| GO term: | negative regulation of alkaline phosphatase activity |
| GO id: | GO:0010693 |
| Definition: | Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. |
| Number of paths to term: | 45 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processbiological regulationregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of catalytic activitynegative regulation of catalytic activitynegative regulation of hydrolase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of catalytic activityregulation of hydrolase activitynegative regulation of hydrolase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of catalytic activityregulation of hydrolase activityregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of catalytic activityregulation of hydrolase activityregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processbiological regulationregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processbiological regulationregulation of molecular functionnegative regulation of molecular functionnegative regulation of catalytic activitynegative regulation of hydrolase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processbiological regulationregulation of molecular functionregulation of catalytic activitynegative regulation of catalytic activitynegative regulation of hydrolase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processbiological regulationregulation of molecular functionregulation of catalytic activityregulation of hydrolase activitynegative regulation of hydrolase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processbiological regulationregulation of molecular functionregulation of catalytic activityregulation of hydrolase activityregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processbiological regulationregulation of molecular functionregulation of catalytic activityregulation of hydrolase activityregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processcellular processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processdephosphorylationregulation of dephosphorylationregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processcellular processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processdephosphorylationregulation of dephosphorylationregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processcellular processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processcellular processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processcellular processcellular metabolic processphosphorus metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processcellular processcellular metabolic processphosphorus metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processcellular processcellular metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processcellular processcellular metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processcellular processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processcellular processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processmetabolic processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processdephosphorylationregulation of dephosphorylationregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processmetabolic processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processdephosphorylationregulation of dephosphorylationregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processmetabolic processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processmetabolic processcellular metabolic processphosphorus metabolic processphosphate-containing compound metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processmetabolic processcellular metabolic processphosphorus metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processmetabolic processcellular metabolic processphosphorus metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processmetabolic processcellular metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processmetabolic processcellular metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processmetabolic processregulation of metabolic processregulation of catalytic activitynegative regulation of catalytic activitynegative regulation of hydrolase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processmetabolic processregulation of metabolic processregulation of catalytic activityregulation of hydrolase activitynegative regulation of hydrolase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processmetabolic processregulation of metabolic processregulation of catalytic activityregulation of hydrolase activityregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processmetabolic processregulation of metabolic processregulation of catalytic activityregulation of hydrolase activityregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processmetabolic processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processmetabolic processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processregulation of biological processregulation of cellular processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processregulation of biological processregulation of metabolic processregulation of catalytic activitynegative regulation of catalytic activitynegative regulation of hydrolase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processregulation of biological processregulation of metabolic processregulation of catalytic activityregulation of hydrolase activitynegative regulation of hydrolase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processregulation of biological processregulation of metabolic processregulation of catalytic activityregulation of hydrolase activityregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processregulation of biological processregulation of metabolic processregulation of catalytic activityregulation of hydrolase activityregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activitybiological_processregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activitynegative regulation of phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activitynegative regulation of phosphoprotein phosphatase activity +biological_processregulation of biological processregulation of metabolic processregulation of cellular metabolic processregulation of phosphorus metabolic processregulation of phosphate metabolic processregulation of dephosphorylationregulation of phosphatase activityregulation of alkaline phosphatase activitynegative regulation of alkaline phosphatase activity [GO:0010693] (3 genes, 4 annotations)positive regulation of alkaline phosphatase activityMouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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