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Hpn
Gene Detail
 Symbol
Name
ID
Hpn
hepsin
MGI:1196620
Synonyms Hlb320
Feature Type protein coding gene
Genetic Map
Chromosome 7
19.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:31098725-31115290 bp, - strand
From VEGA annotation of GRCm38

  16566 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20498  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: serine protease hepsin
Gene Tree: Hpn

Human
homologs
Human Homolog HPN, hepsin
NCBI Gene ID 3249
neXtProt AC  NX_P05981
Human Synonyms  TMPRSS1
Human Chr (Location)  19q13.12; chr19:35040506-35066577 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation are hypothyroidic and develop profound hearing loss associated with structural changes in the tectorial membrane and a myelination defect affecting the compaction of spiral ganglion neurons.
 
Interactions
Hpn interacts with 50 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process basement membrane disassembly, cholesterol homeostasis, ...
Component cell-cell junction, cell surface, ...
Function calcium-activated potassium channel activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (131)    Tissues (45)    Images (34)
Theiler Stages: 2, 11, 13, 14, 22, 23, 28
Assay TypeResults
RNA in situ 109
Northern blot 9
RT-PCR 13
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(83) cDNA(76) Primer pair(6) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000036085 (Evidence)
Ensembl Gene ModelENSMUSG00000001249 (Evidence)
Entrez Gene15451 (Evidence)
UniGene19182
DFCITC1579570, TC1750590
DoTSDT.101214528, DT.101706215, DT.492621, DT.94367722
NIA Mouse Gene IndexU028413
EC3.4.21.106
Consensus CDS ProjectCCDS52187.1, CCDS52188.1, CCDS71936.1
International Mouse Knockout Project StatusHpn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036085 VEGA Gene Model | MGI Sequence Detail 16566 C57BL/6J ±  kb
transcript OTTMUST00000092716 VEGA | MGI Sequence Detail 1743 Not Applicable 
polypeptide OTTMUSP00000051305 VEGA | MGI Sequence Detail 445 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(8) UniProt(7)
Polymorphisms SNPs within 2kb(266 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015352 Hepsin, SRCR
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR017448 Speract/scavenger receptor-related
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000008733 serine protease hepsin
References (Earliest) J:180502 Torres-Rosado A, et al., Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7181-5
(Latest) J:187708 Aljakna A, et al., Pla2g12b and Hpn Are Genes Identified by Mouse ENU Mutagenesis That Affect HDL Cholesterol. PLoS One. 2012;7(8):e43139
All references(47)
Other
accession IDs
MGI:2141811, MGI:2142029, MGI:3575147

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory