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Kcne2
Gene Detail
 Symbol
Name
ID
Kcne2
potassium voltage-gated channel, Isk-related subfamily, gene 2
MGI:1891123
Synonyms 2200002I16Rik, MiRP1
Feature Type protein coding gene
Genetic Map
Chromosome 16
53.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:92292389-92298129 bp, + strand
From VEGA annotation of GRCm38

  5741 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:71688  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: potassium voltage-gated channel subfamily E member 1
Gene Tree: Kcne2

Human
homologs
Human Homolog KCNE2, potassium voltage-gated channel, Isk-related family, member 2
NCBI Gene ID 9992
neXtProt AC  NX_Q9Y6J6
Human Synonyms  ATFB4, LQT5, LQT6, MIRP1
Human Chr (Location)  21q22.12; chr21:34364024-34371141 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human KCNE2
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Mice homozygous for a knock-out allele exhibit enlarged stomachs, reduced parietal cell proton secretion, abnormal parietal cell morphology, achlorhydria, hypergastrinemia, and gastric glandular hyperplasia due to an increase in the number of non-acid secretory cells.
 
Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process cardiac muscle cell action potential involved in contraction, cellular protein localization, ...
Component cell surface, integral component of membrane, ...
Function delayed rectifier potassium channel activity, inward rectifier potassium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (231)    Tissues (145)    Images (51)
Theiler Stages: 13, 15, 17, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 211
RT-PCR 20
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) cDNA(8) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019966 (Evidence)
Ensembl Gene ModelENSMUSG00000039672 (Evidence)
Entrez Gene246133 (Evidence)
UniGene156736
DFCITC1587351
DoTSDT.50314916, DT.91420424, DT.94271969
NIA Mouse Gene IndexU017390
Consensus CDS ProjectCCDS28333.1
International Mouse Knockout Project StatusKcne2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019966 VEGA Gene Model | MGI Sequence Detail 5741 C57BL/6J ±  kb
transcript OTTMUST00000047581 VEGA | MGI Sequence Detail 1632 Not Applicable 
polypeptide OTTMUSP00000021546 VEGA | MGI Sequence Detail 123 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000369 Potassium channel, voltage-dependent, beta subunit, KCNE
InterPro IPR005424 Potassium channel, voltage-dependent, beta subunit, KCNE1
InterPro IPR005425 Potassium channel, voltage-dependent, beta subunit, KCNE2
Protein Ontology PR:000009256 potassium voltage-gated channel subfamily E member 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(50)
Other
accession IDs
MGI:1916393, MGI:2146614

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory