Tg(HCRT-tTA)G5Ahky
Transgene Detail

Summary

• Symbol: Tg(HCRT-tTA)G5Ahky
• Name: transgene insertion G5, Akihiro Yamanaka
• MGI ID: MGI:5582928
• Synonyms: Orexin-tTA
• Transgene: Tg(HCRT-tTA)G5Ahky Location: unknown
• Alliance: Tg(HCRT-tTA)G5Ahky page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The human prepro-orexin (HCRT) promoter drives the expression of 0.7 kb of the mammalianized tetracycline-controlled transcriptional activator (tTA). In situ hybridization on brain slices confirmed expression in orexin neurons. Lines 29, C5, and G5 show the highest tTA mRNA expression. (J:212974)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:212974 Tabuchi S, et al., Influence of inhibitory serotonergic inputs to orexin/hypocretin neurons on the diurnal rhythm of sleep and wakefulness. Sleep. 2013 Sep;36(9):1391-404
• All: 3 reference(s)