Htr1a
Gene Detail

Symbol Name ID

Htr1a 5-hydroxytryptamine (serotonin) receptor 1A MGI:96273

Synonyms

5-HT1A receptor, Gpcr18

Feature Type

protein coding gene

Genetic Map

Chromosome 13

56.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr13:105443693-105448133 bp, + strand From NCBI annotation of GRCm38   4441 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20148  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 5-hydroxytryptamine receptor 1
Gene Tree: Htr1a

Human homologs

Human Homolog		HTR1A, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
NCBI Gene ID		3350
neXtProt AC		NX_P08908
Human Synonyms		5HT1a, 5-HT1A, 5-HT-1A, ADRB2RL1, ADRBRL1, G-21, PFMCD
Human Chr (Location)		5q11.2-q13; chr5:63255875-63258119 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HTR1A

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygotes for targeted null mutations show a common phenotype, including augmented anxious-like behavior in the elevated plus-maze, open-field, and novel object tests, reduced immobility in the forced-swim or tail-suspension test, and changes in density of 5-HTT binding in several brain regions.

 
Human Diseases Modeled Using Mouse Htr1a (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	adenylate cyclase-inhibiting serotonin receptor signaling pathway, behavior, ...
Component	axon hillock, integral to membrane, ...
Function	drug binding, G-protein alpha-subunit binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (84)    Tissues (65)    Images (14)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	38
RT-PCR	46

cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(2) cDNA(13) Primer pair(1) Other(3)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000021721 (Evidence)
Entrez Gene	15550 (Evidence)
UniGene	4716
DFCI	TC1583949, TC1643348, TC1651744, TC1743412
DoTS	DT.110955528, DT.55166832
NIA Mouse Gene Index	U015221
Consensus CDS Project	CCDS26756.1
International Mouse Knockout Project Status	Htr1a

Sequences

Length	Strain/Species
genomic	15550	NCBI Gene Model | MGI Sequence Detail	4441	C57BL/6J
transcript	NM_008308	RefSeq | MGI Sequence Detail	4441	C57BL/6
polypeptide	Q64264	UniProt | EBI | MGI Sequence Detail	421	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(6) : SNPs(18 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000610	5-Hydroxytryptamine 1A receptor
InterPro	IPR002231	5-Hydroxytryptamine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001161	5-hydroxytryptamine receptor 1A

Graphical View of Protein Domain Structure

References

(Earliest) J:10019 Sundaresan S, et al., Genes for HMG-CoA reductase and serotonin 1a receptor are on mouse chromosome 13. Somat Cell Mol Genet. 1989 Sep;15(5):465-9
(Latest) J:191866 Baccini G, et al., Impaired chemosensitivity of mouse dorsal raphe serotonergic neurons overexpressing serotonin 1A (Htr1a) receptors. PLoS One. 2012;7(9):e45072
All references(115)

Other accession IDs

MGD-MRK-10999, MGD-MRK-16345, MGI:99565