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Htr1b
Gene Detail
Symbol

Name
ID
Htr1b
5-hydroxytryptamine (serotonin) receptor 1B
MGI:96274
Synonyms
5-HT1B receptor, 5-HT1B receptor, 5HT1B receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 9
44.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr9:81628291-81633828 bp, - strand
From VEGA annotation of GRCm38

  5538 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:669  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HTR1B
Protein SuperFamily: 5-hydroxytryptamine receptor 1
Gene Tree: Htr1b

Human
homologs
HTR1B, 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3351
neXtProt AC: NX_P28222

Human Synonyms: 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12

Human Chr (Location): 6q13; chr6:77462231-77463403 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit an increase in body weight, aggression, drinking behavior, and osteoblast proliferation and bone mass, and show altered spatial learning and operant conditional behavior as well as reduced anxiety-related response and startle reflex, and small testes.
 
Interactions
Htr1b interacts with 10 markers (Mir133a-1, Mir133a-2, Mir133b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (71)    Tissues (65)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
RT-PCR 46
cDNA source data(3)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) Genomic(1) cDNA(3) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000044868 (Evidence)
Ensembl Gene Model ENSMUSG00000049511 (Evidence)
Entrez Gene 15551 (Evidence)
UniGene 445308
DFCI TC1735752
DoTS DT.91316076
NIA Mouse Gene Index U069366
Consensus CDS Project CCDS23370.1
International Mouse Phenotyping Consortium Status Htr1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044868 VEGA Gene Model | MGI Sequence Detail 5538 C57BL/6J ±  kb
transcript OTTMUST00000117899 VEGA | MGI Sequence Detail 4724 Not Applicable 
polypeptide OTTMUSP00000065857 VEGA | MGI Sequence Detail 386 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002147 5-Hydroxytryptamine 1B receptor
InterPro IPR002231 5-Hydroxytryptamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001162 5-hydroxytryptamine receptor 1B
References
(Earliest) J:43 Maroteaux L, et al., Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3020-4
(Latest) J:197633 Cai X, et al., Local potentiation of excitatory synapses by serotonin and its alteration in rodent models of depression. Nat Neurosci. 2013 Apr;16(4):464-72
All references(120)
Other
accession IDs
MGD-MRK-11000

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory