Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes IRF5
  • Mouse genes Irf5
  • Rat genes Irf5
  • Zfish genes irf5
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Irf5

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IRF5	IDA		Human	PMID:12600985
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IRF5	IDA		Human	PMID:25326418
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Irf5	IDA		Mouse	MGI:MGI:3575850|PMID:15665823
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Irf5	IDA		Mouse	MGI:MGI:5609199|PMID:25326420
Molecular Function	GO:0042802	identical protein binding	IRF5	IPI	UniProtKB:Q13568	Human	PMID:18836453
Molecular Function	GO:0005515	protein binding	IRF5	IPI	UniProtKB:Q92793	Human	PMID:18836453
Molecular Function	GO:0005515	protein binding	IRF5	IPI	UniProtKB:Q04206	Human	PMID:20237317
Molecular Function	GO:0005515	protein binding	IRF5	IPI	UniProtKB:Q7Z434	Human	PMID:21903422
Molecular Function	GO:0005515	protein binding	IRF5	IPI	UniProtKB:O43765	Human	PMID:21988832
Molecular Function	GO:0005515	protein binding	IRF5	IPI	UniProtKB:Q9HAI6	Human	PMID:32433612
Molecular Function	GO:0005515	protein binding	Irf5	IPI	PR:P22366	Mouse	PMID:16236719
Molecular Function	GO:0019901	protein kinase binding	IRF5	IPI	UniProtKB:O14920	Human	PMID:25326418
Molecular Function	GO:0019901	protein kinase binding	Irf5	IPI	UniProtKB:O88351	Mouse	MGI:MGI:5609199|PMID:25326420
Molecular Function	GO:0043565	sequence-specific DNA binding	IRF5	IMP		Human	PMID:23332764
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	IRF5	IDA		Human	PMID:28473536
Cellular Component	GO:0005737	cytoplasm	IRF5	IDA		Human	PMID:22412986
Cellular Component	GO:0005737	cytoplasm	IRF5	IDA		Human	PMID:25326418
Cellular Component	GO:0005737	cytoplasm	Irf5	IDA		Mouse	MGI:MGI:5609199|PMID:25326420
Cellular Component	GO:0005737	cytoplasm	Irf5	IDA		Mouse	MGI:MGI:3575850|PMID:15665823
Cellular Component	GO:0005737	cytoplasm	Irf5	IDA		Rat	PMID:21737101|RGD:10402168
Cellular Component	GO:0005634	nucleus	IRF5	IDA		Human	PMID:22412986
Cellular Component	GO:0005634	nucleus	IRF5	IDA		Human	PMID:25326418
Cellular Component	GO:0005634	nucleus	Irf5	IDA		Mouse	MGI:MGI:3575850|PMID:15665823
Cellular Component	GO:0005634	nucleus	Irf5	IDA		Mouse	MGI:MGI:5609199|PMID:25326420
Cellular Component	GO:0005634	nucleus	Irf5	IDA		Rat	PMID:21737101|RGD:10402168
Cellular Component	GO:0005634	nucleus	Irf5	IDA		Rat	PMID:31177020|RGD:40924651
Biological Process	GO:0019221	cytokine-mediated signaling pathway	IRF5	IDA		Human	PMID:25326418
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Irf5	IDA		Mouse	MGI:MGI:5609199|PMID:25326420
Biological Process	GO:0019221	cytokine-mediated signaling pathway	Irf5	IDA		Mouse	MGI:MGI:3575850|PMID:15665823
Biological Process	GO:0051607	defense response to virus	Irf5	IMP		Mouse	MGI:MGI:4881394|PMID:20451243
Biological Process	GO:0045087	innate immune response	Irf5	IDA		Mouse	MGI:MGI:3575850|PMID:15665823
Biological Process	GO:0043065	positive regulation of apoptotic process	IRF5	IMP		Human	PMID:22412986
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF5	IDA		Human	PMID:12600985
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF5	IDA		Human	PMID:22412986
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF5	IDA		Human	PMID:25326418
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IRF5	IDA		Human	PMID:32433612
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Irf5	IDA		Mouse	MGI:MGI:3575850|PMID:15665823
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Irf5	IDA		Mouse	MGI:MGI:5609199|PMID:25326420
Biological Process	GO:0032481	positive regulation of type I interferon production	IRF5	IDA		Human	PMID:32433612
Biological Process	GO:0032495	response to muramyl dipeptide	IRF5	IDA		Human	PMID:22412986
Biological Process	GO:0032494	response to peptidoglycan	IRF5	IDA		Human	PMID:22412986

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern