0008076	voltage-gated potassium channel complex	KCNE2	IDA		Human	PMID:10219239
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Kcne2	IDA		Mouse	PMID:24595108
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Kcne2	IDA		Rat	PMID:15292247\|RGD:1580500
Cellular Component	GO:0008076	voltage-gated potassium channel complex	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Biological Process	GO:0007568	aging	Kcne2	IEP		Rat	PMID:15066947\|RGD:7243962
Biological Process	GO:0086002	cardiac muscle cell action potential involved in contraction	KCNE2	IMP		Human	PMID:10219239
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	KCNE2	IDA		Human	PMID:10219239
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Biological Process	GO:0051649	establishment of localization in cell	Kcne2	IMP	MGI:MGI:3699589	Mouse	PMID:18603586
Biological Process	GO:0015705	iodide transport	Kcne2	IMP	MGI:MGI:3699589	Mouse	PMID:22549510
Biological Process	GO:0086009	membrane repolarization	KCNE2	IDA		Human	PMID:10219239
Biological Process	GO:0086009	membrane repolarization	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Biological Process	GO:0086011	membrane repolarization during action potential	KCNE2	IMP		Human	PMID:10219239
Biological Process	GO:0086011	membrane repolarization during action potential	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Biological Process	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential	KCNE2	IMP		Human	PMID:10219239
Biological Process	GO:0033555	multicellular organismal response to stress	Kcne2	IMP	MGI:MGI:3699589	Mouse	PMID:24595108
Biological Process	GO:0015798	myo-inositol transport	Kcne2	IMP	MGI:MGI:3699589	Mouse	PMID:24595108
Biological Process	GO:1902260	negative regulation of delayed rectifier potassium channel activity	KCNE2	IDA		Human	PMID:19219384
Biological Process	GO:1902260	negative regulation of delayed rectifier potassium channel activity	Kcne2	IDA		Rat	PMID:19219384\|RGD:7243947
Biological Process	GO:1903817	negative regulation of voltage-gated potassium channel activity	Kcne2	IDA		Rat	PMID:14679187\|RGD:7243967
Biological Process	GO:1903817	negative regulation of voltage-gated potassium channel activity	Kcne2	IDA		Rat	PMID:19219384\|RGD:7243947
Biological Process	GO:1903817	negative regulation of voltage-gated potassium channel activity	Kcne2	IDA		Rat	PMID:21943416\|RGD:7242916
Biological Process	GO:1901800	positive regulation of proteasomal protein catabolic process	KCNE2	IDA		Human	PMID:22180649
Biological Process	GO:1901387	positive regulation of voltage-gated calcium channel activity	Kcne2	IDA		Rat	PMID:14679187\|RGD:7243967
Biological Process	GO:0097623	potassium ion export across plasma membrane	KCNE2	IDA		Human	PMID:10219239
Biological Process	GO:0097623	potassium ion export across plasma membrane	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Biological Process	GO:1990573	potassium ion import across plasma membrane	KCNE2	IMP		Human	PMID:10219239
Biological Process	GO:1990573	potassium ion import across plasma membrane	Kcne2	IMP		Rat	PMID:10219239\|RGD:633041
Biological Process	GO:0071805	potassium ion transmembrane transport	KCNE2	IDA		Human	PMID:10219239
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcne2	IMP	MGI:MGI:3699589	Mouse	PMID:18603586
Biological Process	GO:0071805	potassium ion transmembrane transport	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Biological Process	GO:0008104	protein localization	Kcne2	IMP	MGI:MGI:3699589	Mouse	PMID:18603586
Biological Process	GO:1902159	regulation of cyclic nucleotide-gated ion channel activity	Kcne2	IDA		Rat	PMID:11420311\|RGD:7244388
Biological Process	GO:1902259	regulation of delayed rectifier potassium channel activity	KCNE2	IDA		Human	PMID:10219239
Biological Process	GO:1902259	regulation of delayed rectifier potassium channel activity	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Biological Process	GO:0086091	regulation of heart rate by cardiac conduction	KCNE2	IMP		Human	PMID:10219239
Biological Process	GO:1901979	regulation of inward rectifier potassium channel activity	KCNE2	IDA		Human	PMID:10219239
Biological Process	GO:1901979	regulation of inward rectifier potassium channel activity	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Biological Process	GO:0060306	regulation of membrane repolarization	KCNE2	IDA		Human	PMID:10219239
Biological Process	GO:0060306	regulation of membrane repolarization	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Biological Process	GO:1901379	regulation of potassium ion transmembrane transport	KCNE2	IDA		Human	PMID:10219239
Biological Process	GO:1901379	regulation of potassium ion transmembrane transport	Kcne2	IDA		Rat	PMID:10219239\|RGD:633041
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	KCNE2	IMP		Human	PMID:10219239
Biological Process	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	Kcne2	IMP	MGI:MGI:3699589	Mouse	PMID:18603586
Biological Process	GO:0043586	tongue development	Kcne2	IEP		Rat	PMID:15365256\|RGD:7243961
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	KCNE2	IMP		Human	PMID:10219239
Biological Process	GO:0086005	ventricular cardiac muscle cell action potential	Kcne2	IMP	MGI:MGI:3699589	Mouse	PMID:18603586

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/21/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.