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Irf5
Gene Detail
Symbol

Name
ID
Irf5
interferon regulatory factor 5
MGI:1350924
Synonyms
mirf5
Feature Type
protein coding gene
Genetic Map
Chromosome 6
12.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:29526625-29541871 bp, + strand
From VEGA annotation of GRCm38

  15247 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8088  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: IRF5
Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf5

Human
homologs
IRF5, interferon regulatory factor 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3663
neXtProt AC: NX_Q13568

Human Synonyms: SLEB10

Human Chr (Location): 7q32; chr7:128937737-128950042 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human IRF5

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit resistance to lethal shock with a marked decrease in the serum levels of proinflammatory cytokines, but normal B cell development. Mice homozygous for another allele are viable and fertile.
 
Interactions
Irf5 interacts with 84 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cytokine-mediated signaling pathway, defense response to virus, ...
Component cytoplasm, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (55)    Tissues (53)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase irf5 ; ZFIN irf5    NEW 
Molecular
reagents
All nucleic(34) cDNA(33) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035855 (Evidence)
Ensembl Gene Model ENSMUSG00000029771 (Evidence)
Entrez Gene 27056 (Evidence)
UniGene 6479
DFCI TC1576987
DoTS DT.101384141, DT.97373623, DT.97411844
NIA Mouse Gene Index U006617
Consensus CDS Project CCDS19962.1, CCDS80504.1
International Mouse Phenotyping Consortium Status Irf5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035855 VEGA Gene Model | MGI Sequence Detail 15247 C57BL/6J ±  kb
transcript OTTMUST00000091864 VEGA | MGI Sequence Detail 2189 Not Applicable 
polypeptide OTTMUSP00000050648 VEGA | MGI Sequence Detail 497 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(16) UniProt(5)
Polymorphisms
SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019471 Interferon regulatory factor-3
InterPro IPR029838 Interferon regulatory factor 5
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000002047 interferon regulatory factor 5
References
(Earliest) J:61896 Lee YJ, et al., Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett. 2000 Apr 28;472(2-3):230-4
(Latest) J:218999 Yasuda K, et al., Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2. PLoS One. 2014;9(7):e103478
All references(72)
Other
accession IDs
MGI:2141682

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory