Irf5
Gene Detail

Symbol Name ID

Irf5 interferon regulatory factor 5 MGI:1350924

Synonyms

mirf5

Feature Type

protein coding gene

Genetic Map

Chromosome 6

12.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:29526625-29541869 bp, + strand From VEGA annotation of GRCm38   15245 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8088  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf5

Human homologs

Human Homolog		IRF5, interferon regulatory factor 5
NCBI Gene ID		3663
neXtProt AC		NX_Q13568
Human Synonyms		SLEB10
Human Chr (Location)		7q32; chr7:128577994-128590089 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human IRF5

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice exhibit resistance to lethal shock with a marked decrease in the serum levels of proinflammatory cytokines, but normal B cell development. Mice homozygous for another allele are viable and fertile.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	defense response to virus, innate immune response, ...
Component	cytoplasm, nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (55)    Tissues (53)    Images (6)
Theiler Stages: 15, 17, 18, 21, 23, 28

Assay Type	Results
RNA in situ	55

cDNA source data(35)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) cDNA(36) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035855 (Evidence)
Ensembl Gene Model	ENSMUSG00000029771 (Evidence)
Entrez Gene	27056 (Evidence)
UniGene	6479
DFCI	TC1576987
DoTS	DT.101384141, DT.97373623, DT.97411844
NIA Mouse Gene Index	U006617
Consensus CDS Project	CCDS19962.1
International Mouse Knockout Project Status	Irf5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035855	VEGA Gene Model | MGI Sequence Detail	15245	C57BL/6J
transcript	OTTMUST00000091864	VEGA | MGI Sequence Detail	2189	Not Applicable
polypeptide	OTTMUSP00000050648	VEGA | MGI Sequence Detail	497	Not Applicable

All sequences(49) RefSeq(4) UniProt(5)

Polymorphisms

SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019471	Interferon regulatory factor-3
InterPro	IPR019817	Interferon regulatory factor, conserved site
InterPro	IPR001346	Interferon regulatory factor DNA-binding domain
InterPro	IPR017855	SMAD domain-like
InterPro	IPR008984	SMAD/FHA domain
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000002047	interferon regulatory factor 5

References

(Earliest) J:61896 Lee YJ, et al., Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett. 2000 Apr 28;472(2-3):230-4
(Latest) J:188158 Panchanathan R, et al., Murine BAFF expression is up-regulated by estrogen and interferons: Implications for sex bias in the development of autoimmunity. Mol Immunol. 2013 Jan;53(1-2):15-23
All references(66)

Other accession IDs

MGI:2141682