Htr1a^tm1Tct
Targeted Allele Detail

Summary

• Symbol: Htr1a^tm1Tct
• Name: 5-hydroxytryptamine (serotonin) receptor 1A; targeted mutation 1, Laurence H Tecott
• MGI ID: MGI:2387410
• Synonyms: 5-HT[1A] receptor-null
• Gene: Htr1a Location: Chr13:105580147-105584630 bp, + strand Genetic Position: Chr13, 56.92 cM
• Alliance: Htr1a^tm1Tct page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51565
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3' portion of the coding region was replaced with a neomycin selection cassette. Transcript was undetected in homozygous mutant mice by Northern blot analysis. Autoradiography indicated confirmed the absence of functional protein. (J:51565)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr1a Mutation: 25 strains or lines available

References

• Original: J:51565 Heisler LK, et al., Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice [see comments]. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):15049-54
• All: 7 reference(s)