Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HPN
  • Mouse genes Hpn
  • Rat genes Hpn
  • Zfish genes hpn
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hpn

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008233	peptidase activity	HPN	IDA		Human	PMID:16908524
Molecular Function	GO:0008233	peptidase activity	HPN	IDA		Human	PMID:19843851
Molecular Function	GO:0005515	protein binding	HPN	IPI	UniProtKB:Q7TDY3	Human	PMID:15614436
Molecular Function	GO:0005515	protein binding	HPN	IPI	UniProtKB:P07093	Human	PMID:19911255
Molecular Function	GO:0005515	protein binding	HPN	IPI	UniProtKB:O00526	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HPN	IPI	UniProtKB:P11686	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HPN	IPI	UniProtKB:Q12983	Human	PMID:32296183
Molecular Function	GO:0004252	serine-type endopeptidase activity	HPN	IDA		Human	PMID:16908524
Molecular Function	GO:0008236	serine-type peptidase activity	HPN	IDA		Human	PMID:19911255
Cellular Component	GO:0009986	cell surface	HPN	IDA		Human	PMID:16908524
Cellular Component	GO:0009986	cell surface	HPN	IDA		Human	PMID:8346233
Cellular Component	GO:0005911	cell-cell junction	Hpn	IMP		Mouse	MGI:MGI:3719967|PMID:17620368
Cellular Component	GO:0005789	endoplasmic reticulum membrane	HPN	IDA		Human	PMID:17918732
Cellular Component	GO:0070062	extracellular exosome	HPN	HDA		Human	PMID:23533145
Cellular Component	GO:0016020	membrane	HPN	IDA		Human	PMID:19843851
Cellular Component	GO:0043025	neuronal cell body	Hpn	IDA		Mouse	MGI:MGI:5308539|PMID:17918732
Cellular Component	GO:0031965	nuclear membrane	HPN	IDA		Human	PMID:15614436
Cellular Component	GO:0005886	plasma membrane	HPN	IDA		Human	PMID:1885621
Cellular Component	GO:0005886	plasma membrane	HPN	IDA		Human	PMID:8346233
Cellular Component	GO:0005886	plasma membrane	Hpn	IDA		Mouse	PMID:12744720
Biological Process	GO:0034769	basement membrane disassembly	HPN	IDA		Human	PMID:16908524
Biological Process	GO:0072378	blood coagulation, fibrin clot formation	hpn	IMP	ZFIN:ZDB-MRPHLNO-160411-7	Zfish	PMID:23954211
Biological Process	GO:0042632	cholesterol homeostasis	Hpn	IMP	MGI:MGI:3575149	Mouse	PMID:22912808
Biological Process	GO:0090103	cochlea morphogenesis	Hpn	IMP		Mouse	MGI:MGI:5306554|PMID:20683358
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	Hpn	IMP		Mouse	MGI:MGI:5306554|PMID:20683358
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	Hpn	IMP		Mouse	MGI:MGI:5308539|PMID:17918732
Biological Process	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	Hpn	IMP		Mouse	MGI:MGI:3719967|PMID:17620368
Biological Process	GO:0060429	epithelium development	Hpn	IEP		Mouse	MGI:MGI:5306336|PMID:8346233
Biological Process	GO:0010693	negative regulation of alkaline phosphatase activity	Hpn	IMP	MGI:MGI:3575149	Mouse	PMID:22912808
Biological Process	GO:0043066	negative regulation of apoptotic process	HPN	IDA		Human	PMID:15614436
Biological Process	GO:0050680	negative regulation of epithelial cell proliferation	HPN	IDA		Human	PMID:19843851
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	HPN	IDA		Human	PMID:19843851
Biological Process	GO:0097195	pilomotor reflex	Hpn	IMP		Mouse	MGI:MGI:3719967|PMID:17620368
Biological Process	GO:0043923	positive regulation by host of viral transcription	HPN	IDA		Human	PMID:15614436
Biological Process	GO:0030307	positive regulation of cell growth	HPN	IMP		Human	PMID:8346233
Biological Process	GO:0010628	positive regulation of gene expression	Hpn	IMP		Mouse	MGI:MGI:3719967|PMID:17620368
Biological Process	GO:2000347	positive regulation of hepatocyte proliferation	HPN	IDA		Human	PMID:15614436
Biological Process	GO:0010756	positive regulation of plasminogen activation	HPN	IDA		Human	PMID:16908524
Biological Process	GO:2000611	positive regulation of thyroid hormone generation	Hpn	IMP		Mouse	MGI:MGI:3719967|PMID:17620368
Biological Process	GO:0071805	potassium ion transmembrane transport	Hpn	IMP		Mouse	MGI:MGI:3719967|PMID:17620368
Biological Process	GO:0006508	proteolysis	HPN	IDA		Human	PMID:16908524
Biological Process	GO:0006508	proteolysis	HPN	IDA		Human	PMID:19843851
Biological Process	GO:0006508	proteolysis	HPN	IDA		Human	PMID:19911255
Biological Process	GO:0006508	proteolysis	HPN	IDA		Human	PMID:24227843
Biological Process	GO:0008360	regulation of cell shape	HPN	IMP		Human	PMID:8346233
Biological Process	GO:1900003	regulation of serine-type endopeptidase activity	hpn	IMP	ZFIN:ZDB-MRPHLNO-160411-7	Zfish	PMID:23954211
Biological Process	GO:0097066	response to thyroid hormone	Hpn	IMP		Mouse	MGI:MGI:5306554|PMID:20683358
Biological Process	GO:0007605	sensory perception of sound	Hpn	IMP	MGI:MGI:3575149	Mouse	PMID:22912808

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern