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Htr1b Gene Detail
Summary
  • Symbol
    Htr1b
  • Name
    5-hydroxytryptamine (serotonin) receptor 1B
  • Synonyms
    5-HT1B receptor, 5-HT1B receptor, 5HT1B receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96274
    NCBI Gene: 15551
  • Gene Overview
    MyGene.info: HTR1B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:81628291-81633828 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5538 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 44.61 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    HTR1B, 5-hydroxytryptamine receptor 1B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HTR1B, 5-hydroxytryptamine receptor 1B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    5-HT1B, 5-HT-1B, 5-HT1DB, 5-HT-1D-beta, HTR1D2, HTR1DB, S12
  • Links
    NCBI Gene ID: 3351
    neXtProt AC: NX_P28222
    UniProt: P28222

  • Chr Location
    6q14.1; chr6:77460848-77464022 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit an increase in body weight, aggression, drinking behavior, and osteoblast proliferation and bone mass, and show altered spatial learning and operant conditional behavior as well as reduced anxiety-related response and startle reflex, and small testes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000044868 VEGA Gene Model | MGI Sequence Detail 5538 C57BL/6J ±  kb
    transcript OTTMUST00000117899 VEGA | MGI Sequence Detail 4724 Not Applicable  
    polypeptide OTTMUSP00000065857 VEGA | MGI Sequence Detail 386 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      93 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 1
      cDNA 4
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11000
    References
    more
    • Summaries
      All 139
      Developmental Gene Expression 12
      Gene Ontology 10
      Phenotypes 68
    • Earliest
      J:43 Maroteaux L, et al., Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3020-4
    • Latest
      J:256106 Medrihan L, et al., Initiation of Behavioral Response to Antidepressants by Cholecystokinin Neurons of the Dentate Gyrus. Neuron. 2017 Aug 2;95(3):564-576.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory