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Irf5 Gene Detail
Summary
  • Symbol
    Irf5
  • Name
    interferon regulatory factor 5
  • Synonyms
    mirf5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1350924
    NCBI Gene: 27056
Location & Maps
more
  • Sequence Map
    Chr6:29526625-29541871 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15247 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IRF5, interferon regulatory factor 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    IRF5, interferon regulatory factor 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SLEB10
  • Links
    NCBI Gene ID: 3663
    neXtProt AC: NX_Q13568

  • Chr Location
    7q32; chr7:128937737-128950042 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human IRF5 associations

Human Disease Mouse Models
       Inflammatory Bowel Disease 14; IBD14   OMIM: 612245
Systemic Lupus Erythematosus, Susceptibility to, 10; SLEB10   OMIM: 612251
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit resistance to lethal shock with a marked decrease in the serum levels of proinflammatory cytokines, but normal B cell development. Mice homozygous for another allele are viable and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035855 VEGA Gene Model | MGI Sequence Detail 15247 C57BL/6J ±  kb
transcript OTTMUST00000091864 VEGA | MGI Sequence Detail 2189 Not Applicable  
polypeptide OTTMUSP00000050648 VEGA | MGI Sequence Detail 497 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    45 from dbSNP Build 137
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000002047 interferon regulatory factor 5
  • InterPro Domains
    IPR019471 Interferon regulatory factor-3
    IPR029838 Interferon regulatory factor 5
    IPR019817 Interferon regulatory factor, conserved site
    IPR001346 Interferon regulatory factor DNA-binding domain
    IPR017855 SMAD domain-like
    IPR008984 SMAD/FHA domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 34
    cDNA 33
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2141682
References
more
  • Summaries
    All 70
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 37
  • Earliest
    J:61896 Lee YJ, et al., Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett. 2000 Apr 28;472(2-3):230-4
  • Latest
    J:226709 Weiss M, et al., IRF5 controls both acute and chronic inflammation. Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11001-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory