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Htr1a
Gene Detail
Symbol

Name
ID
Htr1a
5-hydroxytryptamine (serotonin) receptor 1A
MGI:96273
Synonyms
5-HT1A receptor, Gpcr18
Feature Type
protein coding gene
Genetic Map
Chromosome 13
56.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr13:105443693-105448133 bp, + strand
From NCBI annotation of GRCm38

  4441 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20148  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HTR1A
Protein SuperFamily: 5-hydroxytryptamine receptor 1
Gene Tree: Htr1a

Human
homologs
HTR1A, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3350
neXtProt AC: NX_P08908

Human Synonyms: 5HT1a, 5-HT1A, 5-HT-1A, ADRB2RL1, ADRBRL1, G-21, PFMCD

Human Chr (Location): 5q11.2-q13; chr5:63960048-63962292 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HTR1A

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations show a common phenotype, including augmented anxious-like behavior in the elevated plus-maze, open-field, and novel object tests, reduced immobility in the forced-swim or tail-suspension test, and changes in density of 5-HTT binding in several brain regions.
 
Human Diseases Modeled in Mice Using Htr1a (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Htr1a interacts with 241 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process adenylate cyclase-inhibiting serotonin receptor signaling pathway, behavior, ...
Component axon hillock, integral component of membrane, ...
Function drug binding, G-protein alpha-subunit binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (84)    Tissues (65)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 38
RT-PCR 46
cDNA source data(11)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN htr1aa, htr1ab    NEW 
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(13) Primer pair(1) Other(3)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000021721 (Evidence)
Entrez Gene 15550 (Evidence)
UniGene 4716
DFCI TC1583949, TC1643348, TC1651744, TC1743412
DoTS DT.110955528, DT.55166832
NIA Mouse Gene Index U015221
Consensus CDS Project CCDS26756.1
International Mouse Phenotyping Consortium Status Htr1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15550 NCBI Gene Model | MGI Sequence Detail 4441 C57BL/6J ±  kb
transcript NM_008308 RefSeq | MGI Sequence Detail 4441 C57BL/6 
polypeptide Q64264 UniProt | EBI | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(6) : SNPs within 2kb(20 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000610 5-Hydroxytryptamine 1A receptor
InterPro IPR002231 5-Hydroxytryptamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001161 5-hydroxytryptamine receptor 1A
Graphical View of Protein Domain Structure
References
(Earliest) J:10019 Sundaresan S, et al., Genes for HMG-CoA reductase and serotonin 1a receptor are on mouse chromosome 13. Somat Cell Mol Genet. 1989 Sep;15(5):465-9
(Latest) J:220591 Kim JY, et al., Postnatal maintenance of the 5-Ht1a-Pet1 autoregulatory loop by serotonin in the raphe nuclei of the brainstem. Mol Brain. 2014;7:48
All references(124)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-10999, MGD-MRK-16345, MGI:99565

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory