Irf5 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Irf5
interferon regulatory factor 5
MGI:1350924

14 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Irf5^em1(IMPC)Bay/Irf5^em1(IMPC)Bay C57BL/6N-Irf5^em1(IMPC)Bay/BayMmucd	preweaning lethality, complete penetrance	J:211773
Irf5^{tm1e(EUCOMM)Wtsi}/Irf5^{tm1e(EUCOMM)Wtsi} C57BL/6N-Irf5^{tm1e(EUCOMM)Wtsi}/Wtsi	decreased CD4-positive, alpha-beta memory T cell number	J:211773
	decreased leukocyte cell number	J:211773
Irf5^tm1Ppr/Irf5^tm1Ppr involves: C57BL/6	no abnormal phenotype detected	J:176418
Irf5^tm1Ttg/Irf5^tm1Ttg B6.129P2-Irf5^tm1Ttg	abnormal response to infection	J:182658
	decreased interferon-alpha secretion	J:182658
	decreased interleukin-6 secretion	J:182658
	decreased tumor necrosis factor secretion	J:182658
	normal immune system phenotype	J:182658
Irf5^tm1Ttg/Irf5^tm1Ttg involves: 129P2/OlaHsd * C57BL/6	abnormal T-helper 1 physiology	J:97567
	decreased circulating interleukin-6 level	J:97567
	decreased circulating interleukin-12b level	J:97567
	decreased circulating tumor necrosis factor level	J:97567
	decreased susceptibility to bacterial infection	J:97567
	normal immune system phenotype	J:182658

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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