Htr1a Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Htr1a
5-hydroxytryptamine (serotonin) receptor 1A
MGI:96273

19 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Htr1a^tm1Rhn/Htr1a⁺ involves: 129S1/Sv	increased anxiety-related response	J:51280
Htr1a^tm1Rhn/Htr1a^tm1Rhn 129S6/SvEvTac-Htr1a^tm1Rhn	abnormal serotonin level	J:65662, J:70686
	increased dopamine level	J:65662
	increased noradrenaline level	J:65662
	normal nervous system phenotype	J:65662, J:70686
Htr1a^tm1Rhn/Htr1a^tm1Rhn involves: 129S1/Sv	behavioral despair	J:51280
Htr1a^tm1Rhn/Htr1a^tm1Rhn involves: 129S1/Sv	increased anxiety-related response	J:51280
Htr1a^tm1Rhn/Htr1a^tm1Rhn involves: 129S/SvEv * 129S1/Sv	abnormal nervous system physiology	J:167655
Htr1a^tm1Rhn/Htr1a^tm1Rhn involves: 129S/SvEv * 129S1/Sv	increased anxiety-related response	J:167655
Htr1a^tm1Tct/Htr1a⁺ involves: 129X1/SvJ * C57BL/6J	behavioral despair	J:51565
Htr1a^tm1Tct/Htr1a⁺ involves: 129X1/SvJ * C57BL/6J	increased anxiety-related response	J:51565
Htr1a^tm1Tct/Htr1a^tm1Tct involves: 129X1/SvJ * C57BL/6J	normal behavior/neurological phenotype	J:51565
	behavioral despair	J:51565
	increased anxiety-related response	J:51565
	increased thigmotaxis	J:51565
	normal nervous system phenotype	J:51565
Htr1a^tm1Toth/Htr1a⁺ involves: 129P2/OlaHsd * Black Swiss	increased anxiety-related response	J:49752
Htr1a^tm1Toth/Htr1a^tm1Toth involves: 129P2/OlaHsd * Black Swiss	abnormal spatial learning	J:66581
	decreased paired-pulse facilitation	J:61579, J:66581
	increased anxiety-related response	J:49752, J:61579
	increased locomotor activity	J:49752
	increased susceptibility to pharmacologically induced seizures	J:66581
Htr1a^tm2Rhn/Htr1a⁺ involves: BALB/c * C57BL/6	decreased vertical activity	J:118885
Htr1a^tm3.1Rhn/? Tg(HCRT-tTA)G5Ahky/0 B6.Cg-Htr1a^tm3.1Rhn Tg(HCRT-tTA)G5Ahky	abnormal sleep duration	J:212974
	abnormal sleep pattern	J:212974
	fragmentation of sleep/wake states	J:212974
	increased frequency of paradoxical sleep	J:212974
	increased slow-wave sleep duration	J:212974

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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