Htr1b
Gene Detail

Symbol Name ID

Htr1b 5-hydroxytryptamine (serotonin) receptor 1B MGI:96274

Synonyms

5-HT<1B> receptor, 5-HT1B receptor, 5HT1B receptor

Feature Type

protein coding gene

Genetic Map

Chromosome 9

44.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr9:81631392-81632552 bp, - strand From NCBI annotation of GRCm38   1161 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:669  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 5-hydroxytryptamine receptor 1
Gene Tree: Htr1b

Human homologs

Human Homolog		HTR1B, 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
NCBI Gene ID		3351
neXtProt AC		NX_P28222
Human Synonyms		5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12
Human Chr (Location)		6q13; chr6:78171948-78173120 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit an increase in body weight, aggression, drinking behavior, and osteoblast proliferation and bone mass, and show altered spatial learning and operant conditional behavior as well as reduced anxiety-related response and startle reflex, and small testes.

 

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	behavior, bone remodeling, ...
Component	cytoplasm, integral to membrane, ...
Function	drug binding, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (71)    Tissues (65)    Images (9)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	25
RT-PCR	46

cDNA source data(3)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(6) Genomic(1) cDNA(3) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000049511 (Evidence)
Entrez Gene	15551 (Evidence)
UniGene	445308
DFCI	TC1735752
DoTS	DT.91316076
NIA Mouse Gene Index	U069366
Consensus CDS Project	CCDS23370.1
International Mouse Knockout Project Status	Htr1b

Sequences

Length	Strain/Species
genomic	15551	NCBI Gene Model | MGI Sequence Detail	1161	C57BL/6J
transcript	NM_010482	RefSeq | MGI Sequence Detail	1161	Not Specified
polypeptide	P28334	UniProt | EBI | MGI Sequence Detail	386	Not Applicable

All sequences(15) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(6 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002147	5-Hydroxytryptamine 1B receptor
InterPro	IPR002231	5-Hydroxytryptamine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001162	5-hydroxytryptamine receptor 1B

Graphical View of Protein Domain Structure

References

(Earliest) J:43 Maroteaux L, et al., Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3020-4
(Latest) J:191669 Kode A, et al., FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin. J Clin Invest. 2012 Oct 1;122(10):3490-503
All references(118)

Other accession IDs

MGD-MRK-11000