Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HTR1A
  • Mouse genes Htr1a
  • Rat genes Htr1a
  • Zfish genes htr1aa,htr1ab
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Htr1a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	HTR1A	IMP		Human	PMID:22957663
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	HTR1A	IDA		Human	PMID:8393041
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr1a	IMP		Mouse	MGI:MGI:1314969|PMID:9826725
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr1a	IDA		Mouse	PMID:8254366
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr1a	IMP		Rat	PMID:12149253|RGD:730812
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	Htr1a	IDA		Rat	PMID:8271204|RGD:2303617
Molecular Function	GO:0001965	G-protein alpha-subunit binding	Htr1a	IPI	RGD:2713|RGD:2714|RGD:628732|RGD:2717	Rat	PMID:16772521|RGD:2303642
Molecular Function	GO:0005515	protein binding	HTR1A	IPI	UniProtKB:P11362	Human	PMID:22035699
Molecular Function	GO:0005515	protein binding	HTR1A	IPI	UniProtKB:P32121	Human	PMID:24157794
Molecular Function	GO:0005515	protein binding	HTR1A	IPI	UniProtKB:P11362	Human	PMID:25485703
Molecular Function	GO:0005515	protein binding	HTR1A	IPI	UniProtKB:O43194	Human	PMID:26365466
Molecular Function	GO:0005515	protein binding	Htr1a	IPI	UniProtKB:Q6PEC3	Rat	PMID:18685031|RGD:21201278
Molecular Function	GO:0005515	protein binding	Htr1a	IPI	RGD:620713	Rat	PMID:22035699|RGD:8553774
Molecular Function	GO:0005515	protein binding	Htr1a	IPI	UniProtKB:Q04589	Rat	PMID:22035699|RGD:8553774
Molecular Function	GO:0005515	protein binding	Htr1a	IPI	UniProtKB:Q04589	Rat	PMID:25485703|RGD:11568029
Molecular Function	GO:0090722	receptor-receptor interaction	HTR1A	IDA		Human	PMID:24157794
Molecular Function	GO:0051378	serotonin binding	Htr1a	IDA		Rat	PMID:8271204|RGD:2303617
Molecular Function	GO:0005102	signaling receptor binding	Htr1a	IPI	RGD:620713	Rat	PMID:25485703|RGD:11568029
Cellular Component	GO:0043203	axon hillock	Htr1a	IDA		Rat	PMID:18622042|RGD:2303638
Cellular Component	GO:0098982	GABA-ergic synapse	Htr1a	EXP		Rat	PMID:10381597|RGD:13702211
Cellular Component	GO:0098982	GABA-ergic synapse	Htr1a	IDA		Rat	PMID:10381597|RGD:13702211
Cellular Component	GO:0043025	neuronal cell body	Htr1a	IDA		Rat	PMID:18622042|RGD:2303638
Cellular Component	GO:0005886	plasma membrane	HTR1A	IDA		Human	PMID:22957663
Cellular Component	GO:0042734	presynaptic membrane	Htr1a	EXP		Rat	PMID:10381597|RGD:13702211
Cellular Component	GO:0042734	presynaptic membrane	Htr1a	IDA		Rat	PMID:10381597|RGD:13702211
Biological Process	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	HTR1A	IDA		Human	PMID:8393041
Biological Process	GO:0007198	adenylate cyclase-inhibiting serotonin receptor signaling pathway	Htr1a	IMP		Rat	PMID:8271204|RGD:2303617
Biological Process	GO:0001662	behavioral fear response	Htr1a	IMP		Mouse	MGI:MGI:1314969|PMID:9826725
Biological Process	GO:0035640	exploration behavior	Htr1a	IMP		Mouse	MGI:MGI:1314969|PMID:9826725
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	HTR1A	IMP		Human	PMID:22957663
Biological Process	GO:0098664	G protein-coupled serotonin receptor signaling pathway	Htr1a	IDA		Mouse	MGI:MGI:64131|PMID:8254366
Biological Process	GO:0007214	gamma-aminobutyric acid signaling pathway	Htr1a	IMP	MGI:MGI:2387408	Mouse	PMID:16925594
Biological Process	GO:0014053	negative regulation of gamma-aminobutyric acid secretion	Htr1a	IMP		Rat	PMID:30217553|RGD:15023474
Biological Process	GO:0097114	NMDA glutamate receptor clustering	Htr1a	IDA		Rat	PMID:18442977|RGD:7241017
Biological Process	GO:0031117	positive regulation of microtubule depolymerization	Htr1a	IDA		Rat	PMID:18442977|RGD:7241017
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Htr1a	EXP		Rat	PMID:10381597|RGD:13702211
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Htr1a	IDA		Rat	PMID:10381597|RGD:13702211
Biological Process	GO:0042053	regulation of dopamine metabolic process	Htr1a	IMP		Mouse	MGI:MGI:1927024|PMID:11080193
Biological Process	GO:0060259	regulation of feeding behavior	Htr1a	IDA		Rat	PMID:11900812|RGD:2303608
Biological Process	GO:0014062	regulation of serotonin secretion	Htr1a	IMP		Mouse	MGI:MGI:1314969|PMID:9826725
Biological Process	GO:0042428	serotonin metabolic process	Htr1a	IMP		Mouse	MGI:MGI:1927024|PMID:11080193
Biological Process	GO:0007210	serotonin receptor signaling pathway	Htr1a	IMP		Mouse	MGI:MGI:1314969|PMID:9826725
Biological Process	GO:0007210	serotonin receptor signaling pathway	Htr1a	IMP		Rat	PMID:11927181|RGD:2303632
Biological Process	GO:0007210	serotonin receptor signaling pathway	Htr1a	IMP		Rat	PMID:12149253|RGD:730812
Biological Process	GO:0021522	spinal cord motor neuron differentiation	htr1ab	IMP	ZFIN:ZDB-MRPHLNO-160210-1	Zfish	PMID:26565906

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern