Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HTR1B
  • Mouse genes Htr1b
  • Rat genes Htr1b
  • Zfish genes htr1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Htr1b

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	HTR1B	IDA		Human	PMID:1315531
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr1b	IDA		Mouse	MGI:MGI:4821070|PMID:17325130
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr1b	IDA		Mouse	MGI:MGI:64075
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr1b	IDA		Rat	PMID:15328035|RGD:1358659
Molecular Function	GO:1901363	heterocyclic compound binding	Htr1b	IDA		Rat	PMID:16546225|RGD:1626467
Molecular Function	GO:0005515	protein binding	HTR1B	IPI	UniProtKB:Q99750	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	HTR1B	IPI	UniProtKB:Q99750	Human	PMID:25416956
Molecular Function	GO:0005515	protein binding	HTR1B	IPI	UniProtKB:Q99750	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	HTR1B	IPI	UniProtKB:P35609	Human	PMID:32296183
Molecular Function	GO:0051378	serotonin binding	Htr1b	IDA		Mouse	MGI:MGI:4821070|PMID:17325130
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	Htr1b	EXP		Rat	PMID:17067296|RGD:13702319
Molecular Function	GO:0099626	voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	Htr1b	IDA		Rat	PMID:17067296|RGD:13702319
Cellular Component	GO:0044305	calyx of Held	Htr1b	EXP		Rat	PMID:17067296|RGD:13702319
Cellular Component	GO:0044305	calyx of Held	Htr1b	IDA		Rat	PMID:17067296|RGD:13702319
Cellular Component	GO:0005737	cytoplasm	Htr1b	IDA		Mouse	MGI:MGI:4821070|PMID:17325130
Cellular Component	GO:0005783	endoplasmic reticulum	HTR1B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	Htr1b	IDA		Mouse	MGI:MGI:4821070|PMID:17325130
Cellular Component	GO:0005886	plasma membrane	HTR1B	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005886	plasma membrane	HTR1B	IMP		Human	PMID:1315531
Cellular Component	GO:0005886	plasma membrane	Htr1b	IDA		Mouse	MGI:MGI:4821070|PMID:17325130
Cellular Component	GO:0005886	plasma membrane	Htr1b	IDA		Rat	PMID:15328035|RGD:1358659
Cellular Component	GO:0042734	presynaptic membrane	Htr1b	IDA		Mouse	PMID:10234032
Cellular Component	GO:0099154	serotonergic synapse	Htr1b	IDA		Mouse	PMID:10234032
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	HTR1B	IDA		Human	PMID:8882600
Biological Process	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	Htr1b	IDA		Mouse	MGI:MGI:64075
Biological Process	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	HTR1B	IDA		Human	PMID:1315531
Biological Process	GO:0046849	bone remodeling	Htr1b	IGI	MGI:MGI:98796	Mouse	PMID:19041748
Biological Process	GO:0046849	bone remodeling	Htr1b	IGI	MGI:MGI:1278315	Mouse	PMID:19041748
Biological Process	GO:0071312	cellular response to alkaloid	HTR1B	IDA		Human	PMID:1315531
Biological Process	GO:0071502	cellular response to temperature stimulus	Htr1b	IDA		Mouse	MGI:MGI:4821070|PMID:17325130
Biological Process	GO:0071466	cellular response to xenobiotic stimulus	HTR1B	IDA		Human	PMID:1315531
Biological Process	GO:0007268	chemical synaptic transmission	Htr1b	IDA		Rat	PMID:15328035|RGD:1358659
Biological Process	GO:0042756	drinking behavior	Htr1b	IMP		Rat	PMID:16839853|RGD:1626464
Biological Process	GO:0007631	feeding behavior	Htr1b	IMP		Rat	PMID:12373419|RGD:1626446
Biological Process	GO:0002031	G protein-coupled receptor internalization	Htr1b	IDA		Mouse	MGI:MGI:4821070|PMID:17325130
Biological Process	GO:0014053	negative regulation of gamma-aminobutyric acid secretion	Htr1b	IDA		Rat	PMID:30217553|RGD:15023474
Biological Process	GO:0014063	negative regulation of serotonin secretion	Htr1b	IMP		Mouse	MGI:MGI:1098377|PMID:9349547
Biological Process	GO:0032229	negative regulation of synaptic transmission, GABAergic	Htr1b	IMP		Rat	PMID:17229091|RGD:1626455
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	Htr1b	IMP		Rat	PMID:17392733|RGD:1626454
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	HTR1B	IMP		Human	PMID:25871906
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Htr1b	EXP		Rat	PMID:17067296|RGD:13702319
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Htr1b	IDA		Rat	PMID:17067296|RGD:13702319
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	Htr1b	IMP		Mouse	MGI:MGI:4821070|PMID:17325130
Biological Process	GO:0014059	regulation of dopamine secretion	Htr1b	IMP		Rat	PMID:16885935|RGD:1626459
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Htr1b	EXP		Rat	PMID:17067296|RGD:13702319
Biological Process	GO:2000300	regulation of synaptic vesicle exocytosis	Htr1b	IDA		Rat	PMID:17067296|RGD:13702319
Biological Process	GO:0042220	response to cocaine	Htr1b	IDA		Rat	PMID:17509084|RGD:1626452
Biological Process	GO:0045471	response to ethanol	Htr1b	IMP		Rat	PMID:16212943|RGD:1626469
Biological Process	GO:0051385	response to mineralocorticoid	Htr1b	IEP		Rat	PMID:11882579|RGD:1626447
Biological Process	GO:0009636	response to toxic substance	Htr1b	IDA		Mouse	MGI:MGI:64075

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern