Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes HOXD4
  • Mouse genes Hoxd4
  • Rat genes Hoxd4
  • Zfish genes hoxd4a
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Hoxd4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	HOXD4	IDA		Human	PMID:1756725
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	HOXD4	IMP		Human	PMID:1756725
Molecular Function	GO:0005515	protein binding	HOXD4	IPI	UniProtKB:Q9BYU1	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	HOXD4	IPI	UniProtKB:Q9NW38	Human	PMID:32296183
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	HOXD4	IMP		Human	PMID:1756725
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	HOXD4	IDA		Human	PMID:28473536
Cellular Component	GO:0030054	cell junction	HOXD4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	HOXD4	IDA		Human	GO_REF:0000052
Biological Process	GO:0001525	angiogenesis	hoxd4a	IMP	ZFIN:ZDB-MRPHLNO-130509-3	Zfish	PMID:23554940
Biological Process	GO:0001525	angiogenesis	hoxd4a	IMP	ZFIN:ZDB-MRPHLNO-130509-4	Zfish	PMID:23554940
Biological Process	GO:0009952	anterior/posterior pattern specification	Hoxd4	IGI	MGI:MGI:96176	Mouse	PMID:7628700
Biological Process	GO:0009952	anterior/posterior pattern specification	Hoxd4	IMP	MGI:MGI:2151488	Mouse	PMID:7750651
Biological Process	GO:0060216	definitive hemopoiesis	hoxd4a	IMP	ZFIN:ZDB-MRPHLNO-130509-4	Zfish	PMID:23554940
Biological Process	GO:0060216	definitive hemopoiesis	hoxd4a	IMP	ZFIN:ZDB-MRPHLNO-130509-3	Zfish	PMID:23554940
Biological Process	GO:0048568	embryonic organ development	HOXD4	IEP		Human	PMID:2879245
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Hoxd4	IMP	MGI:MGI:2151488	Mouse	PMID:7750651
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	Hoxd4	IGI	MGI:MGI:96176	Mouse	PMID:7628700
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	HOXD4	IDA		Human	PMID:1756725
Biological Process	GO:0060215	primitive hemopoiesis	hoxd4a	IMP	ZFIN:ZDB-MRPHLNO-130509-3	Zfish	PMID:23554940
Biological Process	GO:0060215	primitive hemopoiesis	hoxd4a	IMP	ZFIN:ZDB-MRPHLNO-130509-4	Zfish	PMID:23554940
Biological Process	GO:0048863	stem cell differentiation	Hoxd4	IDA		Mouse	PMID:19796622
Biological Process	GO:0001570	vasculogenesis	hoxd4a	IMP	ZFIN:ZDB-MRPHLNO-130509-4	Zfish	PMID:23554940
Biological Process	GO:0001570	vasculogenesis	hoxd4a	IMP	ZFIN:ZDB-MRPHLNO-130509-3	Zfish	PMID:23554940

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern