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Irf5
Gene Detail
 Symbol
Name
ID
Irf5
interferon regulatory factor 5
MGI:1350924
Synonyms mirf5
Feature Type protein coding gene
Genetic Map
Chromosome 6
12.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:29526625-29541869 bp, + strand
From VEGA annotation of GRCm38

  15245 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8088  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf5

Human
homologs
Human Homolog IRF5, interferon regulatory factor 5
NCBI Gene ID 3663
neXtProt AC  NX_Q13568
Human Synonyms  SLEB10
Human Chr (Location)  7q32; chr7:128937940-128950035 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human IRF5
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit resistance to lethal shock with a marked decrease in the serum levels of proinflammatory cytokines, but normal B cell development. Mice homozygous for another allele are viable and fertile.
 
Interactions
Irf5 interacts with 84 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process defense response to virus, immune system process, ...
Component cytoplasm, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (55)    Tissues (53)    Images (6)
Theiler Stages: 15, 17, 18, 21, 23, 28
Assay TypeResults
RNA in situ 55
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(33) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035855 (Evidence)
Ensembl Gene ModelENSMUSG00000029771 (Evidence)
Entrez Gene27056 (Evidence)
UniGene6479
DFCITC1576987
DoTSDT.101384141, DT.97373623, DT.97411844
NIA Mouse Gene IndexU006617
Consensus CDS ProjectCCDS19962.1
International Mouse Knockout Project StatusIrf5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035855 VEGA Gene Model | MGI Sequence Detail 15245 C57BL/6J ±  kb
transcript OTTMUST00000091896 VEGA | MGI Sequence Detail 2241 Not Applicable 
polypeptide OTTMUSP00000050675 VEGA | MGI Sequence Detail 497 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(18) UniProt(5)
Polymorphisms SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019471 Interferon regulatory factor-3
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000002047 interferon regulatory factor 5
References (Earliest) J:61896 Lee YJ, et al., Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett. 2000 Apr 28;472(2-3):230-4
(Latest) J:207307 Lebel ME, et al., Nanoparticle adjuvant sensing by TLR7 enhances CD8+ T cell-mediated protection from Listeria monocytogenes infection. J Immunol. 2014 Feb 1;192(3):1071-8
All references(71)
Other
accession IDs
MGI:2141682

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory