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Hpn Gene Detail
Summary
  • Symbol
    Hpn
  • Name
    hepsin
  • Synonyms
    Hlb320
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196620
    NCBI Gene: 15451
  • Gene Overview
    MyGene.info: HPN
Location & Maps
more
  • Sequence Map
    Chr7:31098725-31115290 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16566 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 19.30 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    HPN, hepsin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HPN, hepsin
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TMPRSS1
  • Links
    NCBI Gene ID: 3249
    neXtProt AC: NX_P05981

  • Chr Location
    19q13.12; chr19:35040506-35066577 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (ENU)
    1
  • Targeted
    3
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for a null mutation are hypothyroidic and develop profound hearing loss associated with structural changes in the tectorial membrane and a myelination defect affecting the compaction of spiral ganglion neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036085 VEGA Gene Model | MGI Sequence Detail 16566 C57BL/6J ±  kb
transcript OTTMUST00000092716 VEGA | MGI Sequence Detail 1743 Not Applicable  
polypeptide OTTMUSP00000051305 VEGA | MGI Sequence Detail 445 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    264 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 85
    cDNA 77
    Primer pair 7
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2141811, MGI:2142029, MGI:3575147
References
more
  • Summaries
    All 41
    Developmental Gene Expression 12
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:180502 Torres-Rosado A, et al., Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7181-5
  • Latest
    J:187708 Aljakna A, et al., Pla2g12b and Hpn Are Genes Identified by Mouse ENU Mutagenesis That Affect HDL Cholesterol. PLoS One. 2012;7(8):e43139

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory