Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Igf2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes IGF2
- Mouse genes Igf2
- Rat genes Igf2
- Zfish genes igf2a,igf2b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Igf2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008083	growth factor activity	IGF2	IDA		Human	PMID:11500939
Molecular Function	GO:0005158	insulin receptor binding	IGF2	IPI	UniProtKB:P06213	Human	PMID:12138094
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	IGF2	IMP		Human	PMID:2967174
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	Igf2	IPI	PR:Q07113	Mouse	PMID:14566968
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	igf2b	IDA		Zfish	PMID:19759899
Molecular Function	GO:0005159	insulin-like growth factor receptor binding	igf2a	IDA		Zfish	PMID:19759899
Molecular Function	GO:0005178	integrin binding	IGF2	IDA		Human	PMID:28873464
Molecular Function	GO:0005515	protein binding	IGF2	IPI	UniProtKB:Q9PTH3	Human	PMID:10611375
Molecular Function	GO:0005515	protein binding	IGF2	IPI	UniProtKB:P11717	Human	PMID:18046459
Molecular Function	GO:0005515	protein binding	IGF2	IPI	UniProtKB:Q93062	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	Igf2	IPI	PR:Q69ZQ1	Mouse	PMID:19706595
Molecular Function	GO:0005515	protein binding	Igf2	IPI	PR:Q07079	Mouse	PMID:14566968
Molecular Function	GO:0005515	protein binding	Igf2	IPI	UniProtKB:P12843	Rat	PMID:2538475\|RGD:729148
Molecular Function	GO:0005515	protein binding	Igf2	IPI	UniProtKB:P12843	Rat	PMID:2974285\|RGD:8553840
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	Igf2	IMP		Mouse	MGI:MGI:4438697\|PMID:20032056
Molecular Function	GO:0048018	receptor ligand activity	Igf2	IMP		Mouse	MGI:MGI:4438697\|PMID:20032056
Molecular Function	GO:0048018	receptor ligand activity	Igf2	IGI	MGI:MGI:96433	Mouse	PMID:9281335
Molecular Function	GO:0048018	receptor ligand activity	Igf2	IDA		Mouse	PMID:29348399
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Igf2	IGI	MGI:MGI:96433	Mouse	PMID:9281335
Molecular Function	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity	Igf2	IDA		Mouse	PMID:29348399
Cellular Component	GO:0062023	collagen-containing extracellular matrix	Igf2	HDA		Mouse	MGI:MGI:6201853\|PMID:28071719
Cellular Component	GO:0005615	extracellular space	Igf2	IDA		Mouse	PMID:18762576
Cellular Component	GO:0005615	extracellular space	Igf2	IDA		Rat	PMID:6390212\|RGD:1624322
Biological Process	GO:0009887	animal organ morphogenesis	Igf2	IMP	MGI:MGI:2677156	Mouse	PMID:12101187
Biological Process	GO:0071260	cellular response to mechanical stimulus	Igf2	IEP		Rat	PMID:20695079\|RGD:5509947
Biological Process	GO:0001892	embryonic placenta development	Igf2	IMP		Mouse	MGI:MGI:2181513\|PMID:12087403
Biological Process	GO:0060669	embryonic placenta morphogenesis	Igf2	IMP		Mouse	MGI:MGI:5908476\|PMID:28522536
Biological Process	GO:0031017	exocrine pancreas development	Igf2	IMP	MGI:MGI:2677156	Mouse	PMID:12101187
Biological Process	GO:0007565	female pregnancy	Igf2	IEP		Rat	PMID:19776249\|RGD:5509949
Biological Process	GO:0031101	fin regeneration	igf2b	IMP	ZFIN:ZDB-MRPHLNO-100601-1	Zfish	PMID:20179093
Biological Process	GO:0030900	forebrain development	igf2b	IMP	ZFIN:ZDB-MRPHLNO-090929-3,ZFIN:ZDB-MRPHLNO-090929-4	Zfish	PMID:19443571
Biological Process	GO:0001701	in utero embryonic development	Igf2	IMP		Mouse	MGI:MGI:5908476\|PMID:28522536
Biological Process	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase	Igf2	IMP		Mouse	MGI:MGI:4438697\|PMID:20032056
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Igf2	IGI	MGI:MGI:96433	Mouse	PMID:9281335
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Igf2	IDA		Mouse	PMID:29348399
Biological Process	GO:0007613	memory	Igf2	IMP		Rat	PMID:21270887\|RGD:5509946
Biological Process	GO:0051148	negative regulation of muscle cell differentiation	Igf2	IMP		Mouse	MGI:MGI:6467708\|PMID:32557799
Biological Process	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity	Igf2	IDA		Rat	PMID:9021955\|RGD:9685777
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Igf2	IMP		Mouse	MGI:MGI:5908341\|PMID:16901893
Biological Process	GO:0030903	notochord development	igf2b	IMP	ZFIN:ZDB-MRPHLNO-090929-3,ZFIN:ZDB-MRPHLNO-090929-4	Zfish	PMID:19443571
Biological Process	GO:0030903	notochord development	igf2b	IGI	ZFIN:ZDB-MRPHLNO-090929-1,ZFIN:ZDB-MRPHLNO-090929-2,ZFIN:ZDB-MRPHLNO-090929-3,ZFIN:ZDB-MRPHLNO-090929-4	Zfish	PMID:19443571
Biological Process	GO:0030903	notochord development	igf2a	IGI	ZFIN:ZDB-MRPHLNO-090929-1,ZFIN:ZDB-MRPHLNO-090929-2,ZFIN:ZDB-MRPHLNO-090929-3,ZFIN:ZDB-MRPHLNO-090929-4	Zfish	PMID:19443571
Biological Process	GO:0030903	notochord development	igf2a	IMP	ZFIN:ZDB-MRPHLNO-090929-1,ZFIN:ZDB-MRPHLNO-090929-2	Zfish	PMID:19443571
Biological Process	GO:0001649	osteoblast differentiation	Igf2	IEP		Mouse	MGI:MGI:3828402\|PMID:16311053
Biological Process	GO:0042104	positive regulation of activated T cell proliferation	IGF2	IDA		Human	PMID:15694994
Biological Process	GO:0045766	positive regulation of angiogenesis	Igf2	IGI	RNAcentral:URS00004DE9D7_10116	Rat	PMID:28735866\|RGD:13506264
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	Igf2	IGI	RNAcentral:URS00004DE9D7_10116	Rat	PMID:28735866\|RGD:13506264
Biological Process	GO:0043085	positive regulation of catalytic activity	Igf2	IMP		Mouse	MGI:MGI:4438697\|PMID:20032056
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGF2	IDA		Human	PMID:28873464
Biological Process	GO:2000467	positive regulation of glycogen (starch) synthase activity	Igf2	IMP		Mouse	MGI:MGI:4438697\|PMID:20032056
Biological Process	GO:0045725	positive regulation of glycogen biosynthetic process	Igf2	IMP		Mouse	MGI:MGI:4438697\|PMID:20032056
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	IGF2	IDA		Human	PMID:11500939
Biological Process	GO:0046628	positive regulation of insulin receptor signaling pathway	Igf2	IMP		Mouse	MGI:MGI:4438697\|PMID:20032056
Biological Process	GO:0043410	positive regulation of MAPK cascade	IGF2	IDA		Human	PMID:11500939
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	IGF2	IDA		Human	PMID:11500939
Biological Process	GO:0040018	positive regulation of multicellular organism growth	Igf2	IMP		Mouse	PMID:9203585
Biological Process	GO:0046622	positive regulation of organ growth	Igf2	IMP		Mouse	MGI:MGI:6120647\|PMID:29440408
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Igf2	IMP		Mouse	MGI:MGI:4438697\|PMID:20032056
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IGF2	IDA		Human	PMID:11500939
Biological Process	GO:0001934	positive regulation of protein phosphorylation	Igf2	IMP		Mouse	MGI:MGI:4438697\|PMID:20032056
Biological Process	GO:0048633	positive regulation of skeletal muscle tissue growth	Igf2	IMP		Mouse	MGI:MGI:6120647\|PMID:29440408
Biological Process	GO:0090031	positive regulation of steroid hormone biosynthetic process	Igf2	IDA		Rat	PMID:17023532\|RGD:1600072
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Igf2	IGI	MGI:MGI:87986	Mouse	PMID:18762576
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	Igf2	IGI	RNAcentral:URS00004DE9D7_10116	Rat	PMID:28735866\|RGD:13506264
Biological Process	GO:0048793	pronephros development	igf2b	IMP	ZFIN:ZDB-MRPHLNO-090929-3,ZFIN:ZDB-MRPHLNO-090929-4	Zfish	PMID:19443571
Biological Process	GO:0051147	regulation of muscle cell differentiation	Igf2	IMP		Mouse	MGI:MGI:5908341\|PMID:16901893
Biological Process	GO:0032355	response to estradiol	Igf2	IEP		Rat	PMID:18946176\|RGD:2311518
Biological Process	GO:0045471	response to ethanol	Igf2	IEP		Rat	PMID:18505416\|RGD:5510002
Biological Process	GO:0035094	response to nicotine	Igf2	IDA		Rat	PMID:19494366\|RGD:5509950
Biological Process	GO:0035094	response to nicotine	Igf2	IEP		Rat	PMID:19494366\|RGD:5509950
Biological Process	GO:0031667	response to nutrient levels	Igf2	IEP		Rat	PMID:17626604\|RGD:2311522
Biological Process	GO:0014070	response to organic cyclic compound	Igf2	IDA		Rat	PMID:17407073\|RGD:2311525
Biological Process	GO:0009314	response to radiation	Igf2	IEP		Rat	PMID:17630476\|RGD:2311521
Biological Process	GO:0009410	response to xenobiotic stimulus	Igf2	IDA		Rat	PMID:18778817\|RGD:5509951
Biological Process	GO:0001756	somitogenesis	igf2b	IMP	ZFIN:ZDB-MRPHLNO-090929-3,ZFIN:ZDB-MRPHLNO-090929-4	Zfish	PMID:19443571
Biological Process	GO:0001756	somitogenesis	igf2b	IGI	ZFIN:ZDB-MRPHLNO-090929-1,ZFIN:ZDB-MRPHLNO-090929-2,ZFIN:ZDB-MRPHLNO-090929-3,ZFIN:ZDB-MRPHLNO-090929-4	Zfish	PMID:19443571
Biological Process	GO:0001756	somitogenesis	igf2a	IMP	ZFIN:ZDB-MRPHLNO-090929-1,ZFIN:ZDB-MRPHLNO-090929-2	Zfish	PMID:19443571
Biological Process	GO:0001756	somitogenesis	igf2a	IGI	ZFIN:ZDB-MRPHLNO-090929-1,ZFIN:ZDB-MRPHLNO-090929-2,ZFIN:ZDB-MRPHLNO-090929-3,ZFIN:ZDB-MRPHLNO-090929-4	Zfish	PMID:19443571
Biological Process	GO:0060720	spongiotrophoblast cell proliferation	Igf2	IMP		Mouse	MGI:MGI:5424276\|PMID:22562201
Biological Process	GO:0002040	sprouting angiogenesis	igf2b	IMP	ZFIN:ZDB-MRPHLNO-090929-4,ZFIN:ZDB-MRPHLNO-100527-1	Zfish	PMID:29951828
Biological Process	GO:0002040	sprouting angiogenesis	igf2a	IMP	ZFIN:ZDB-MRPHLNO-090929-1,ZFIN:ZDB-MRPHLNO-090929-2	Zfish	PMID:29951828
Biological Process	GO:0051146	striated muscle cell differentiation	Igf2	IGI	MGI:MGI:96440	Mouse	PMID:18762576
Biological Process	GO:0042060	wound healing	Igf2	IEP		Rat	PMID:7770004\|RGD:5509999

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.