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Kcne2
Gene Detail
Symbol

Name
ID
Kcne2
potassium voltage-gated channel, Isk-related subfamily, gene 2
MGI:1891123
Synonyms
2200002I16Rik, MiRP1
Feature Type
protein coding gene
Genetic Map
Chromosome 16
53.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:92292389-92298129 bp, + strand
From VEGA annotation of GRCm38

  5741 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:71688  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: KCNE2
Protein SuperFamily: potassium voltage-gated channel subfamily E member 1
Gene Tree: Kcne2

Human
homologs
KCNE2, potassium channel, voltage gated subfamily E regulatory beta subunit 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9992
neXtProt AC: NX_Q9Y6J6

Human Synonyms: ATFB4, LQT5, LQT6, MIRP1

Human Chr (Location): 21q22.12; chr21:34364024-34371141 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human KCNE2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Genomic Mutations involving Kcne2 (5)
 
Mice homozygous for a knock-out allele exhibit enlarged stomachs, reduced parietal cell proton secretion, abnormal parietal cell morphology, achlorhydria, hypergastrinemia, and gastric glandular hyperplasia due to an increase in the number of non-acid secretory cells.
 
Phenotype Images(3)
Interactions
Kcne2 interacts with 170 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Expression
Literature Summary: (12 records)
Data Summary: Results (231)    Tissues (148)    Images (51)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 211
RT-PCR 20
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(8) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000019966 (Evidence)
Ensembl Gene Model ENSMUSG00000039672 (Evidence)
Entrez Gene 246133 (Evidence)
UniGene 156736
DFCI TC1587351
DoTS DT.91420424, DT.94271969, DT.50314916
NIA Mouse Gene Index U017390
Consensus CDS Project CCDS28333.1
International Mouse Phenotyping Consortium Status Kcne2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019966 VEGA Gene Model | MGI Sequence Detail 5741 C57BL/6J ±  kb
transcript OTTMUST00000047580 VEGA | MGI Sequence Detail 1690 Not Applicable 
polypeptide OTTMUSP00000021545 VEGA | MGI Sequence Detail 123 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000369 Potassium channel, voltage-dependent, beta subunit, KCNE
InterPro IPR005424 Potassium channel, voltage-dependent, beta subunit, KCNE1
InterPro IPR005425 Potassium channel, voltage-dependent, beta subunit, KCNE2
Protein Ontology PR:000009256 potassium voltage-gated channel subfamily E member 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(49)
Other
accession IDs
MGI:1916393, MGI:2146614

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory